Papers by Trevor R Norman
Medical Journal of Australia, 1996
Journal of Neurology, Neurosurgery & Psychiatry, 1982
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Australasian Psychiatry, Jan 28, 2022
Objective: To investigate whether diagnostic agreement and concordance between non-psychiatric (m... more Objective: To investigate whether diagnostic agreement and concordance between non-psychiatric (medical and surgical) doctors and consultation-liaison psychiatry changes within junior doctors’ terms. Method: This was a retrospective cohort analysis of referrals from medical and surgical units to a consultation-liaison psychiatry service. Diagnostic agreement was calculated across all diagnoses and expressed as a percentage. Diagnostic concordance (expressed using Cohen’s Kappa) was calculated for the two most common diagnoses of depression and delirium. Diagnostic agreement and concordance in the first two weeks (Timepoint A) were compared to those in the last two weeks (Timepoint B) of junior doctors’ terms. Results: Around half the referrals (Timepoint A = 48.1%, Timepoint B = 54.0%) were excluded as no diagnosis was listed. Diagnostic agreement over all diagnoses was 31.7% (Timepoint A) and 29.9% (Timepoint B) and was not statistically different. Diagnostic concordance for depression increased from fair to moderate but was not statistically significant. Diagnostic concordance for delirium was substantial for both timepoints and were not statistically different. Conclusions: No statistically significant change in diagnostic accuracy over a junior doctors’ term was found in this study.
Taylor & Francis eBooks, Feb 16, 2010
Journal of Chromatography B: Biomedical Sciences and Applications, May 1, 1985
Solid-phase microextraction coupled to liquid chromatography and mass spectrometry (SPME-LC-MS) w... more Solid-phase microextraction coupled to liquid chromatography and mass spectrometry (SPME-LC-MS) was used to analyze tricyclic antidepressant drugs desipramine, imipramine, nortriptyline, amitriptyline, and clomipramine (internal standard) in plasma samples. SPME was performed by direct extraction on a PDMS/DVB (60 µm) coated fiber, employing a stirring rate of 1200 rpm for 30 min, pH 11.0, and temperature of 30°C. Drug desorption was carried out by exposing the fiber to the liquid chromatography mobile phase for 20 min, using a labmade SPME-LC interface at 50°C. The main variables experimentally influencing LC-MS response were evaluated and mathematically modeled. A rational optimization with fewer experiments was achieved using a factorial design approach. The constructed empirical models were adjusted with 96-98% of explained deviation allowing an adequate data set comprehension. The chromatographic separation was realized using an RP-18 column (150 mm × 2.1 mm, 5 µm particles) and ammonium acetate buffer (0.01 mol/l, pH 5.50) : acetonitrile (50 : 50 v/v) as mobile phase. Low detection levels were achieved with electrospray interface (0.1 ng/ml). The developed method showed specificity, linearity, precision, and limit of quantification adequate to assay tricyclic antidepressant drugs in plasma.
Chemischer Informationsdienst, Sep 16, 1975
ii, 181 leaves : ill. ; 25 cm.Thesis (Ph.D.) -- University of Adelaide, Dept. of Physical and Ino... more ii, 181 leaves : ill. ; 25 cm.Thesis (Ph.D.) -- University of Adelaide, Dept. of Physical and Inorganic Chemistry, 197
Current Therapeutics, 1997
Depression is a common disorder (lifetime prevalence approximately 17%) with significant morbidit... more Depression is a common disorder (lifetime prevalence approximately 17%) with significant morbidity and mortality. The suicide rate in depressed patients may be up to 15%. The presence of depressed mood is not sufficient to constitute a diagnosis of depressive disorder. Asking direct questions that probe for the main symptoms of depression helps ensure the diagnosis is not missed. Major depressive disorder tends to be a chronic condition with frequent relapses. The presence of a comorbid psychiatric disorder and a history of more than one previous depressive episode are indicators of a poor prognosis. When referral for depression is considered necessary, patients must be informed that it is to a psychiatric clinic. (author abstract)
BENTHAM SCIENCE PUBLISHERS eBooks, Dec 15, 2016
The Medical Journal of Australia, Oct 1, 1983
We report a case of schizophreniform illness, which occurred after the withdrawal of steroid ther... more We report a case of schizophreniform illness, which occurred after the withdrawal of steroid therapy. Despite the withdrawal of steroids, the patient's illness persisted and she required symptomatic treatment with phenothiazines and electroconvulsive therapy. The specific role of steroids in the causation of these illnesses is not clear, and may have implications for the aetiology of schizophrenia. Cases such as this have been reported only rarely in the literature.
PubMed, 1998
Reboxetine is a unique selective norepinephrine reuptake inhibitor (NRI) with proven antidepressa... more Reboxetine is a unique selective norepinephrine reuptake inhibitor (NRI) with proven antidepressant efficacy in pharmacologic and biochemical tests predictive of antidepressant properties. Comprehensive clinical trials, including 8 placebo-controlled and/or active treatment-controlled studies, plus 4 open studies, have assessed the short-term and long-term efficacy and tolerability of reboxetine in patients with major depressive disorders and dysthymia. Results from a total of 690 patients who entered 5 open or placebo-controlled studies are summarized in this paper. Four hundred forty-nine patients with a diagnosis of either major depressive disorder or dysthymia were treated with reboxetine in these clinical studies of 4 weeks' to 12 months' duration. In a 6-week placebo-controlled study, clinically significant improvement (> or = 50% reduction in Hamilton Rating Scale for Depression total score) was observed at last assessment in 74% of reboxetine-treated patients compared with 20% of patients in the placebo group. Similar results were observed in the 6-week run-in phases of the 3 long-term studies, where the efficacy of reboxetine was maintained over the 12-month study period. Reboxetine was well tolerated; adverse events reported were mainly mild to moderate in severity, and there were no clinically significant changes in vital signs or laboratory parameters. The first in its class, reboxetine, a selective NRI, will provide a valuable addition to the existing armamentarium of agents used in the treatment of depression.
Biological Psychiatry, 2008
Australian and New Zealand Journal of Psychiatry, Jun 2, 2023
The Medical Journal of Australia, May 1, 1993
Cambridge University Press eBooks, May 5, 2016
Journal of Affective Disorders, Jun 1, 1982
Loxapine, amoxapine and their 8-hydroxylated derivatives were studied by means of [3H]imipramine ... more Loxapine, amoxapine and their 8-hydroxylated derivatives were studied by means of [3H]imipramine binding to rat cortical membranes, [3H]spiperone binding to rat striatal membranes, and the inhibition of serotonin uptake by human platelets. As inhibitors of [3H]imipramine binding: amoxapine greater than hydroxyamoxapine greater than loxapine = hydroxyloxapine; as inhibitors of platelet serotonin uptake: hydroxyamoxapine greater than amoxapine greater than hydroxyloxapine greater than loxapine; and as inhibitors of [3H]spiperone binding: loxapine greater than amoxapine greater than hydroxyamoxapine greater than hydroxyloxapine. The antipsychotic properties of loxapine and amoxapine were supported by the binding results, which also indicated the probable antipsychotic activities of the metabolites. All 4 compounds may possess dual action of antidepressant effect as well as antipsychotic effect.
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Papers by Trevor R Norman