Papers by Giovanni Ricevuti
Ozone Therapy, 2019
The prevention of surgical site infections is a priority within the objectives of the National He... more The prevention of surgical site infections is a priority within the objectives of the National Health System. The negative consequences of postoperative infections (morbidity, duration of hospitalization, mortality) are particularly serious events for the individual patient and for the community, given both the welfare resources needed to treat them, and the continued growth of the phenomenon of antibiotic resistance. In a global health context in which evidence-based medicine has established itself, all medical interventions must be reconsidered in the light of what can be inferred from the literature evaluated according to strict methodological criteria, all the more so when the evidence is available and unanimously shared. The future objective will be to introduce in the national guidelines a protocol involving the use of ozone therapy alongside antibiotic therapy, both in the prevention and treatment of infections, to avoid the emergence of antibiotic resistance and thus reduce ...
The Open emergency medicine journal, Sep 6, 2013
Background: antibiotic therapy and prophylaxis of epidermal wounds in emergency room are often ma... more Background: antibiotic therapy and prophylaxis of epidermal wounds in emergency room are often made empirically in case of clinics due to infective complications, although there are no scientific evidences supporting their validity yet. Furthermore, resistance to many antibiotics is a constantly growing problem, especially in Lombardy, Italy. When needed, better prefer beta-lactams or macrolides for their large-spectrum activity. Methods: We identified all patients (pts) treated to our emergency room for epidermal wounds in a period between 1st and 31st july 2012. Then, we performed a retrospective, observational analysis of epidemiological, clinical and therapeutic features of those pts. <12 years old individuals were exluded. We considered at high risk of infections pts with at least one of the following comorbidities: diabetes, neoplastic disease, therapy with corticosteroids, immunodepression. Results: A total of 201 pts were evaluated, 143 males (71.1%) and 58 females (28.9%). The median age was 46,3 yrs. Among the pts 101 (50.2%) needed treatment with suture. 13 (6.5%) pts came after at least 12 hrs after the accident. 107 (53,2%) pts did not need therapy, while in 82 (40.8%) cases antibiotic prophylaxis (89% beta-lactams, 9.8% macrolides, 1.2% others) has been prescribed; 4 (2%) were adviced to start antibiotic therapy only in case of acute epidermal infection development at home; we don't have this information about 8 pts (4%). In 185 (93.5%) pts clinical signs of acute epidermal infection were missing. 15 (7.5%) pts had an high risk of developing infections in history taking; 3 of them received antibiotic prophylaxis, 8 didn't, 4 not known. In 143 individuals (71,1%) the history taking has been insufficient. Conclusions: Even if acute local infection is possible in wounded pts, only subjects at high risk should be closely screened and monitored to detect early infection, in order to evaluate the necessity of specific antibiotic therapy. Clinical evaluation should also include comorbilities as valvulopathy or immunosuppression.
International Journal of Immunopathology and Pharmacology, May 1, 1989
The clinical syndrome of acute myocardial ischemia includes the processes of acute coronary occlu... more The clinical syndrome of acute myocardial ischemia includes the processes of acute coronary occlusion, possible reperfusion and inflammation (6,8). Each of these processes has been shown to involve granulocytes which disrupt tissues and the contractile machinery of the myocardium (3). The neutrophils are not normally sequestered in the heart; instead they are activated by processes occurring during ischemia and re-oxygenation that lead to their active accumulation. The accumulation of neutrophils is temporally, regionally, and quantitatively associated with the development of myocardial injury (2,14). Drugs, antibodies, or filters that either prevent neutrophil activation (and consequently accumulation) or deplete the blood of neutrophils diminish the area of damage and improve function after ischemia and reperfusion (13). The purpose of this brief report is to discuss the mechanism by which neutrophils may contribute to ischemia-induced myocardial injury and disfunction. Attention will be placed on the potential role of neutrophil-derived mediators in the injurious process, in particular, the metabolites of arachodonic acid (AA) and the oxygen derived free radicals. Recently, these mediators have assumed primary importance because inhibitors of AA lipoxygenation or free-radical scavengers, independently can reduce infarct size.
