Papers by William A. Cunningham
Neuropsychologia, 2003
Recent brain imaging and lesion studies provide converging evidence for amygdala involvement in j... more Recent brain imaging and lesion studies provide converging evidence for amygdala involvement in judgments of fear and trust based on facial expression [Adolphs et al.
Personality & social psychology bulletin, 2004
Two studies investigated relationships among individual differences in implicit and explicit prej... more Two studies investigated relationships among individual differences in implicit and explicit prejudice, right-wing ideology, and rigidity in thinking. The first study examined these relationships focusing on White Americans' prejudice toward Black Americans. The second study provided the first test of implicit ethnocentrism and its relationship to explicit ethnocentrism by studying the relationship between attitudes toward five social groups. Factor analyses found support for both implicit and explicit ethnocentrism. In both studies, mean explicit attitudes toward outgroups were positive, whereas implicit attitudes were negative, suggesting that implicit and explicit prejudices are distinct; however, in both studies, implicit and explicit attitudes were related (r = .37, .47). Latent variable modeling indicates a simple structure within this ethnocentric system, with variables organized in order of specificity. These results lead to the conclusion that (a) implicit ethnocentrism exists and (b) it is related to and distinct from explicit ethnocentrism.
Psychological science, 2004
NeuroImage, 2005
We used dense-array event-related potentials (ERP) to examine the time course and neural bases of... more We used dense-array event-related potentials (ERP) to examine the time course and neural bases of evaluative processing. Participants made good vs. bad (evaluative) and abstract vs. concrete (nonevaluative) judgments of socially relevant concepts (e.g., ''murder,'' ''welfare''), and then rated all concepts for goodness and badness. Results revealed a late positive potential (LPP) beginning at about 475 ms post-stimulus and maximal over anterior sites. The LPP was lateralized (higher amplitude and shorter latency) on the right for concepts later rated bad, and on the left for concepts later rated good. Moreover, the degree of lateralization for the amplitude but not the latency was larger when participants were making evaluative judgments than when they were making nonevaluative judgments. These data are consistent with a model in which discrete regions of prefrontal cortex (PFC) are specialized for the evaluative processing of positive and negative stimuli. D
Cognitive, affective & behavioral neuroscience, 2005
proposed two self-regulatory or motivational systems-one sensitive to gains (promotion) and one s... more proposed two self-regulatory or motivational systems-one sensitive to gains (promotion) and one sensitive to losses (prevention). To examine the interaction of motivation and cognition, participants made good/bad or abstract/concrete judgments about concepts during fMRI scanning. After scanning, participants rated the extent to which each stimulus was good and bad and completed a questionnaire that measured promotion/prevention orientation. For each participant, contrast maps were generated representing the association between neural processing and stimulus valence (good/bad), and these factors were then regressed against participants' promotion and prevention focus scores. For the good/bad but not for the abstract/concrete task, promotion focus was associated with greater activity in the amygdala, anterior cingulate, and extrastriate cortex for positive stimuli, and prevention focus was associated with activity in the same regions for negative stimuli; these results are consistent with the hypothesis that the way in which evaluative information is processed is influenced by individual differences in self-regulatory focus.
Cognitive, affective & behavioral neuroscience, 2005
Using fMRI, we investigated the functional organization of prefrontal cortex (PFC) as participant... more Using fMRI, we investigated the functional organization of prefrontal cortex (PFC) as participants briefly thought of a single just-experienced item (i.e., refreshed an active representation). The results of six studies, and a meta-analysis including previous studies, identified regions in left dorsolateral, anterior, and ventrolateral PFC associated in varying degrees with refreshing different types of information (visual and auditory words, drawings, patterns, people, places, or locations). In addition, activity increased in anterior cingulate with selection demands and in orbitofrontal cortex when a nonselected item was emotionally salient, consistent with a role for these areas in cognitive control (e.g., overcoming "mental rubbernecking"). We also found evidence that presenting emotional information disrupted an anterior component of the refresh circuit. We suggest that refreshing accounts for some neural activity observed in more complex tasks, such as working memory, long-term memory, and problem solving, and that its disruption (e.g., from aging or emotion) could have a broad impact.
