Usefulness of PRP Therapy in Androgenic Alopecia

Asian Journal of Transfusion Science, 2015

Background: Platelet-rich plasma (PRP) has shown remarkable beneficial effects without any major adverse reactions in the treatment of androgenic alopecia. The growth factors in activated autologous PRP induce the proliferation of dermal papilla cells. Objectives: The objective was to investigate the clinical efficacy of PRP in treatment of androgenic alopecia. Materials and Methods: Ten patients were given autologous PRP injections on the affected area of alopecia over a period of 3 months at interval of 2-3 weeks and results were assessed. Results: Three months after the treatment, the patients presented clinical improvement in the hair counts, hair thickness, hair root strength, and overall alopecia. Conclusion: PRP appears to be a cheap, effective, and promising therapy for androgenic alopecia with no major adverse effects.

Dermatologic Surgery, 2019

BACKGROUND Platelet-rich plasma (PRP) treatment may encourage hair growth by promoting cellular maturation, differentiation, and proliferation. OBJECTIVE The objective of this study was to evaluate the effectiveness of PRP as a treatment for androgenetic alopecia (AGA). MATERIALS AND METHODS A literature search combined with meta-analysis was used to calculate the overall standardized mean difference (SMD) in hair density in patients treated with PRP injections in comparison with baseline and placebo treatment. Chi squared analysis and Fisher exact test were used to investigate variation in protocols. RESULTS The overall SMD in hair density was 0.58 (95% confidence interval [CI]: 0.35-0.80) and 0.51 (95% CI: 0.23-0.80, p < .0004) in favor of PRP treatment when compared with baseline and placebo treatment, respectively. CONCLUSION Platelet-rich plasma is beneficial in the treatment of AGA. It is recommended that 3 monthly sessions of PRP (once monthly •3 treatments) be used followed by a 3-to 6-month maintenance period.

Aesthetic plastic surgery, 2017

Androgenetic alopecia (AGA), the most common cause of hair loss in both sexes, accounts for 95% of all cases of hair loss. Although the literature has suggested that both nonactivated (n-PRP) and activated autologous (a-PRP) PRP can be used to treat AGA, we did not find any study investigating the use of homologous PRP (h-PRP) for this purpose. Also, to the best of our knowledge, there are no studies comparing the efficacy of h-PRP, a-PRP, or n-PRP on AGA therapy. The aim of this study was to compare the increase in hair density, average number of platelets, complications, preparation, and duration of application in the treatment of AGA using a-PRP, n-PRP, and h-PRP. Between 2014 and 2015, we studied male patients who had experienced increased hair loss in the last year. Patients were divided into three groups: Group 1 received n-PRP, Group 2 received active PRP, and Group 3 received h-PRP. For Group 1, PRP was prepared by a single centrifugation prepared from the patient&#39;s own ...

Skin Appendage Disorders, 2017

Androgenetic alopecia (AGA) is a hair loss disorder affecting 80% of men and 50% of women throughout their lifetime. Therapies for AGA are limited and there is no cure. There is a high demand for hair restoration. Platelet-rich plasma (PRP), a treatment modality shown to promote wound healing, has also been explored as a treatment for AGA. This literature review was conducted to assess the effectiveness of PRP treatment for AGA. Twelve studies conducted from 2011 to 2017 were evaluated and summarized by study characteristics, mode of preparation, and treatment protocols. A total of 295 subjects were given PRP or control treatment in these studies, and evaluated for terminal hair density, hair quality, anagen/telogen hair ratio, keratinocyte proliferation, blood vessel density, etc. Some studies also provided subject self-assessment reports. Most of the studies reviewed showed effectiveness of PRP in increasing terminal hair density/diameter. Additional investigations are needed to d...

Zagazig University Medical Journal

Background: Androgenetic alopecia (AGA) is an androgen-dependent, hereditary dermatological disorder , affecting men and women causing progressive thinning of the scalp hair in a defined Characteristic pattern, with significant negative impact on social and psychological state of patients. Aim of the work: To evaluate the efficacy and safety of Platelet Rich Plasma injection in androgenetic alopecia patients. Subjects and methods: A therapeutic trial study was carried out on a sample size of 20 patients with AGA who attended the outpatients' clinics of dermatology department-Zagazig University Hospitals. Results: At baseline, 16 patients (80%) had a positive pull test with a mean number of 9 hairs. At 4 th and 8 th week ,The hair loss decreased with a mean number of 5.5 and 3 hairs respectively. After PRP injection 2 patients (10%) achieved high improvement , 6 patients (30%) achieved moderate improvement , 6 patients (30%) achieved mild improvement and 6 patients (30%) achieved no change, with final patient's satisfaction (40%). Conclusion: PRP injection is relatively effective in treatment of Androgenetic alopecia.

