Papers by Andrea Trevisan
Vaccine, Dec 1, 2013
Despite hepatitis B virus (HBV) immunization, a percentage of healthy individuals display an anti... more Despite hepatitis B virus (HBV) immunization, a percentage of healthy individuals display an antibody titre below the threshold for clinical protection (10 IU/L). In order to predict the existence of this inducible immunological response, the precise anti-HBs titre required to achieve protection in immunized patients with waned HBs antibodies must first be determined. A total of 4486 vaccinated students attending the University of Padova Medical, Science, and Veterinary School were recruited for study between 2004 and early 2012. The baseline concentration of anti-HBs was measured at enrolment. Participants displaying anti-HBs titre <10 IU/L at the follow-up examination (mean 10.8 years) were given a booster vaccination and retested 20-30 days later. At enrolment, 87.6% of the 4486 vaccinated subjects showed persistence of anti-HBs higher than 10 IU/L. Of the 279 booster-vaccinated subjects, 94.6% achieved the cutoff titre. Booster-induced immunological response was correlated to the pre-booster titre level, with ≥2 IU/L ensuring a robust positive response and less than 2 IU/L being associated with the probability of developing insufficient levels of antibodies. Pre-booster antibody titre higher than 2 IU/L in adults might be predictive of an anamnestic response to booster vaccination, whereas titres below this value may indicate likelihood of non-response.
Science of The Total Environment, 1991
Transport Policy, 2016
Automobiles are an important source of carbon dioxide (CO 2) and other greenhouse gases (GHG) inv... more Automobiles are an important source of carbon dioxide (CO 2) and other greenhouse gases (GHG) involved in climate change and human health impairment. Correct information on the environmental impact of cars in terms of CO 2 emissions and fuel consumption is necessary in car advertisements. The purpose of this paper is to evaluate the completeness of information on CO 2 emissions and fuel consumption in car advertisements according to the 1999/94/EC European Directive. We examined 902 car advertisements published in a monthly Italian car magazine searching for data on CO 2 emissions and fuel consumption according to 1999/94/EC Directive and also on further characteristics, such as type of car, engine size and power, power supply and compliance with European antipollution legislation. Our data showed only partial adherence to the statutory provisions of 1999/94/EC Directive: data on CO 2 emissions and fuel consumption were published with a high frequency, but they were referred to the specific car advertised in only a low percentage of ads, with relevant differences among car manufacturers. This makes difficult to compare the CO 2 emissions and fuel consumption of different cars to potential buyers. Full adherence to all provisions of the abovementioned Directive by all car manufacturers is desirable to provide consumers comprehensive and transparent information on the environmental performance of cars. The easiest and most effective way for a full and correct application of 1999/94/EC Directive is the introduction in ads of a label, similar to that currently in use for refrigerators and tires, reporting for each car advertised the official fuel consumption and official specific CO 2 emissions figures.
World Journal of Gastroenterology, 2013
Hepatitis C virus (HCV) infection after biological accident (needlestick injury) is a rare event.... more Hepatitis C virus (HCV) infection after biological accident (needlestick injury) is a rare event. This report describes the first case of acute HCV infection after a needlestick injury in a female nursing student at Padua University Hospital. The student nurse was injured on the second finger of the right hand when recapping a 23-gauge needle after taking a blood sample. The patient who was the source was a 72-year-old female with weakly positive anti-HCV test results. Three months after the injury, at the second step of followup, a relevant increase in transaminases with a low viral replication activity (350 IU/mL) was observed in the student, indicating HCV infection. The patient tested positive for the same genotype (1b) of HCV as the injured student. A rapid decline in transaminases, which was not accompanied by viral clearance, and persistently positive HCV-RNA was described 1 mo later. Six months after testing positive for HCV, the student was treated with pegylated interferon plus ribavirin for 24 wk. A rapid virological response was observed after 4 wk of treatment, and a sustained virological response (SVR) was evident 6 mo after therapy withdrawal, confirming that the patient was definitively cured. Despite the favourable IL28B gene (rs12979860) CC-polymorphism observed in the patient, which is usually predictive of a spontaneous clearance and SVR, spontaneous viral clearance did not take place; however, infection with this genotype was promising for a sustained virological response after therapy.
