Papers by M. Thirumoorthi
Seminars in Perinatology, 1985
American Journal of Perinatology, 1999
Herpes simplex type 2 (HSV2) disease developed sequentially among two parents and their newborn. ... more Herpes simplex type 2 (HSV2) disease developed sequentially among two parents and their newborn. The father first became ill with upper-respiratory symptoms and fever. Then, 5 days later, shortly after delivery, the mother had fever, pharyngitis, and diarrhea. Subsequently, the infant developed undifferentiated febrile illness at the age of 3 days. HSV etiology was recognized by incidental isolation of HSV2 from the newborn naospharynx. The father never developed genital lesions and the mother's symptoms remained nonspecific for several days prior to the onset of genital manifestations. The sequential emergence and manifestations of these infections could have been misconstrued for an intrafamily spread of respiratory or enteric viruses. This cluster illustrates that HSV2 may cause sequential symptomatic disease in susceptible individuals mimicking other viruses.
Scandinavian Journal of Infectious Diseases, 1994
All consecutive patients with positive blood culture for Candida species over a 6-year period wer... more All consecutive patients with positive blood culture for Candida species over a 6-year period were evaluated to define recent epidemiologic characteristics of candidemia, and to assess the prevalence of late complications. We encountered 106 cases; medical records were available for 99 of them. The rate of candidemia was increasing until 1990, after which it declined. C. albicans was the most common species, but in the last 2 years, C. tropicalis and C. parapsilosis were emerging. Overall mortality rate was 54.5% without significant variation during the study period. Antifungal therapy was withheld in 24/99 cases (24.2%). Decision to withhold treatment was taken in 19/59 cases (32.2%) before the availability of fluconazole in 1990, compared with 5/40 cases (12.5%) afterward (p < 0.05). Follow-up was possible in 35 instances for an average period of 17.1 months (range: 1-48 months); 7 of these individuals, all with transient candidemia, were untreated. None of the survivors developed late complications. These findings demonstrate that candidemia appears to be declining since 1990, with a noticeable decrease in the prevalence of C. albicans but an increase in that of C. tropicalis and C. parapsilosis, that fewer patients are left untreated since fluconazole became available, and that the risk of late complications among the survivors is low.
American Journal of Diseases of Children, 1978
Yersinia enterocolitica systemic infections are uncommon and osteomyelitis due to this organism i... more Yersinia enterocolitica systemic infections are uncommon and osteomyelitis due to this organism is very rare. We report a 9-year-old girl with thalassemia major, liver cirrhosis, and hemosiderosis who developed osteomyelitis of the rib caused by Y enterocolitica type 0:3. Serologic response to the infection was confirmed. No definite source of infection was identified.
Clinical Infectious Diseases, 2004
The American journal of gastroenterology, 1989
A 15-yr-old, Arabic male presented with painful, recurrent, self-resolving oral and genital ulcer... more A 15-yr-old, Arabic male presented with painful, recurrent, self-resolving oral and genital ulcers, erythema nodosum and uveitis. Behcet's disease was diagnosed. A few months later, he experienced anorexia, abdominal pain, diarrhea, and weight loss. Although all routine laboratory and radiologic investigations were negative, colonoscopy revealed the presence of serpiginous ulcers with pseudopolyps and inflamed intervening mucosa in the proximal half of the colon. Therapy with oral steroids was helpful, but the disease exacerbated a few months after prednisone was discontinued. Repeat evaluation showed similar endoscopic findings and, on colonic biopsy, noncaseating granulomas compatible with Crohn's disease were seen. Again, the patient responded well to oral steroids and sulfasalazine. We believe that gastrointestinal involvement in our patient is compatible with Crohn's disease and that screening tests to rule out chronic inflammatory bowel disease should be performed ...
Journal of Pediatric Orthopaedics
Sixty-nine children with acute hematogenous osteomyelitis were studied retrospectively. All were ... more Sixty-nine children with acute hematogenous osteomyelitis were studied retrospectively. All were treated with antibiotics, and eight underwent fenestration osteotomies. In the operatively treated group, three poor results occurred. In a more recent prospective study of 44 patients, drainage was undertaken only when pus was aspirated. All results were good or excellent. We recommend operative drainage only when a demonstrated abscess is found by aspiration.
... RIAD KHATIB", MUTHAYIPALAYAM C. THIRUMOORTHIb, BRIAN KELLY&a... more ... RIAD KHATIB", MUTHAYIPALAYAM C. THIRUMOORTHIb, BRIAN KELLY' and KEVIN J. GRADY" From the Departments of Obstetrics and Gynecologyc, Medicine" and ... 2. Schlossberg D, Delgado J, Moore MM, Wishner A, Mohn J. An epidemic of avian and human psittacosis. ...