Trends in cognitive sciences, 2007
Psychological science, 2008
Social neuroscience, 2007
We investigated self-regulatory focus as one source of variation in encoding of, and memory for, ... more We investigated self-regulatory focus as one source of variation in encoding of, and memory for, emotional words. Participants wrote about their hopes and aspirations (promotion focus) or dut ies and obligations (prevention focus). In a subsequent incidental encoding task during functional magnetic resonance imaging (fMRI), participants evaluated emotional (positive and negative) and neutral words as either good or bad. A surprise memory test followed, outside the scanner. We observed a dissociation in posterior cingulate cortex (PCC), where activity during the evaluation task was greater when words were focusconsistent (positive for the promotion focus group, negative for the prevention focus group).
NeuroImage, 2008
In order to investigate the systems underlying the automatic and controlled processes that suppor... more In order to investigate the systems underlying the automatic and controlled processes that support social attitudes, we conducted an fMRI study that combined an implicit measure of race attitudes with the Quadruple Process model (Quad model). A number of previous neural investigations have adopted the Implicit Association Test (IAT) to examine the automatic processes that contribute to social attitudes. Application of the Quad model builds on this previous research by permitting measures of distinct automatic and controlled processes that contribute to performance on the IAT. The present research found that prejudiced attitudes of ingroup favoritism were associated with amygdala, medial and right lateral orbitofrontal cortex. In contrast, prejudiced attitudes of outgroup negativity were associated with caudate and left lateral orbitofrontal cortex. Frontal regions found in previous neural research on the IAT, such as anterior cingulate, dorsolateral prefrontal cortex and operculum were associated with detecting appropriate responses in situations in which they conflict with automatic associations. Insula activity was associated with attitudes towards ingroup and outgroup members, as well as detecting appropriate behavior.
Journal of cognitive neuroscience, 2009
The weak axiom of revealed preferences suggests that the value of an object can be understood thr... more The weak axiom of revealed preferences suggests that the value of an object can be understood through the simple examination of choices. Although this axiom has driven economic theory, the assumption of equation between value and choice is often violated. fMRI was used to decouple the processes associated with evaluating stimuli from evaluating one's actions. Whereas activity in left posterior areas of the orbitofrontal cortex (OFC) was associated with processing the objective value of stimuli, activity in medial anterior areas of the OFC was associated with accepting high value gambles and rejecting low value gambles; that is, making correct decisions. These data demonstrate that distinct areas of the OFC provide dissociated representations for use in adaptive decision-making and suggest an important processing distinction between the concepts of good/bad and right/wrong.
Psychological science, 2008
Classic minimal-group studies found that people arbitrarily assigned to a novel group quickly dis... more Classic minimal-group studies found that people arbitrarily assigned to a novel group quickly display a range of perceptual, affective, and behavioral in-group biases. We randomly assigned participants to a mixed-race team and used functional magnetic resonance imaging to identify brain regions involved in processing novel in-group and out-group members independently of preexisting attitudes, stereotypes, or familiarity. Whereas previous research on intergroup perception found amygdala activity-typically interpreted as negativity-in response to stigmatized social groups, we found greater activity in the amygdala, fusiform gyri, orbitofrontal cortex, and dorsal striatum when participants viewed novel in-group faces than when they viewed novel out-group faces. Moreover, activity in orbitofrontal cortex mediated the in-group bias in self-reported liking for the faces. These in-group biases in neural activity were not moderated by race or by whether participants explicitly attended to team membership or race, a finding suggesting that they occur relatively automatically. This study helps clarify the role of neural substrates involved in perceptual and affective in-group biases.