Journal of drug metabolism & toxicology, 2011
This article was originally published in a special issue, Biotransformations & Toxicology handled... more This article was originally published in a special issue, Biotransformations & Toxicology handled by Editor(s). Dr. Eric A.G. Blomme, Abbott Laboratories, USA
American Journal of Industrial Medicine, 1990
Objective: Concern exists regarding the possible hazards to the personnel handling antineoplastic... more Objective: Concern exists regarding the possible hazards to the personnel handling antineoplastic drugs. The purpose of the present study was to assess the genotoxicity induced by anti-neoplastic agents in oncology department personnel. Materials and methods: To do this, the frequency of chromosomal aberrations (CAs) induced in peripheral blood lymphocytes was assessed at G 0 phase of the cell cycle using metaphase analysis, cytokinesis block-micronucleus (MN) assay and sister chromatid exchange (SCE) assay. These cytogenetic end points were measured among 71 nurses in oncology department and 10 drugstore personnel handling and preparing anti-neoplastic drugs. The results were compared to those of 74 matched nurses for age and sex not exposed to any anti-neoplastic agents. Results: There was no significant difference between the age of study subjects and control group (p40.05). The results showed that the mean frequency of cytogenetic damages in terms of CAs [chromatid breaks (p ¼ 0.01), chromosome breaks (p ¼ 0.005), total CAs (p ¼ 0.001)], MN formation (p ¼ 0.001), and SCE (p ¼ 0.004) in lymphocytes of personnel handling anti-neoplastic drugs were significantly higher than those in control unexposed group. Conclusion: Results of the present study demonstrate the cytogenetic damage in peripheral blood lymphocytes of oncology department personnel. Suitable training and proper knowledge when handling anti-neoplastic drugs are emphasized to avoid potential health hazards caused by cytostatic agents.
Atla-alternatives To Laboratory Animals, Sep 1, 1995
Department of Medicine & Therapeutics and Department of Biomedical Sciences, Polwarth Buildin... more Department of Medicine & Therapeutics and Department of Biomedical Sciences, Polwarth Building, University of Aberdeen, Aberdeen AB9 2ZD, UK; Faculty of Science, University of East London, Romford Road, London E15 4LZ, UK; LADCR, Division of Toxicology, Center for Rio-Pharmaceutical Sciences, Leiden University, 2300 RA Leiden, The Netherlands; Universitat Wurzburg, Versbacherstrasse 9, 97074 Wurzburg, Germany; /nstitut de Pharmacologie et de Toxicologie de l'Universite, rue de Bugnon 27, 1005 Lausanne, Switzerland; 8Sanofi-Winthrop Research Centre, Willowburn Avenue, Alnwick, Northumberland NE66 2JH, UK; ZENECA Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SKID 4TJ, UK; Department of Biological Sciences, University of Paisley, High Street, Paisley PAl 2BE, UK; /NSERM U295, Uer Medicine Phar.macie, Universite de Rouen, 76803 Saint Etienne Rouvray, France; /nstitut'filr Physiolo1ie zmd Balneologie, Universitiit Innsbruck, Fritz-Preglstrasse 3, 6010 Innsbruck, Austria; 3TNO Nutrition and Food Research Institute, Division of Toxicology, 3700 AJ Zeist, The Netherlands; 14Department ofs Pharmacology, University College Dublin, Fosters Avenue, Blackrock, Dublin, Ireland; 5Rh0ne-Poulenc Rorer, Centre de Recherche de Vitry, 13 Quai Jules Guisde, 94405 Vitry Cedex, France; /nstituto di Medicina del Lavoro, Universita di Padova, Via Facciolati 71, 35127 Padova, Italy
Journal of Inorganic Biochemistry, 2003
This work reports on the synthesis, characterization and biological activity of new coordination ... more This work reports on the synthesis, characterization and biological activity of new coordination compounds of the type [M(TSDTM)X ] (M5Pt(II), Pd(II); X5Cl, Br; TSDTM5ter-butylsarcosine(S-methyl)dithiocarbamate) and [Pd(TSDT)X] (TSDT5ter-2 n butylsarcosinedithiocarbamate) in order to study their behavior as potential antitumor agents. All the synthesized compounds were 1 1 3 characterized by means of elemental analysis, FT-IR, H and C-NMR spectroscopy and thermogravimetric analysis, suggesting a chelate S,S9 structure of the TSDTM / TSDT ligand in a square-planar geometry. Finally, the synthesized complexes have been tested for in vitro cytotoxic activity against human leukemic HL60 and adenocarcinoma HeLa cells; the most active compound [Pt(TSDTM)Br ], 2 characterized by IC values very similar to those of the reference compound (cisplatin), was also tested for in vitro nephrotoxicity 50 showing a very low renal cytotoxicity as compared to cisplatin itself.
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Papers by Andrea Trevisan