Papers by Jean paul Berrod
Ophthalmologica, 2021
Purpose: The aim of the study was to investigate the effect of tamponade duration on retinal chan... more Purpose: The aim of the study was to investigate the effect of tamponade duration on retinal changes induced by silicone oil (SO) in patients who underwent successful rhegmatogenous retinal detachment (RRD) surgery. Methods: Retrospective comparative case series of 68 patients who underwent SO tamponade for RRD. Patients were divided into 2 groups based on timing of SO removal: <6 months (group 1, n = 34) versus ≥6 months (group 2, n = 34). The main outcome measure was the change in central macular, inner, and outer retinal layer thickness (CMT, IRLT, and ORLT) before and after SO removal (SOR). Results: The median tamponade duration was 4 [Clin Ophthalmol. 2016;10:471–6, Zhonghua Yan Ke Za Zhi. 1997 Jan;33(1):39–41] months in group 1 and 8 [Arch Ophthalmol. 1994 Jun;112(6):778–85, Retina. 2004 Dec;24(6):871–7] months in group 2 (p < 0.001). The mean CMT significantly increased from 245.3 ± 22.2 μm and 238.8 ± 41.6 μm under SO to 281.3 ± 60.2 μm and 259.0 ± 43.5 μm after SOR i...
Investigative Ophthalmology & Visual Science, 2006
Acta Ophthalmologica, 2016
PurposeTo investigate aqueous flare as a preoperative predictor for later proliferative vitreoret... more PurposeTo investigate aqueous flare as a preoperative predictor for later proliferative vitreoretinopathy (PVR) development in patients with rhegmatogenous retinal detachment (RD) and to determine the validity of this measurement in patients at low clinical risk for postoperative PVR.MethodsThis study included 100 eyes of 100 patients who underwent surgery for primary RD. Aqueous flare was determined preoperatively with a laser flare‐cell meter (Kowa FM‐500, Kowa Company Ltd, Tokyo, Japan). Patients were followed for at least 6 months postoperatively. Failures related to PVR were recorded for statistical analysis.ResultsTwenty eyes (20%) developed PVR postoperatively. Preoperative flare values in these eyes were significantly higher than in eyes with no redetachment (48.12 ± 61.24 versus 17.74 ± 29.63 photon counts per millisecond (pc/ms), p = 0.002). The odds ratio for PVR development with flare values >15 pc/ms was 12.3 (p < 0.0001, 95% confidence interval, 3.54–42.59). Of 5...
Bulletin des sociétés d'ophtalmologie de France, 1988
Bulletin des sociétés d'ophtalmologie de France, 1988
Journal français d'ophtalmologie, 1988
50 corneal grafts were studied by specular microscopy. The endothelial cell morphology of the gra... more 50 corneal grafts were studied by specular microscopy. The endothelial cell morphology of the grafts was analysed by using a computerised image analysis system. The endothelial cell density decreased rapidly during the first three post-operative months (17%). It continued to decrease for the first year (52%, after which cell loss occurred at a slower rate (3% of the sample cell count per year). The coefficient of variation in cell area remained constant (27%). The percentage of endothelial cell loss might be closely associated with the reestablishment of the hexagonal cellular pattern. These results suggest that the endothelium of the graft is in a state of transition during the first year after surgery.
Bulletin des sociétés d'ophtalmologie de France
49 eyes with pseudophakic retinal detachments are operated with 44 good anatomic results (90% suc... more 49 eyes with pseudophakic retinal detachments are operated with 44 good anatomic results (90% success). These detachments are characterised by the high frequency of anterior proliferative vitreoretinopathy.