PubMed, 1989
Eccrine spiradenoma is a rare, usually benign tumor, originating from cutaneous sweat glands. Its... more Eccrine spiradenoma is a rare, usually benign tumor, originating from cutaneous sweat glands. Its clinical and histologic diagnosis can be difficult at times, especially when malignant features are present. Proper management requires radical surgical excision. Two cases of spiradenoma are reported, one of which highly malignant with diffuse pulmonary metastases leading to the patient's death in spite of repeated radical surgery.
PubMed, Nov 1, 1990
The authors report the clinical and biological findings of a case of a rare haematological malign... more The authors report the clinical and biological findings of a case of a rare haematological malignant entity, morphologically characterised by a bizarre nuclear abnormality in granulocytes, consisting of exaggerated chromatin clumping and apparent fragmentation of the nucleus, with a loss of segmentation. They emphasize the coexistence of proliferative and dysplastic characteristics as a distinctive marker of this disorder and suggest it may represent a distinct rare morphological entity among the atypical chronic myeloid leukaemias, Ph1 and ber negative.
International Journal of Immunopathology and Pharmacology, Jul 1, 2010
Journal of Medical Virology, Jun 30, 2021
On October 2020, Sestili and Fimognari reported that acetaminophen (N-aetyl-para-aminophenol), co... more On October 2020, Sestili and Fimognari reported that acetaminophen (N-aetyl-para-aminophenol), commonly known as paracetamol, induces or worsens glutathione (GSH) consumption in elderly patients affected by early or mild COVID-19 This article is protected by copyright. All rights reserved.
International Journal of Immunopathology and Pharmacology, Jul 1, 2005
We analyzed soluble vascular adhesion molecules (sVCAM-l), reactive oxygen metabolites (ROMs) lev... more We analyzed soluble vascular adhesion molecules (sVCAM-l), reactive oxygen metabolites (ROMs) level, total antioxidant status (TAS) and telediastolic left ventricular volume (TLVV) in patients with myocardial infarction undergoing reperfusion therapy and treated with antioxidant vitamins (AT) or placebo (P) before and for 1 month after reperfusion. After reperfusion, sVCAM-l serum concentration, reactive oxygen metabolites level, and TLVV were significantly higher in patients treated with placebo than in those treated with antioxidant vitamins, while TAS was significantly higher in patients treated with antioxidant supplementation. We observed that 48 hours after reperfusion sVCAM-l (P) vs sVCAM-l(AT) was 2.03±O.5 vs 1.63±O.7 ug/ml with p<O.Ol; ROMs (P) vs ROMs (AT) were 335.60±35.80 vs 307.50±47.10 V.CARR with p<O.05; TAS (P) vs TAS (AT) was 526.47±44.24 vs 737.65±51.15 umol/l with p<O.Ol; 1 week after reperfusion TLVV (P) vs TLVV (AT) was 125.12±29.80vs 119.40±29.40 ml with p<O.05; 1 month after reperfusion TLVV (P) vs TLVV (AV) was 132.00±33.50 vs 123.40±21.60 ml with p<O.05. In the first period after infarction, vitamin treatment improves the antioxidant system and reduces oxidative stress, inflammatory process and left ventricular remodeling. In acute myocardial infarction (AMI), the ischemic events are triggered by disruption of atheromatous plaque, with thrombus formation (1). The plaque derives from cholesterol deposition and intima infiltration from monocytes and neutrophils (PMN). The PMN generate free radicals that damage the endothelial cells and increase proinflammatory cytokines and tumour necrosis factor-alpha level (2-5). These molecules activate PMN, that play an important role in this process, by release of proteolytic enzyme and generation of oxygen free radicals, that can cause injury to membranes and mitochondria (6-10). ROS derived by PMN activation (11) may have an important role in the pathophysiology of AMI because it can induce functional and structural damage of cardiac myocytes (12-14) due to the damage of cellular membranes, proteins, mitochondria, DNA, lipoproteins, and lipid peroxydation (15-18). Moreover, reperfusion therapy after AMI can induce a response similar to the acute inflammation, with endothelial cell injury and inflammatory cell infiltration that produce further ROS (6, 19-22). AMI frequently produces left ventricular (LV) dilatation and hypertrophy of the noninfarcted
European Heart Journal Supplements, 2021
International Journal of Immunopathology and Pharmacology, Sep 1, 1988
European Heart Journal Supplements, 2021
Neural Regeneration Research, 2016
Transcranial magnetic stimulation (TMS) is a non-invasive technique used recently to treat differ... more Transcranial magnetic stimulation (TMS) is a non-invasive technique used recently to treat different neuropsychiatric and neurodegenerative disorders. Despite its proven value, the mechanisms through which TMS exerts its beneficial action on neuronal function remain unclear. Recent studies have shown that its beneficial effects may be at least partly due to a neuroprotective effect on oxidative and cell damage. This study shows that TMS can modulate the Nrf2 transcriptor factor in a Huntington's diseaselike rat model induced by 3-nitropropionic acid (3-NP). Western blot analysis demonstrated that 3-NP caused a reduction in Nrf2 in both cytoplasm and nucleus, while TMS applied to 3-NP-treated rats triggered an increase in cytoplasm and nucleus Nrf2 levels. It was therefore concluded that TMS modulates Nrf2 expression and translocation and that these mechanisms may partly explain the neuroprotective effect of TMS, as well as its antioxidant and cell protection capacity.
