Papers by Mohamad Syahmi Shahril
AYU (An International Quarterly Journal of Research in Ayurveda), 2013
Hepatoprotective activity of methanolic extract of Syzygium jambos (Alston) (Linn.) leaves agains... more Hepatoprotective activity of methanolic extract of Syzygium jambos (Alston) (Linn.) leaves against Paracetamol-induced hepatic damage in Wistar albino rats was observed at two different doses, 100 and 200 mg/kg body weight. The healthy control, disease control, and standard drug Silymarin-treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALKP, Serum Bilirubin and other metabolic parameters like total cholesterol, HDL-cholesterol were evaluated in all the experimental groups. The changes in liver function parameters were significant in comparison to disease control group and the observed efficacy was comparable to standard drug. The efficacy of the extract was found to be dose dependent. The histopathology study of liver also supports the presence of hepatoprotective activity in S. jambos by showing improved cytoarchitecture of liver cells in the treated groups. The results obtained in this study indicate necessity for further research on isolation and characterization of functional molecules from the extract.
Therapeutic and new alternative potential compounds of natural product have been widely used in p... more Therapeutic and new alternative potential compounds of natural product have been widely used in pharmaceutical industry. Interest on alternative efforts to search for new compounds with less or no adverse effects has led to the discovery of new potential plants in the treatment of diseases. Erythroxylum cuneatum, also known as „Chinta Mula‟ plant among Malaysians has been discovered and recently proven to possess antiwithdrawal properties with a potential to be explored as a source of new drugs for the treatment of addiction. Erythroxylum cuneatum can be found in primary and secondary forests. Due to less information on this plant, this elusive plant was investigated advancely to understand its roles and potential as a new source of pharmacologically in the pharmaceutical industry. Thus, further scientific exploration was made to understand the mechanisms of action involving toxicity and neurobehavioral properties were proposed. Three different extracts were produced from the leaves...
Erythroxylum cuneatum has been traditionally proven to possess beneficial properties in treating d... more Erythroxylum cuneatum has been traditionally proven to possess beneficial properties in treating drug addiction and other illness. Due to less information on this plant, this elusive plant was investigated further to evaluate the in vivo toxicity profile of the plant and to investigate the effect of E. cuneatum on cognitive performance in rats. Two different extracts were produced from the leaves of E. cuneatum which were aqueous and alkaloid extracts. Acute in vivo toxicity test was evaluated in ICR mice to determine their medium lethal dose 50 value. In the in-vivo toxicity study, aqueous extract showed the almost similar toxic effect as alkaloid extract which was 416.86 mg/kg for alkaloid extract and 316.23 mg/kg for aqueous extract. These findings suggesting that aqueous and alkaloid extracts showed toxic effects at the high dose, thus safe at a low dose. Working memory task using novel object discrimination test (NOD) was performed for the determination of neurobehavioral profiles....
The objective of the present study was to determine the hepatoprotective activity of methanol ext... more The objective of the present study was to determine the hepatoprotective activity of methanol extract of Bauhinia purpurea L. leaves (MEBP ; family Fabaceae) using paracetamol and carbon tetrachloride induced liver toxicity models. The dried, ground leaves of B.purpurea (40g) were soaked with 800ml methanol (1:20 (w/v)) for 72h at room temperature, filtered and subjected to the rotary evaporation process. This processes were repeated three times. The vehicle (10% DMSO), 200mg/kg silymarin or MEBP (50, 250 and 500 mg/kg) were administered orally once daily for 7 consecutive days in rats (n=6). Hepatotoxicity was induced by administration of CC14- (0.15 ml/kg) or PCM (3g/kg) 3 hours after the last extract administration. On the 9th day, the animals were sacrificed and the liver was collected for histopathological examination. From the histological observation, hepatic steatosis, lymphocyte infiltration and marked necrosis was observed in CC14 and PCM-treated groups (negative control)....
Advances in Visual Informatics
The global fatality caused by the deadly COVID-19 already took 4.5 million lives and is still rap... more The global fatality caused by the deadly COVID-19 already took 4.5 million lives and is still rapidly increasing. At the same time, Malaysian citizens have been inundated with the overabundance of news and information about COVID-19 since it hit the world in December 2019. Recent study by ISIS Malaysia discovered that WhatsApp and Facebook are the most used social media for misinformation at 39% and 34%, respectively. This phenomenon is termed as an infodemic which occurs when there is an excessive amount of information with undetermined level of accuracy. Hence, this situation makes it difficult for people to find reliable and truthful sources of information when they require it. Infodemiology is the scientific term used to describe the massive spread of information in a digital format particularly on the Internet which aims to guide the stakeholders such as the government on public health policy. Artificial Intelligence (AI) techniques hold potential solutions to address infodemic issue. This paper conceptualizes an Infodemiology Framework for COVID-19 and future pandemics towards addressing the proliferation of misinformation and disinformation on the Internet. Leveraging on AI techniques such as classification via clustering and decision tree algorithms, the research works will be conducted in five phases beginning with dataset collection phase, model building and algorithm selection phase, model refinement phase, model verification phase, and the model deployment phase. The proposed infodemiology framework has the potential to be integrated into the nation’s healthcare data warehousing system, the Malaysian Health Data Warehouse (MyHDW). © 2021, Springer Nature Switzerland AG.
BMC Complementary and Alternative Medicine, 2013
Like all articles in BMC journals, this peer-reviewed article can be downloaded, printed and dist... more Like all articles in BMC journals, this peer-reviewed article can be downloaded, printed and distributed freely for any purposes (see copyright notice below). Articles in BMC journals are listed in PubMed and archived at PubMed Central. For information about publishing your research in BMC journals or any BioMed Central journal, go to
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Papers by Mohamad Syahmi Shahril