Acta Ophthalmologica, 2012
Purpose Endophthalmitis is the most feared complication of all ophthalmologic surgeries. The aim ... more Purpose Endophthalmitis is the most feared complication of all ophthalmologic surgeries. The aim of our study is to study the immune response in aqueous humor of infected patients.Methods In a prospective and multicenter study, clinical datas and aqueous humors of patients with endophthalmitis and control (cataract surgery) were collected. Multiplex immunoassay was done in order to define cytokines patterns. Two‐way ANOVA test was realized for each inflammatory marker to determine any difference between infected and control patients. Pearson linear regression was done to analyse correlation between clinical datas and cytokines levels.Results Aqueous humor was sampled in 49 patients with endophthalmitis and 88 controls. Microbial identification was obtained in 67% of cases. Endophthalmitis was leading to high levels of cytokines and chemokines of the Th1, Th17 and Treg ways. Moreover, very high levels of VEGF were noted in aqueous humors of patients with endophthalmitis as compared t...
Acta Ophthalmologica, 2012
Abstract not provided
Acta Ophthalmologica, 2020
PurposeTo develop and investigate an evidence‐based performance test for assessment of vitreoreti... more PurposeTo develop and investigate an evidence‐based performance test for assessment of vitreoretinal surgical skills on the EyeSi Surgical Simulator.MethodsTen junior residents without any surgical experience, eight senior residents with prior experience in cataract surgery and five vitreoretinal surgeons were included in the study. The test consisted of seven modules and was completed twice by all groups during a single session. Validity evidence was evaluated using Messick’s validity framework. Senior residents completed four additional test sessions and were retested 3 months after to assess skill acquisition and retention.ResultsContent was aligned with vitreoretinal surgical skills as evaluated by expert surgeons. Response process was ensured through standardized instruction and data collection. The test showed satisfactory internal consistency with Cronbach’s α = 0.76 (internal structure) and significant discriminative ability between the residents and the experienced surgeons...
Acta Ophthalmologica, 2010
ABSTRACT Purpose To evaluate the functional and anatomical outcomes of vitrectomy for epiretinal ... more ABSTRACT Purpose To evaluate the functional and anatomical outcomes of vitrectomy for epiretinal membrane (ERM) in eyes with a preoperative (acuity (VA) ≥ 0,3 LogMAR (20/40) .Methods Sixty-seven of sixty-six consecutive patients that undergone surgery for an idiopathic ERM were studied retrospectively. A combined surgery was performed on phakic eyes (n=45). The other eyes were all pseudophakic (n=22). All patients underwent ERM and internal limiting membrane removal by using 20 (n=19) or 23-gauge (n=48) vitrectomy. The main studied criteria were preoperative and postoperative best corrected visual acuity (BCVA), preoperative and postoperative central macular thickness (CMT) and integrity of junction between inner and outer segments of photoreceptors (IS/OS junction) evaluated with OCT.Results The mean preoperative VA was 0.28 logMAR (range 0.15 logMAR to 0.3 logMAR). The mean VA improved to 0.19 logMAR at a mean of 27 months following surgery (p&lt;0.0001). 71,6 % patients recovered visual acuity ≥ 0,1 logMAR (20/25). The mean preoperative CMT was 367 μm and the mean postoperative CMT was 304 μm . No correlation between postoperative BCVA and postoperative central macular thickness was noted (p=0.46). The preoperative integrity of the IS/OS line correlated with postoperative BCVA (p=0.004) but not with BCVA improvement (p=0.177).Conclusion Vitrectomy for epiretinal membrane is a safe and effective procedure that provides VA ≥ 0,1 LogMAR in 71,6% eyes with relatively good preoperative VA ( ≥ 0,3 LogMAR).Besides the baseline VA, the integrity of the IS/OS line can be used to predict excellent functional outcomes after surgery.
