Papers by Shubhankar Mishra
Indian journal of applied research, 2016
Background:For investigation of crime it is very important to determine time since death. The tim... more Background:For investigation of crime it is very important to determine time since death. The time interval after death is very essential for the law authority, particularly when no witness is present at the scene of crime. An erroneous time of death can lead investigators in a wrong path especially in criminal cases. In fact the estimation of time since death posses a difficult problem faced by Forensic Pathologist. Materials and methods:Cases with known TSD & cause of death and Cases where clear Pericardial fluids were obtained. Result:This prospective study was undertaken with an objective to establish a linkage between levels of electrolyte and time since death. 101 diff medico legal cases with known time since death formed for cohort of the study. The pericardial fluid collected in aseptic maneuver and analyzed for time since death through Spectrophotometer to record the level of electrolyte like Potassium. The time of death was confirmed from accompany relatives, police person...
Indian journal of applied research, 2016
Apert Syndrome is a rare acrocephalosyndactylycharacterised by dysmorphic facial features, cranio... more Apert Syndrome is a rare acrocephalosyndactylycharacterised by dysmorphic facial features, craniosynostosis and severe symmetrical syndactyly of hands and feet (cutaneous and bony fusion). Inherited as a autosomal dominant trait,but most cases are sporadic. It includes prominent clinical features i.e. turricephaly,anterior open-bite maxilla, impacted and crowded teeth, cleft palate, bifid uvula,thick gingiva and mandible simulating pseudo-prognathism.Clinical, genetic and biochemical approach have recently allowed tremendous scientific advances in understanding the molecular basis of Apert Syndrome.In the present case report we report a 3 day old male child with all the clinical features in agreement with Apert Syndrome like hypertelorism, exophthalmos,Depressed nasal bridge,cleft palate,mitten hand. The pt. was referred tospecialized centre for clinical care with special needs.
IP Indian Journal of Neurosciences, 2019
Introduction: Idiopathic inflammatory demyelinating disorders of the central nervous system (IIDC... more Introduction: Idiopathic inflammatory demyelinating disorders of the central nervous system (IIDCDs) represent a broad spectrum of central nervous system (CNS) disorders thought to be of autoimmune origin. Objective of the study was to diagnose multiple sclerosis by neurological examinations, to do neuroimaging and to see the most common area of involvement.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
Introduction: Cerebral Venous Sinus Thrombosis (CVST) is a neurovascular syndrome in contrast to ... more Introduction: Cerebral Venous Sinus Thrombosis (CVST) is a neurovascular syndrome in contrast to more common arterial disease. Despite advances in the recognition of CVST in recent years, diagnosis and management can be difficult because of the diversity of underlying risk factors and the absence of a uniform treatment approach. Aim: To evaluate the syndromes associated with the CVST spectrum and its association with veins with detailed prognostication. Materials and Methods: The present hospital-based, observational study was conducted in the Department of Neurology, Sri Ramachandra Bhanja Medical College and Hospital, Cuttack, Odisha, India. A total of 52 patients of age >14 years, who presented with radiological confirmation of venous sinus thrombosis were included in the study. All their clinical and epidemiological parameters were tabulated. They were classified into four clinical syndromes namely syndrome of raised intracranial hypertension without focal deficit, syndrome o...
IJAR - Indian Journal of Applied Research, 2018
Different models of community dynamics, such as the MacArthur-Wilson theory of island biogeograph... more Different models of community dynamics, such as the MacArthur-Wilson theory of island biogeography and Hubbell's neutral theory, have given us useful insights into the workings of ecological communities. Here, we develop the niche-hypervolume concept of the community into a powerful model of community dynamics. We describe the community's size through the volume of the hypercube and the dynamics of the populations in it through the fluctuations of the axes of the niche hypercube on different timescales. While the community's size remains constant, the relative volumes of the niches within it change continuously, thus allowing the populations of different species to rise and fall in a zero-sum fashion. This dynamic hypercube model reproduces several key patterns in communities: lognormal species abundance distributions, 1/f-noise population abundance, multiscale patterns of extinction debt and logarithmic speciestime curves. It also provides a powerful framework to explore significant ideas in ecology, such as the drift of ecological communities into evolutionary time.
Indian Journal of Neonatal Medicine and Research, 2014
Aplasia cutis congenita (ACC) is a rare developmental malformation characterized by the absence o... more Aplasia cutis congenita (ACC) is a rare developmental malformation characterized by the absence of skin, extending to bone or dura in a localized or widespread area at birth. Mostly it's seen in the scalp with an autosomal dominant inheritance and slight female predisposition. Generally, it is found as a solitary lesion without other anomalies, but sometimes it is reported associated with other syndromes. The association is much appreciated in case of malformations like Patau syndrome, Wolf-Hirschhorn Syndrome, JohansonBlizzard Syndrome etc. It is not commonly seen with Edward Syndrome. Normally Edward syndrome is a rare entity and its association with ACC makes it very rare. As the survival rate of Edward syndrome is very low, these types of associations are unavailable in the literature. We present this very rare association and which was never reported before in my country.
The Journal of Obstetrics and Gynecology of India, 2022
Fraser syndrome is a rare disorder with autosomal recessive inheritance having a wide spectrum of... more Fraser syndrome is a rare disorder with autosomal recessive inheritance having a wide spectrum of phenotypic appearances. A fourteen-year-old female presented to us with a chief complaint of acute retention of urine without any cyclical abdominal pain with syndromic appearance. She had partial vaginal agenesis which was treated by successful reconstructive surgery by lotus petal flap technique followed by recanalisation. Objective of this report is to highlight the rare disease of Fraser syndrome along with successful rare surgical management.
