Papers by Valentine NDIKUM
Asian journal of research in medical and pharmaceutical sciences, Apr 19, 2019
Aim: Azadirachta indica A. Juss commonly called 'Indian Lilac' or 'Margosa' is used in the South ... more Aim: Azadirachta indica A. Juss commonly called 'Indian Lilac' or 'Margosa' is used in the South West region of Cameroon to treat malaria, typhoid, intestinal worms and diabetes, and as mosquito repellent. Diabetes, a major risk factor for the development of cardiovascular diseases, is
BMC Infectious Diseases
Background Many studies have reported high efficacy and safety of artesunate-amodiaquine (AS-AQ) ... more Background Many studies have reported high efficacy and safety of artesunate-amodiaquine (AS-AQ) and artemether-lumefantrine (AL) when administered under direct observation in Cameroon. There is paucity of data to support their continuous use in home-based treatment of uncomplicated Plasmodium falciparum malaria in Cameroon. Hence, this study aimed to assess the effectiveness and safety of AS-AQ versus AL for home-based treatment of uncomplicated P. falciparum malaria among children 6–120 months in Yaoundé, Cameroon. Methods A two-arm, open-label, randomized, controlled trial comparing the equivalence of AS-AQ (experimental group) and AL (control group) was carried out from May 2019 to April 2020 at two secondary hospitals in Yaoundé. Participants were randomized to receive either AS-AQ or AL. After the first dose, antimalarial drugs were given at home, rather than under direct observation by a study staff. The conventional on-treatment and post-treatment laboratory and clinical eva...
confidence interval (CI) on the difference in PCR-corrected cure rates of ASAQ and DHAP when comp... more confidence interval (CI) on the difference in PCR-corrected cure rates of ASAQ and DHAP when compared to AL was accepted if the lower limit of the CI was greater than −10%. Secondary outcomes were parasite and fever clearances
Microbiology Research International, 2018
HEALTH SCIENCES AND DISEASES, 2018
Background. In-hospital mortality in elderly patients reaches 32% in some departments of Internal... more Background. In-hospital mortality in elderly patients reaches 32% in some departments of Internal Medicine in Yaounde and the causes are largely unknown. The study aimed at identifying some factors associated with this high mortality in our environment. Methods. The study was carried out from June to August 2017, in the Internal Medicine departments of the Yaounde Teaching Hospital and the Yaounde Central Hospital. We included all patients aged of 60 and over hospitalized in the Internal Medicine departments during the study period and looked for iatrogeneic events in the rcords. Iatrogenic events were defined as any adverse clinical and / or biological manifestations occurring during hospitalization and which cannot be explained by the current disease. The data were analyzed using the SPSS 23.0 software. The Chi-square and the exact Fischer test were used to study associations between variables with a significance threshold of less than 0.05. We obtained the approval of the Instit...
Asian Journal of Research in Medical and Pharmaceutical Sciences, 2020
Introduction: The World Health Organization (WHO) has estimated that about 80% of the world’s pop... more Introduction: The World Health Organization (WHO) has estimated that about 80% of the world’s population rely mostly on traditional medicine. Peptic ulcer disease (PUD) which results from an imbalance between stomach acid-pepsin and mucosal defense barriers is a chronic disease affecting up to 10% of the world’s population and represents 33% of gastroenterology consultations in Cameroon. The people in low medium incomecountries depend mostly on medicinal plants for primary healthcare since they can be accessed quickly and are affordable. Such plant is Ficus thonningii Blume, which is found abundantly in Africa and also in Cameroon. The objective of this study was to phytochemically screened the aqueous fruits extract of Ficus thonningii (AEFFt), and investigate their antiulcer activity. Methods: The aqueous fruits extract was phytochemically screened following standard qualitative methods. Four in vitro tests to characterize antacid properties were carried out. Ulcers were induced u...
