AIM To report an another case of duodenal GIST in patient that was treated with Whipple procedure. MATERIAL OF STUDY We report a case of 69 years old men that was admitted with melena. The preoperative investigations suggested a suspected duodenal GIST.A Whipple pancreatico-duodenectomy was performed. Only 3-5% of GISTs occur in the duodenum. DISCUSSION GIST were described as a separate entity by Mazur and Clark in 1983. These tumors are the most common among mesenchymal tumors of the gastrointeninal tract. The clinical presentations of duodenal GIST are highly variable. There is no consensus on the optimal surgical treatment of duodenal GIST.The aim was to achieve a R0-type surgery with complete en bloc surgical resection of the tumor and the surrounding tissue CONCLUSION: In conclusion the duodenal GIST are fairly rare. The clinical symptomatology is very variable even if frequently occur with digestive bleeding. the purpose of the surgery is the complete removal of the tumor (R0) however looking to perform minimum resections. KEY WORDS GI bleeding, GIST, Pancreaticoduodenectomy.
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