Acta Ophthalmologica, 2013
ABSTRACT Purpose To evaluate the anatomic and functional outcomes of epiretinal membrane peeling ... more ABSTRACT Purpose To evaluate the anatomic and functional outcomes of epiretinal membrane peeling surgery in highly myopic eyes and to compare them with non-highly myopic controls. Design: case control study in a retrospective cohort of 1776 patients undergoing surgery for epiretinal membrane alone or combined with cataract extraction. Methods Fifty-seven highly myopic eyes from 57 patients with axial length over 26 mm were included in the study. For each case studied, we selected from the same cohort one control matched for preoperative acuity, central macular thickness, and surgical technique. Best-corrected visual acuity (BCVA), decrease of central macular thickness (CMT), impact of axial length on postoperative visual recovery and postoperative complications were studied. Results The postoperative best-corrected visual acuities improved by 0,37 LogMar in highly myopic eyes versus 0,39 LogMar in controls (NS). The mean postoperative foveal thickness decrease was 110 μm in highly myopic versus 77 μm in controls (p=0,0585). We did not found any correlation between axial length and improvement of BCVA. We had no difference in the incidence of complication between the two groups. Conclusion ERM peeling gave good anatomical and functional results in highly myopic patients. The axial length has no impact on visual recovery, foveoal thickness decrease and postoperative complications.
Journal Francais D Ophtalmologie, 2008
Journal of Neuroinflammation
Background Rhegmatogenous retinal detachment (RD) involving the macula is a major cause of visual... more Background Rhegmatogenous retinal detachment (RD) involving the macula is a major cause of visual impairment despite high surgical success rate, mainly because of cone death. RD causes the infiltration of activated immune cells, but it is not clear whether and how infiltrating inflammatory cells contribute to cone cell loss. Methods Vitreous samples from patients with RD and from control patients with macular hole were analyzed to characterize the inflammatory response to RD. A mouse model of RD and retinal explants culture were then used to explore the mechanisms leading to cone death. Results Analysis of vitreous samples confirms that RD induces a marked inflammatory response with increased cytokine and chemokine expression in humans, which is closely mimicked by experimental murine RD. In this model, we corroborate that myeloid cells and T-lymphocytes contribute to cone loss, as the inhibition of their accumulation by Thrombospondin 1 (TSP1) increased cone survival. Using monocyt...
American journal of ophthalmology, 2018
To investigate the clinical benefit of internal limiting membrane (ILM) peeling as a surgical adj... more To investigate the clinical benefit of internal limiting membrane (ILM) peeling as a surgical adjunct in the repair of primary retinal detachment (RD) complicated by grade B proliferative vitreoretinopathy (PVR). Retrospective, interventional, comparative case series. Setting, study population, observationalprocedures and Main outcome measures. Institutional. Seventy-five consecutive patients who underwent vitrectomy for primary macula-off RD complicated by grade B PVR. Patients were divided into an ILM peeling (Group P) and a no ILM peeling group (Group NP). Anatomic success rate, best-corrected visual acuity, and spectral-domain optical coherence tomography (SD-OCT) characteristics were collected at 1 and 6 months. In all, 37 eyes with ILM peeling were included in Group P and 38 eyes without ILM peeling were included in Group NP. The anatomic success rate after single surgery was higher in Group P (89%) than in Group NP (66%, P = .03). Mean final visual acuity was 0.41 ± 0.40 logM...
Ocular immunology and inflammation, Jan 28, 2017
The host immune reaction during endophthalmitis, studied in particular through the intraocular cy... more The host immune reaction during endophthalmitis, studied in particular through the intraocular cytokine network, is essential for the comprehension of the disease and the development of new therapies. Therefore, the purpose of this study was to elucidate the cytokine composition of aqueous humor during endophthalmitis. In a multicenter case-control study, forty-nine patients with postoperative endophthalmitis and 60 controls (cataract surgery) were included. Visual acuity, local inflammatory grading, medical history and intraocular levels of 27 cytokines and chemokines (measured by multiplex immunoassay) were recorded. During endophtalmitis, an increase in total cytokines was observed. The raise of Th1 cytokines was particularly noticeable. Chemokines, such as IL-8, MIP-1 β, MCP-1, G-CSF and IP-10, also increased. Pearson's correlation analyses showed a poor visual prognosis with high levels of IL-8, MCP-1 and VEGF and a low level of IL-10 at admission. An increase in inflammato...
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Papers by Jean paul Berrod