Personality & social psychology bulletin, 2009
Social neuroscience, 2009
Effective self-regulation requires the ability to consider alternate goal states in order to adap... more Effective self-regulation requires the ability to consider alternate goal states in order to adapt to shifting circumstances. Previous research on goal reflection has identified goal-type dissociations in brain regions broadly associated with self-projection. Importantly, however, there is a need to distinguish activation differences due to recruitment of distinct processes from activations that reflect common processes with varying levels of recruitment. The fact that different types of goals tend to covary naturally with time allowed us to vary the difficulty of goal reflection across content domains. Participants in an fMRI study thought about promotion or prevention goals at three time points. Goals that varied in terms of content, time-frame, valence, and abstractness but were difficult to construct (relative to other goals) activated an area of dorsal medial PFC, suggesting that this region may support general-purpose projective processes. In contrast, goals that were easy to construct activated a region of dorsolateral PFC involved in domaingeneral memory retrieval. Importantly, we also observed domain-specific effects of goal type and temporal distance; promotion goals were associated with heightened activity in medial PFC, short-term goals activated precuneus and anterior cingulate cortex, and longer-term goals activated frontal areas, including ventrolateral PFC and orbitofrontal cortex.
Social cognitive and affective neuroscience, 2009
Statistical thresholding (i.e. P-values) in fMRI research has become increasingly conservative ov... more Statistical thresholding (i.e. P-values) in fMRI research has become increasingly conservative over the past decade in an attempt to diminish Type I errors (i.e. false alarms) to a level traditionally allowed in behavioral science research. In this article, we examine the unintended negative consequences of this single-minded devotion to Type I errors: increased Type II errors (i.e. missing true effects), a bias toward studying large rather than small effects, a bias toward observing sensory and motor processes rather than complex cognitive and affective processes and deficient meta-analyses. Power analyses indicate that the reductions in acceptable P-values over time are producing dramatic increases in the Type II error rate. Moreover, the push for a mapwide false discovery rate (FDR) of 0.05 is based on the assumption that this is the FDR in most behavioral research; however, this is an inaccurate assessment of the conventions in actual behavioral research. We report simulations demonstrating that combined intensity and cluster size thresholds such as P < 0.005 with a 10 voxel extent produce a desirable balance between Types I and II error rates. This joint threshold produces high but acceptable Type II error rates and produces a FDR that is comparable to the effective FDR in typical behavioral science articles (while a 20 voxel extent threshold produces an actual FDR of 0.05 with relatively common imaging parameters). We recommend a greater focus on replication and meta-analysis rather than emphasizing single studies as the unit of analysis for establishing scientific truth. From this perspective, Type I errors are self-erasing because they will not replicate, thus allowing for more lenient thresholding to avoid Type II errors.
Social cognitive and affective neuroscience, 2011
Prior research has shown that the orbitofrontal cortex (OFC) plays an important role in the repre... more Prior research has shown that the orbitofrontal cortex (OFC) plays an important role in the representation of the evaluation of stimuli, regardless of stimulus modality. Based on these findings, researchers have proposed that the OFC serves a common currency function, allowing for the direct comparison of different types of perceptual stimuli (e.g. food, drink, money). The present study was designed to extend this research and investigate whether these same regions of OFC that have been identified in previous research are involved in evaluating imagined stimuli. Specifically, we asked participants to draw on prior attitudinal knowledge to generate internal representations of liked and disliked exemplars from different categories during functional magnetic resonance imaging. The results of this study support the idea that imagined stimuli (regardless of stimulus category) are evaluated in the OFC using a common system that has been identified in previous research for externally perceived stimuli. 1 Studies of reward and positive hedonic states typically find activation that encompasses both the subgenual cingulate [Brodmann's area (BA) 25] and an area of posterior middle orbitofrontal cortex (BA 11). For simplicity, we use the term medial OFC in this article to refer to both regions.