The Indian Journal of Pediatrics
Clinical Infectious Diseases
The Indian Journal of Pediatrics, 1995
Seminars in perinatology, 1985
Journal of clinical microbiology, 1976
Over an 18-month period, cultures from 95 infants and children yielded 146 anaerobic organisms in... more Over an 18-month period, cultures from 95 infants and children yielded 146 anaerobic organisms in 110 clinical specimens. Bacteroides was the most frequently isolated anaerobe, followed by Propionibacterium and Clostridium species. Intra-abdominal sources, soft tissues, and blood were the three major sources (82%) of isolation of anaerobes. Whereas most patients (58%) were over 5 years of age and only 11% were newborns, anaerobic infections constituted a rather uniform proportion of all infections, regardless of sources, in all age groups. Anaerobes accounted for only 2.9% of all positive cultures encountered from the various sources. Rates of recovery of anaerobes from intra-abdominal sources were significantly the highest, and from soft-tissue infections they were significantly the lowest. The anaerobic bacteremias observed were of no clinical significance when Propionibacterium species were isolated; however, recovery of other anaerobes from the blood, and primarily Bacteroides s...
Pediatrics, 1978
Two patients with periobital cellulitis, one of whom also had buccal cellulitis, had violaceous d... more Two patients with periobital cellulitis, one of whom also had buccal cellulitis, had violaceous discoloration of the skin. Blood cultures from both patients yielded Streptococcus pneumoniae. Therefore, pneumococci should be considered, in addition to Haemophilus influenzae, as possible causes of cellulitis with violaceous or bluish-red discoloration.
Pediatrics, 1979
Colonization of prepubertal boys and girls with group B streptococci was studied prosepctively fo... more Colonization of prepubertal boys and girls with group B streptococci was studied prosepctively for one year. Throat, anal canal, and vaginal cultures were obtained from 415 children not receiving antimicrobics. The over-all colonization rate at any site was 11.3% and did not vary with age, sex, or season. Streptococci were recovered most commonly from the anal canal. Throat colonization was comparable in boys and girls. A total of 71 sites were positive for the organism in the 47 colonized children. Serotype Ia was the most common (41% of isolates). Types II and III accounted for 24% and 20%, respectively. Colonization at more than one site occurred in 20 children and in two of these children, different serotypes were recovered from different sites.
Pediatric infectious disease
Fifty-seven children, ages 1 month to 17 years, were treated with parenteral ceforanide. Most pat... more Fifty-seven children, ages 1 month to 17 years, were treated with parenteral ceforanide. Most patients received 20 mg/kg of the drug intramuscularly every 12 hours. The mean duration of ceforanide therapy was 6.3 days (range, 3 to 14 days). Because ceforanide has a relatively long half-life of 1.94 +/- 0.43 hours (range, 1.1 to 3.3 hours), suprainhibitory plasma concentrations against most pathogens recovered from the study patients were maintained for 8 to 12 hours after a dose. Ceforanide diffused well into abscess cavities and joint fluid. Initial clinical response was satisfactory in all patients; however, one patient with Haemophilus influenzae type b bacteremia had relapse of bacteremia one week after ceforanide therapy. Ceforanide was well-tolerated with minimal pain at the site of intramuscular injections. Other side effects were minor and transient.
Developmental pharmacology and therapeutics, 1981
37 patients ranging in age from 9 months to 14 years, with various infections, were treated with ... more 37 patients ranging in age from 9 months to 14 years, with various infections, were treated with moxalactam. The pharmacokinetics of the drug were studied in 18 patients. The mean plasma concentration 1 h after a 25 mg/kg intravenous dose was 41.4 micrograms/ml +/- 15.6 SD, the half-life was 1.5 h +/- 0.4 SD and the mean Vd was 550 ml/kg +/- 239 SD. The total body clearance of moxalactam was 4.1 ml/min/kg +/- 1.5 SD and the mean renal clearance 4.5 ml/min/kg +/- 2.8 SD. Between 52 and 107% of the administered dose was recovered in the urine within 8 h after administration. The pharmacokinetics after the first and multiple doses of moxalactam were similar, indicating no accumulation of the drug with repeated administration. The clinical response was adequate in 35 of 37 patients. Moxalactam was well tolerated and only minor and transient hematological abnormalities were observed.
Scandinavian Journal of Infectious Diseases, 1995
... RIAD KHATIB", MUTHAYIPALAYAM C. THIRUMOORTHIb, BRIAN KELLY&a... more ... RIAD KHATIB", MUTHAYIPALAYAM C. THIRUMOORTHIb, BRIAN KELLY' and KEVIN J. GRADY" From the Departments of Obstetrics and Gynecologyc, Medicine" and ... 2. Schlossberg D, Delgado J, Moore MM, Wishner A, Mohn J. An epidemic of avian and human psittacosis. ...
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Papers by M. Thirumoorthi