Nanotubes and nanowires have sparked considerable interest in biosensing applications due to thei... more Nanotubes and nanowires have sparked considerable interest in biosensing applications due to their exceptional charge transport properties and size compatibility with biomolecules. Among the various biosensing methodologies incorporating these nanostructured materials in their sensing platforms, liquid-gated field-effect transistors (LGFETs)-based device configurations outperform the conventional electrochemical measurements by their ability in providing label free, direct electronic read-out, and real-time detection. Together with integration of a microfluidic channel into the device architecture, nanotube- or nanowires-based LGFET biosensor have demonstrated promising potential toward the realization of truly field-deployable self-contained lab-on-chip devices, which aim to complement the existing lab-based methodologies. This review addresses the recent advances in microfluidic-integrated carbon nanotubes and inorganic nanowires-based LGFET biosensors inclusive of nanomaterials growth, device fabrication, sensing mechanisms, and interaction of biomolecules with nanotubes and nanowires. Design considerations, factors affecting sensing performance and sensitivity, amplification and multiplexing strategies are also detailed to provide a comprehensive understanding of present biosensors and future sensor systems development.
A facile and high performance biosensing platform using aligned carbon nanotubes on quartz substr... more A facile and high performance biosensing platform using aligned carbon nanotubes on quartz substrate is reported in this communication. Single walled carbon nanotubes are grown on quartz substrates by a chemical vapor deposition process and are characterized with field emission scanning electron microscopy and atomic force microscopy in order to verify the quality of the material. The quartz substrate is then directly used as a biosensor in a field effect transistor configuration. In order to demonstrate the sensing capabilities of the fabricated sensor devices, electronic detection of prostate specific antigen, a potential cancer biomarker, is carried out by adopting liquid gated configuration. A conductivity change due to the specific binding of target antigen with the immobilized receptor antibody demonstrates the sensing capabilities of the fabricated device. Sub-nM detection sensitivities have been obtained using the adopted direct immunoassay approach, which shows that the device responds to clinically relevant concentration regimes.
Nanotubes and nanowires have sparked considerable interest in biosensing applications due to thei... more Nanotubes and nanowires have sparked considerable interest in biosensing applications due to their exceptional charge transport properties and size compatibility with biomolecules. Among the various biosensing methodologies incorporating these nanostructured materials in their sensing platforms, liquid-gated field-effect transistors (LGFETs)-based device configurations outperform the conventional electrochemical measurements by their ability in providing label free, direct electronic read-out, and real-time detection. Together with integration of a microfluidic channel into the device architecture, nanotube- or nanowires-based LGFET biosensor have demonstrated promising potential toward the realization of truly field-deployable self-contained lab-on-chip devices, which aim to complement the existing lab-based methodologies. This review addresses the recent advances in microfluidic-integrated carbon nanotubes and inorganic nanowires-based LGFET biosensors inclusive of nanomaterials growth, device fabrication, sensing mechanisms, and interaction of biomolecules with nanotubes and nanowires. Design considerations, factors affecting sensing performance and sensitivity, amplification and multiplexing strategies are also detailed to provide a comprehensive understanding of present biosensors and future sensor systems development.
A facile and high performance biosensing platform using aligned carbon nanotubes on quartz substr... more A facile and high performance biosensing platform using aligned carbon nanotubes on quartz substrate is reported in this communication. Single walled carbon nanotubes are grown on quartz substrates by a chemical vapor deposition process and are characterized with field emission scanning electron microscopy and atomic force microscopy in order to verify the quality of the material. The quartz substrate is then directly used as a biosensor in a field effect transistor configuration. In order to demonstrate the sensing capabilities of the fabricated sensor devices, electronic detection of prostate specific antigen, a potential cancer biomarker, is carried out by adopting liquid gated configuration. A conductivity change due to the specific binding of target antigen with the immobilized receptor antibody demonstrates the sensing capabilities of the fabricated device. Sub-nM detection sensitivities have been obtained using the adopted direct immunoassay approach, which shows that the device responds to clinically relevant concentration regimes.
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Papers by Putu Mahendra