Journal of cutaneous and aesthetic surgery, 2014

Platelet-rich plasma (PRP) has become a newer method for the treatment of various types of alopecia. In this prospective study, safety, efficacy and feasibility of PRP injections in treating androgenic alopecia were assessed. Eleven patients suffering from hair loss due to androgenic alopecia and not responding to 6 months treatment with minoxidil and finasteride were included in this study. The hair pull test was performed before every treatment session. A total volume of 2-3 cc PRP was injected in the scalp by using an insulin syringe. The treatment was repeated every two weeks, for a total of four times. The outcome was assessed after 3 months by clinical examination, macroscopic photos, hair pull test and patient&#39;s overall satisfaction. A significant reduction in hair loss was observed between first and fourth injection. Hair count increased from average number of 71 hair follicular units to 93 hair follicular units. Therefore, average mean gain is 22.09 follicular units per...

Journal of Clinical Medicine, 2022

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IOSR Journals , 2019

Background: Androgenetic alopecia (AGA) is a common disorder, with possible psychosocial implications. It affects around 80% of men and 50% of women throughout their lifetime. Platelet-rich plasma (PRP) treatment has gained popularity among different surgical specialities for improving various conditions. Aim: In this prospective study efficacy of PRP in treating androgenetic alopecia is assessed Methods: A total of 28 cases of clinically diagnosed male and female patients with androgenetic alopecia in the age group of 18-45 years constituted the present study. Detailed history and clinical examination of cases was done. All the routine investigations were carried out. PRP injections were given to alopecia areas once in every four weeks for 5 times. Results: A total of 28 patients were studied. Large number belonged to the age group 21-30 years. Majority were from class 2 to 5, Hamilton Norwood classification of AGA. The family history was positive in 12.22patients showedimprovement of varying degrees ranging from single class to 2 classes, self-assessment questionnaire and global photographs of 78.5% patients showed improvement. Conclusion: In a developing country like India, autologous PRP treatment is an affordable alternative therapy for androgenetic alopecia.As the demand for less invasive, highly effective cosmetic procedures is growing, PRP in androgenetic alopecia is found to be simple, safe and effective procedure.There is a high level of patient satisfaction with PRP treatment, minimal side effects and the treatment is cost effective to the patient.

Journal of Pakistan Association of Dermatology, 2020

Background Androgenetic alopecia (AGA) is a common hair loss disorder affecting both men and women. Despite multiple therapeutic options, treatment of AGA remains unsatisfactory. Platelet-rich plasma (PRP) is an autologous concentrate of plasma with a greater count of platelets than that of whole blood and is effective in promoting hair regrowth. Objective This randomized controlled clinical trial was conducted to evaluate the efficacy and safety of PRP therapy in male androgenetic alopecia (AGA). Materials and Methods This study was conducted at the Department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University from October, 2016 to October, 2017. Fifty four male patients with AGA diagnosed by dermatologist were enrolled by consecutive sampling. The participants were divided into two groups by odd (group- A) and even numbering (Group-B). Group-A patients were treated with PRP injections on their scalp at 4 weeks interval for 3 sessions and group-B patients wer...

Academia Mental Health and Well-Being, 2024

Objectives: This study examines attitudes consisting of thoughts, feelings, and behaviours (T-F-B) chains experienced in imagination by physicians before and during seeking treatment as a patient, and before and during treating another physician as a patient. Methods: Ninety-six physicians, from three countries, completed a questionnaire about their imagined attitudes in four situations: "before and during your visit to a physician as a patient" and "before and during a visit to you, as a physician, by another physician in the capacity of a patient". These questionnaires were retrolectively qualitatively analysed. Results: All four situations evoked negative and/or stressful reaction chains of T-F-B. Some of these chains were related to the situation in which two physicians meet, such as shame in asking for medical care from another physician and fear of failing as a consulting physician. Conclusion: There are specific barriers to physicians seeking treatment from and providing treatment to other physicians, especially shame on both sides. Aspiring physicians can learn what it means to ask for medical treatment as a physician, it can make them less anxious or insecure, and they can develop more compassion for their patients. The physician-to-physician healthcare barriers - a phenomenological qualitative study