Papers by Valentina Simeon
Frontiers in Oncology
High risk multiple myeloma (HRMM) at diagnosis is currently recognized according to the Revised I... more High risk multiple myeloma (HRMM) at diagnosis is currently recognized according to the Revised International Staging System (R-ISS) which was set up in 2015. Since then, new clinical and biological prognostic factors have been developed, which could implement the definition of High Risk (HR) category. We conducted a survey in order to identify which additional parameters, both clinical and biological, are considered more useful for the clinical practice and to evaluate if the management of Multiple Myeloma (MM) should change on the basis of the risk category. A questionnaire, consisting of 8 statements, was submitted to 6 Italian experts, from the European Myeloma Network (EMN) Research Italy, using the Delphi method. The colleagues were asked to answer each question using a scale between 0 and 100. If a statement did not reach at least 75 out of 100 points from all the participants, it was rephrased on the basis of the proposal of the experts and resubmitted in a second or further...
Frontiers in Oncology, Jan 23, 2023
Objective To evaluate the pattern of cortical activation during a painful procedure, such as a ve... more Objective To evaluate the pattern of cortical activation during a painful procedure, such as a venipuncture, in children with intellectual disability and compare it with that of cognitively healthy children. Study design and setting A cohort study was conducted and cortical activation was assessed by multichannel cerebral near-infrared spectroscopy to monitor variations in oxyhaemoglobin and deoxyhaemoglobin (Hbb) in children with and without intellectual disability during a venipuncture for blood sampling with topical anaesthesia. Pain and distress were assessed as well using different validated pain scales (visual analogue scale and Non-Communicating Children’s Pain Checklist-Postoperative Version for children with intellectual disability), and compared between groups. Participants 16 children with severe to profound intellectual disability and 20 cognitively healthy peers (age range: 4–17 years). Results When Hbb was analysed, children with intellectual disability exhibited a bil...
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Papers by Valentina Simeon