Manish Kumar

Vellore Institute of Technology, School of Biosciences and Technology, Alumnus

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M.Sc. (Botany), M.Tech. (Biotechnology), Research Scholar
Department of Biotechnology, School of Bio Sciences & Technology
Vellore Institute of Technology, Vellore, Tamil Nadu, India
Supervisors: Prof. C. Shanthi, Department of Biotechnology, School of Bio Sciences & Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India and Dr. Sumita Danda, Professor & Head, Department of Clinical Genetics, Christian Medical College, Vellore, Tamil Nadu, India
Phone: +91-8084878291, +91-7530000658
Address: Manish Kumar
ME - 010- 0017, Dhruvneeti Nagar
Near Samarpan Hospital, Rajneeti Road
At- Madhopur, Post Office - Basudeopur
Munger - 811202, Bihar, India

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Comparative expression analysis of embryonic development-related genes at different stages of parthenogenetic andin vitrofertilized embryos in caprine

Zygote, 2013

SummaryAberrant gene expression occurs in parthenogenetic embryos due to abnormal epigenetic modi... more SummaryAberrant gene expression occurs in parthenogenetic embryos due to abnormal epigenetic modifications in the genome that probably diminish viability and enhance developmental abnormalities in these embryos. In the present study, five developmentally important genes (HPRT1,Cx43,Sox2,MestandIGF2R) were analysed at different stages in parthenotes (haploid and diploid) and compared with similar stages inin vitrofertilized (IVF) embryos. The results indicated that in haploid parthenotes expression ofHPRT1was upregulated (P< 0.05) only at the 2–4-cell stage whereasCx43expression was significantly (P< 0.05) downregulated in all stages as compared with the control. However, expression of this gene was upregulated (P< 0.05) in 2–4-cell and morula stages of diploid parthenotes. Expression ofSox2was significantly (P< 0.05) downregulated in morula stage haploid parthenotes, whereas it was upregulated (P< 0.05) in 8–16-cell stage diploid embryos. The expression ofMestwas upre...

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Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics

arXiv, 2023

Cancer is a complex and multifaceted disease having a number of composite problems to be consider... more Cancer is a complex and multifaceted disease having a number of composite problems to be considered including cancer immune evasion, therapy resistance, and recurrence for prevention and cure. Fundamentally it remains a genetic disease as diverse aspects of the complexity of tumor growth and cancer development relate to its genetic machinery and requires addressing the problems at the level of genome and epigenome. Presumably, the mutational changes occurring in the regulatory genes responsible for maintaining optimal cell growth, proliferation, and differentiation gradually lead to cancer progression and metastasis. Importantly, patients with the same cancer types respond differently to cancer therapies, indicating the need for a patient-specific treatment option for cancer cure. Precision oncology is the field of cancer research that focuses on the genetic profiling of individual tumors to identify targetable alterations involved in cancer development for custom-tailored personalized treatment of the disease. It is to rely upon the genomic study of cancer cells to get a clear picture of the prognosis and pathways involved in disease progression and to look for the means to selectively target them to ensure effective treatment of this deadly disease. Thus, precision oncology combines cancer diagnosis and prognosis followed by designing a treatment regimen for precise treatment of cancer at different stages and times. This article aims to briefly explain the foundations and frontiers of precision oncology in the context of technological advances being made in this direction to assess its scope and importance in the realization of a proper cure for cancer.

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Precision Oncology bringing a paradigm shift in the treatment of cancer

Academia Letters, 2021

The genetic changes appearing in the information system of the cells that program its unregulated... more The genetic changes appearing in the information system of the cells that program its unregulated growth and proliferation gradually lead to cancer manifestation and the treatment options must be guided accordingly. The critical roles played by some of the molecules associated with the specific signaling pathways and cell microenvironment that lead to oncogenesis and metastasis have been described precisely in recent years based on findings of the human genome project. Precision oncology relying on the genomic study of the cancer cells to better understand the prognosis and pathways involved with disease progression for the cure is destined to serve the purpose adequately. This article tries to comprehensively elucidate the foundations and frontiers of precision oncology in the context of single-cell technology for efficient cancer treatment.

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Comparative expression analysis of embryonic development-related genes at different stages of parthenogenetic andin vitrofertilized embryos in caprine

Zygote, 2013

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Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics

arXiv, 2023

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Precision Oncology bringing a paradigm shift in the treatment of cancer

Academia Letters, 2021

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