Papers by Lison Rambliere
BMC Infectious Diseases
Background Few studies on neonatal severe bacterial infection are available in LMICs. Data are ne... more Background Few studies on neonatal severe bacterial infection are available in LMICs. Data are needed in these countries to prioritize interventions and decrease neonatal infections which are a primary cause of neonatal mortality. The BIRDY project (Bacterial Infections and Antimicrobial Drug Resistant among Young Children) was initially conducted in Madagascar, Senegal and Cambodia (BIRDY 1, 2012–2018), and continued in Madagascar only (BIRDY 2, 2018–2021). We present here the BIRDY 2 project whose objectives were (1) to estimate the incidence of neonatal severe bacterial infections and compare these findings with those obtained in BIRDY 1, (2) to identify determinants associated with severe bacterial infection and (3) to specify the antibiotic resistance pattern of bacteria in newborns. Methods The BIRDY 2 study was a prospective community-based mother and child cohort, both in urban and semi-rural areas. All pregnant women in the study areas were identified and enrolled. Their ne...
PLOS Medicine, Jun 6, 2023
Background AU : Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly: Antibiotic resistance i... more Background AU : Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly: Antibiotic resistance is a global public health issue, particularly in low-and middle-income countries (LMICs), where antibiotics required to treat resistant infections are not affordable. LMICs also bear a disproportionately high burden of bacterial diseases, particularly among children, and resistance jeopardizes progress made in these areas. Although outpatient antibiotic use is a major driver of antibiotic resistance, data on inappropriate antibiotic prescribing in LMICs are scarce at the community level, where the majority of prescribing occurs. Here, we aimed to characterize inappropriate antibiotic prescribing among young outpatient children and to identify its determinants in 3 LMICs. Methods and findings We used data from a prospective, community-based mother-and-child cohort (BIRDY, 2012 to 2018) conducted across urban and rural sites in Madagascar, Senegal, and
Journal of Global Health, Apr 14, 2023
Frontiers in Public Health
IntroductionPoor mental health among youth is a major public health issue that has risen to the f... more IntroductionPoor mental health among youth is a major public health issue that has risen to the forefront since the COVID-19 crisis, especially among post-secondary students and precarious populations. The objectives of this work were to evaluate the rate of major depressive disorder (MDD) among precarious post-secondary students in the greater Paris region, to describe its risk factors, and to identify determinants for not seeking care.MethodsWe conducted a multi-site, cross-sectional survey of post-secondary students attending a selection of 13 student foodbanks in the greater Paris region (France) between 30 November 2021 and 27 January 2022. This study had two complementary epidemiological and sociological components: a quantitative description of MDD through completion of a questionnaire performed through face-to-face or telephone interviews, and a qualitative assessment of the factors underlying MDD through in-depth follow-up interviews conducted among a sub-selection of stude...
Frontiers in Child and Adolescent Psychiatry
ObjectiveThis study aimed to identify the housing and psychosocial factors associated with mental... more ObjectiveThis study aimed to identify the housing and psychosocial factors associated with mental health disorders in children aged 6–12 years living in sheltered homeless families in the Greater Paris area (France), with a view to guiding the development of actions that could improve their mental health.MethodThe cross-sectional study ENFAMS (“Enfants et familles sans logement”) was conducted between January and May 2013 on a random sample of sheltered homeless families in the Greater Paris area using face-to-face questionnaires administered by trained interviewers and psychologists in 17 languages. The questionnaires collected data on socio-demographics, living conditions, and health characteristics for the child and one of the parent selected. Mental health disorders were assessed in 198 children using the Dominic Interactive tool. Statistical analyses were performed using multiple linear regression on complete data.ResultsThe Dominic Interactive mean score was 28.8 (SD = 17.5), ...
Open Forum Infectious Diseases
Background Vaccination reduces mortality from infectious disease, which is the leading cause of d... more Background Vaccination reduces mortality from infectious disease, which is the leading cause of death in children under 5 and bears a particularly high burden in low- and middle-income countries. The Global Vaccine Action Plan (2011–2020) has set a target of 90% vaccine coverage for all vaccines included in national immunization programs by 2020. The objectives of this study were to estimate vaccine coverage among children in Madagascar, Cambodia, and Senegal and to identify the risk factors associated with incomplete vaccination. Methods Using data from a community-based prospective cohort that included all newborn of some areas from 2012 to 2018 in these 3 countries, vaccine coverage was estimated for BCG, hepatitis B, oral polio, pentavalent (targeting diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type b), and measles vaccines. Risk factor analysis was performed with logistic regression models to identify correlates of incomplete vaccination. Results A t...
Les enfants de moins de 5 ans sont une population vulnérables en terme de mortalité et de morbidi... more Les enfants de moins de 5 ans sont une population vulnérables en terme de mortalité et de morbidité infectieuse dans les pays à revenu faible et modéré (PRFM). Cependant, l’incidence de ces évènements ainsi que leurs facteurs de risque sont encore mal connus. Les objectifs de cette thèse étaient de mieux documenter la morbi-mortalité chez les enfants dans les PRFM, ainsi que de discuter des interventions qui pourraient permettre de prévenir ces évènements adverses. Ce travail s’appuyait sur les données de la cohorte mère-enfant communautaire et internationale BIRDY mise en place au Cambodge, à Madagascar et au Sénégal. L’accouchement et la première semaine de vie ont été identifiés comme les périodes les plus à risque de décès. Les causes les plus fréquentes de mortalité néonatale étaient les complications à l’accouchement, la prématurité et les infections. De plus, 16% des enfants avec un évènement sérieux de santé initial présentaient une infection ultérieure dans les trois mois, ...
International Journal of Antimicrobial Agents, 2021
Erratum Erratum to "Impact of mass and systematic antibiotic administration on antibiotic resista... more Erratum Erratum to "Impact of mass and systematic antibiotic administration on antibiotic resistance in low-and middle-income countries. A systematic review" [
Social Science Research Network, 2021
International journal of antimicrobial agents, 2021
Antibiotic consumption is a key driver of antibiotic resistance (AR), particularly in low- and mi... more Antibiotic consumption is a key driver of antibiotic resistance (AR), particularly in low- and middle-income countries, where risk factors for AR emergence and spread are rife. However, the potential contribution of mass and systematic antibiotic administration (MDA/SDA) to AR spread is unknown. We conducted a systematic review to provide an overview of MDA/SDA in low- and middle-income countries, including indications, antibiotics used and, if investigated, levels of AR over time. This systematic review is reported in accordance with the PRISMA statement. Of 2438 identified articles, 63 were reviewed: indications for MDA/SDA were various, and targeted populations were particularly vulnerable, including pregnant women, children, HIV-infected populations and communities in outbreak settings. Available data suggest MDA/SDA may lead to significant AR increase, especially after azithromycin administration. However, only 40% of studies evaluated AR. Integrative approaches that evaluate A...
Uploads
Papers by Lison Rambliere