Malaria Research and Treatment, 2018
Background. As a result of the spread of parasites resistant to antimalarial drugs, Malaria treat... more Background. As a result of the spread of parasites resistant to antimalarial drugs, Malaria treatment guidelines in Cameroon evolved from nonartemisinin monotherapy to artemisinin-based combination therapy. The aim of this study was to assess the effect of these therapy changes on the prevalence of molecular markers of resistance from 2003 to 2013 in Mutengene, Cameroon. Methodology. Dry blood samples (collected in 2003–2005 and 2009–2013) were used for parasite DNA extraction. Drug resistance genes were amplified by PCR and hybridized with oligonucleotide probes or subjected to restriction digestion. The prevalence of individual marker polymorphisms and haplotypes was compared in these two study periods using the Chi square test. Results. Alleles conferring resistance to 4-aminoquinolines in the Pfcrt 76T and Pfmdr1 86Y, 184F, and 1246Y genotypes showed a significant reduction of 97.0% to 66.9%, 83.6% to 45.2%, 97.3% to 56.0%, and 3.1% to 0.0%, respectively (P<0.05). No differen...
Malaria journal, Jan 31, 2015
Severe malaria is a medical emergency with high mortality in children below 5 years of age especi... more Severe malaria is a medical emergency with high mortality in children below 5 years of age especially in sub-Saharan Africa. Recently, quinine has been replaced by artesunate as the first-line drug in the treatment of severe malaria in Cameroon. No local data are yet available on the efficacy of artesunate with respect to the different quinine regimens used in this setting. This study was undertaken at the Ebolowa Regional Hospital (ERH), which is located in a region of perennial transmission of malaria. This was a randomized, open-label trial in children aged 3 months to 15 years, admitted in the hospital with severe malaria due to Plasmodium falciparum confirmed on microscopy after informed parental consent. Patients were randomized into four groups. Group 1 (ARTES) received parenteral artesunate at 2.4 mg/kg at H0, H12, H24 and then once daily; Group 2 (QLD) received a loading dose of quinine base at 16.6 mg/kg followed 8 hours later by an eight-hourly maintenance dose of 8.3 mg/...
Topics in Public Health, 2015
Health Management - Different Approaches and Solutions, 2011
Annals of Tropical Medicine And Parasitology, 2001
Topics in Public Health, 2015
Malaria Research and Treatment
Background. As a result of the spread of parasites resistant to antimalarial drugs, Malaria treat... more Background. As a result of the spread of parasites resistant to antimalarial drugs, Malaria treatment guidelines in Cameroon evolved from nonartemisinin monotherapy to artemisinin-based combination therapy. The aim of this study was to assess the effect of these therapy changes on the prevalence of molecular markers of resistance from 2003 to 2013 in Mutengene, Cameroon.Methodology. Dry blood samples (collected in 2003–2005 and 2009–2013) were used for parasite DNA extraction. Drug resistance genes were amplified by PCR and hybridized with oligonucleotide probes or subjected to restriction digestion. The prevalence of individual marker polymorphisms and haplotypes was compared in these two study periods using the Chi square test.Results. Alleles conferring resistance to 4-aminoquinolines in thePfcrt76T andPfmdr186Y, 184F, and 1246Y genotypes showed a significant reduction of 97.0% to 66.9%, 83.6% to 45.2%, 97.3% to 56.0%, and 3.1% to 0.0%, respectively (P<0.05). No difference was...
There has been an enormous increase in the clinical use of generic drugs. However, this has not b... more There has been an enormous increase in the clinical use of generic drugs. However, this has not been accompanied by frequent and systematic evaluations of their therapeutic efficacy compared with branded products. Although essential to reduce health budget costs and to promote pharmaceutical competition, generic drugs remain a topic of intense controversy. Generics are usually intended to be interchangeable with branded products; however, there have been allegations that some have a lower therapeutic equivalence than their branded counterparts The main objective of this study was to compare the in vitro potency of generic and branded antibiotics on E. coli and S. aureus. A sample of generic and corresponding branded Ciprofloxacin, Ceftriazone, Gentamicin and Doxycycline were used to prepare antibiotic disk for Kirby-Bauer disk diffusion susceptibility antimicrobial assay on E. coli ATCC 25922 and S. aureus ATCC 25923. The inhibition zones were measured and relative potencies were ca...
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Papers by Valentine NDIKUM