International Journal of Biomedical and Advance Research, 2015
Castlemans disease is a rare atypical lympho-proliferative disorder characterised by enlarged hyp... more Castlemans disease is a rare atypical lympho-proliferative disorder characterised by enlarged hyperplastic lymphnodes with striking vascular proliferations. A cervical location has very rarely been reported in paediatric literature. It can be unicentric or multicentric. There are mainly four histological variants, hyaline vascular type being the commonest one.Although unicentric Castleman's disease carries a favorable prognosis in children, surgical excision is recommended to confirm the diagnosis and to rule out other causes. We report a case of unicentric cervical Castlemans disease of neck in a 6-years old male child, who came to paediatric ward with history of right sided neck mass since 2yrs. After thorough clinical examination and investigations, complete excision of the mass was done. Histopathological examination confirmed the diagnosis of Castlemans disease-hyaline vascular type. On follow-up for two years no recurrence has been seen.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2015
Niemann-Pick Disease is an autosomal recessive disorder of infancy characterized by failure to th... more Niemann-Pick Disease is an autosomal recessive disorder of infancy characterized by failure to thrive, hepatosplenomegaly and neurodegenerative changes. Inherited deficiency of acid sphingomyelinase activity leads to sphingomyelin and cholesterol storage within the lysosome. The clinical phenotype ranges from a severe infantile form with neurologic degeneration resulting in death usually by 3 years of age (type A) to a later-onset non neurologic form (type B) that is compatible with survival into adulthood. We present a case of niemann-pack disease with galaxy of typical and atypical presentation. It's a rare disease in India.
Indian Journal of Applied Research
ABSTRACT
Journal of Natural Science, Biology and Medicine, 2015
Variable atypical symptoms are commonly observed in malaria caused by Plasmodium falciparum espec... more Variable atypical symptoms are commonly observed in malaria caused by Plasmodium falciparum especially in endemic tropical nations such as India. Nystagmus is observed following involvement of the cerebellum especially during the postrecovery phase. While psychotic features such as severe agitation, hallucination, paranoia may be the early symptoms of falciparum malaria among pediatric patients, urticaria with or without fever can be the initial manifestation of the disease. As the morbidity and mortality of severe malaria are very high in India, these atypical presentations should be considered during diagnosis. We believe our report on atypical cases of falciparum malaria will sensitize doctors and health personnel about rare presentations in children and help in early diagnosis and management to reduce the severity and death toll due to the disease.
Journal of Pediatric Neurosciences, 2015
Rubinstein-Taybi syndrome (RSTS) is a rare genetic disorder with characteristic morphological ano... more Rubinstein-Taybi syndrome (RSTS) is a rare genetic disorder with characteristic morphological anomaly. Our patient was a 4.5-year-old girl came with features like broad thumbs, downward slanting palpebral fissures and mental retardation. Systemic abnormalities such as repeated infection, seizure with developmental delay were also associated with it. She was having head banging behavior abnormal slurring speech, incoordination while transferring things from one hand to other. Galaxy of clinical pictures and magnetic resonance imaging report helped to clinch the diagnosis as a case of "RSTS with corpus callosal agenesis" which to the best of our knowledge has never been reported in past from India.
Archives of Disease in Childhood - Fetal and Neonatal Edition, 2000
Presentation characteristics were reviewed in 14 children from 12 families with malignant infanti... more Presentation characteristics were reviewed in 14 children from 12 families with malignant infantile osteopetrosis seen at two large referral centres for bone marrow transplantation. Children from six of these families presented initially with symptoms of hypocalcaemia. These comprised early or late neonatal convulsions in six cases (corrected serum calcium < 1.5 mmol/l), and vomiting and irritability (serum calcium 1.68 mmol/l) in another. One other related child had severe and persistent jittering episodes almost certainly attributable to hypocalcaemia. In seven of eight cases, these symptoms developed during the first 14 days of life. Although occasionally reported previously, malignant infantile osteopetrosis remains essentially unrecognised as a cause of neonatal hypocalcaemia, often resulting in diagnostic confusion and delay. This is important in the context of curative haemopoietic stem cell transplantation where preservation of sight may depend on early intervention.
American Journal of Therapeutics, 2014
Adult-onset Still's disease (AOSD) sometimes demonstrates hematologic disorder, whereas acquired ... more Adult-onset Still's disease (AOSD) sometimes demonstrates hematologic disorder, whereas acquired amegakaryocytic thrombocytopenia (AAT) involvement is extremely rare. We herein report a 67-year-old woman with relapse of AOSD who concomitantly developed AAT. Thrombocytopenia along with high disease activity of AOSD was resistant to high-dose prednisolone, even in combination with methotrexate and tacrolimus. However, alternative treatment with cyclosporine after administering tocilizumab resulted in the improvement of thrombocytopenia, ultimately demonstrating that combination therapy based on suppressing the intractable disease activity of AOSD and subsequently adding a reliable immunosuppressant was required to achieve remission.
Scientifica, 2016
Background. In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of de... more Background. In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality.Objectives. To assess the clinical profile of the dengue infection in children less than 14 years of age and to evaluate the outcomes of dengue fever from September 2013 to August 2015 at the Pediatric Department of Maharaja Krishna Chandra Gajapati Medical College, the largest tertiary care hospital of southern Odisha.Results. A total of 97 cases were classified into 84 (86.59%) nonsevere and 13 (13.40%) severe dengue cases. The most common age of presentation was above 11 yrs. The mean age of admission was 8.7 yrs. The most common presenting symptom was fever seen in 100% and hepatomegaly (43.8%), the most common physical finding. Gastrointestinal bleeding was markedly seen in severe dengue (76.9%). Elevation in aspartate transaminase (SGOT) was found in 47.42% and thrombocytopenia in 27.5...
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Papers by Shubhankar Mishra