Neuropsychologia, 2010
Recent research and theory has highlighted the dynamic nature of amygdala activation. Rather than... more Recent research and theory has highlighted the dynamic nature of amygdala activation. Rather than simply being sensitive to a few limited stimulus categories, amygdala activation appears to be dependent on the goals of the perceiver. In this study, we extend this line of work by demonstrating that the means by which a person seeks to accomplish a goal also modulates the amygdala response. Specifically, we examine the modulatory effects of the aspects of neuroticism (volatility/withdrawal), a personality variable that has been linked to both generalized anxiety and differences in amygdala sensitivity. Whereas Neuroticism-Volatility is proposed to be associated with the fight-flight-freeze system (FFFS) and a sensitivity for any cues of negativity, Neuroticism-Withdrawal is proposed to be associated with the behavioral inhibition system (BIS) and a generalized tendency toward passive avoidance. During fMRI scanning, participants were presented with positive, negative, and neutral images and were required to approach (move perceptually closer) or avoid (move perceptually farther away) stimuli in different blocks of trials. Consistent with hypotheses proposing a dissociation between these two aspects of neuroticism, participants higher in Neuroticism-Volatility had increased amygdala activation to negative stimuli (regardless of whether they were approached or avoided), whereas participants higher in Neuroticism-Withdrawal had increased amygdala activation to all approached stimuli (regardless of stimulus valence). These data provide further support for the motivational salience hypothesis of amygdala function, and demonstrate that both the ends and means of goal pursuit are important for shaping a response.
Neuropsychologia, 2011
Recent research and theory has highlighted the dynamic nature of amygdala activation. Rather than... more Recent research and theory has highlighted the dynamic nature of amygdala activation. Rather than simply being sensitive to a few limited stimulus categories, amygdala activation appears to be dependent on the goals of the perceiver. In this study, we extend this line of work by demonstrating that the means by which a person seeks to accomplish a goal also modulates the amygdala response. Specifically, we examine the modulatory effects of the aspects of neuroticism (volatility/withdrawal), a personality variable that has been linked to both generalized anxiety and differences in amygdala sensitivity. Whereas Neuroticism-Volatility is proposed to be associated with the fight-flight-freeze system (FFFS) and a sensitivity for any cues of negativity, Neuroticism-Withdrawal is proposed to be associated with the behavioral inhibition system (BIS) and a generalized tendency toward passive avoidance. During fMRI scanning, participants were presented with positive, negative, and neutral images and were required to approach (move perceptually closer) or avoid (move perceptually farther away) stimuli in different blocks of trials. Consistent with hypotheses proposing a dissociation between these two aspects of neuroticism, participants higher in Neuroticism-Volatility had increased amygdala activation to negative stimuli (regardless of whether they were approached or avoided), whereas participants higher in Neuroticism-Withdrawal had increased amygdala activation to all approached stimuli (regardless of stimulus valence). These data provide further support for the motivational salience hypothesis of amygdala function, and demonstrate that both the ends and means of goal pursuit are important for shaping a response.
Journal of cognitive neuroscience, 2011
■ Studies have shown that fusiform face area (FFA) activity increases with visual expertise. We p... more ■ Studies have shown that fusiform face area (FFA) activity increases with visual expertise. We present an fMRI study showing that faces from a social category made relevant by an experimental manipulation (members of an experimentally created in-group) preferentially recruited the FFA even when they were matched in exposure to face stimuli from a less significant social category (members of an experimentally created out-group). Faces were randomly assigned to groups and fully counterbalanced so that no perceptual cues allowed participants to visually distinguish category membership. The results revealed a pattern of in-group enhancement (not out-group disregard), such that the FFA was selectively engaged following the presentation of in-group compared with out-group or unaffiliated control faces even when the intergroup distinction was arbitrary, and exposure to in-group and out-group faces was equivalent and brief. In addition, individual differences in FFA activity for in-group versus out-group faces were correlated with recognition memory differences for in-group and out-group faces. The effects of group membership on the FFA were not affected by task instruction to respond to in-group or out-group members and were functionally dissociated from early visual processing in the primary visual cortex. This study provides evidence that the FFA is sensitive to top-down influences and may be involved in subordinate level (vs. superordinate level) encoding of stimuli in the absence of long-term exposure or explicit task instructions. ■
Emotion (Washington, D.C.), 2012
The words we use to describe emotions can provide insight into the basic processes that contribut... more The words we use to describe emotions can provide insight into the basic processes that contribute to emotional experience. Based on a recent model of the cognitive and neural bases of affective processes, we propose that emotions arise partly from the interaction of the evaluation of one's current affective state, one's previous affective state, one's predictions for how these may change in the future, and the outcomes that one experiences following these predictions.
Uploads
Papers by William A. Cunningham