Aging Clinical and Experimental Research, Oct 7, 2016
Case Reports in Medicine, 2016
Introduction. A number of studies suggest that oxygen-ozone therapy may have a role in the treatm... more Introduction. A number of studies suggest that oxygen-ozone therapy may have a role in the treatment of chronic, nonhealing, or ischemic wounds for its disinfectant and antibacterial properties. Nonhealing wounds are a significant cause of morbidity. Here we present a case of subcutaneous oxygen-ozone therapy used to treat a nonhealing postoperative wound in a young man during a period of 5 weeks. Case Presentation. A 46-year-old man had a motorcycle accident and underwent amputation of the right tibia and fibula. At the discharge he came to our attention to start rehabilitation treatment. At that time the wound was ulcerated but it was afebrile with no signs of inflammation and negativity to blood tests. At 2 months from the trauma despite appropriate treatment and dressing, the wound was slowly improving and the patient complained of pain. For this reason in addition to standard dressing he underwent oxygen-ozone therapy. After 5 weeks of treatment the wound had healed. Conclusion. In patients with nonhealing wounds, oxygen-ozone therapy could be helpful in speeding the healing and reducing the pain thanks to its disinfectant property and by the increase of endogenous oxygen free radicals' scavenging properties. Compared to standard dressing and other treatments reported in the literature it showed a shorter time of action.
International Immunopharmacology, Jul 1, 2021
An increasing amount of reports in the literature is showing that medical ozone (O3) is used, wit... more An increasing amount of reports in the literature is showing that medical ozone (O3) is used, with encouraging results, in treating COVID-19 patients, optimizing pain and symptoms relief, respiratory parameters, inflammatory and coagulation markers and the overall health status, so reducing significantly how much time patients underwent hospitalization and intensive care. To date, aside from mechanisms taking into account the ability of O3 to activate a rapid oxidative stress response, by up-regulating antioxidant and scavenging enzymes, no sound hypothesis was addressed to attempt a synopsis of how O3 should act on COVID-19. The knowledge on how O3 works on inflammation and thrombosis mechanisms is of the utmost importance to make physicians endowed with new guns against SARS-CoV2 pandemic. This review tries to address this issue, so to expand the debate in the scientific community.
DOAJ (DOAJ: Directory of Open Access Journals), Apr 1, 2020
Ozone therapy, Apr 11, 2019
The prevention of surgical site infections is a priority within the objectives of the National He... more The prevention of surgical site infections is a priority within the objectives of the National Health System. The negative consequences of postoperative infections (morbidity, duration of hospitalization, mortality) are particularly serious events for the individual patient and for the community, given both the welfare resources needed to treat them, and the continued growth of the phenomenon of antibiotic resistance. In a global health context in which evidence-based medicine has established itself, all medical interventions must be reconsidered in the light of what can be inferred from the literature evaluated according to strict methodological criteria, all the more so when the evidence is available and unanimously shared. The future objective will be to introduce in the national guidelines a protocol involving the use of ozone therapy alongside antibiotic therapy, both in the prevention and treatment of infections, to avoid the emergence of antibiotic resistance and thus reduce the expenditure of the national health system.
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Papers by Giovanni Ricevuti