Books by Lucretia Petersen
Papers by Lucretia Petersen
Frontiers in rehabilitation sciences, Feb 26, 2024
The impact of acquiring hearing loss might be exacerbated during adolescence, as this normal tran... more The impact of acquiring hearing loss might be exacerbated during adolescence, as this normal transition from childhood to adulthood is characterised by identity construction and social intensity. This study aimed to describe the lived experiences of South African adolescents with acquired hearing loss following aminoglycoside treatment for multidrug resistant tuberculosis. Design: The study adopted a descriptive phenomenological design and indepth, semi-structured interviews were conducted in English, isiZulu and Afrikaans. The data was managed and analysed according to a modified version of Hycner's framework. Study sample: Six participants aged 16-24 years with bilateral, mild to profound hearing loss acquired from aminoglycoside treatment were recruited from two South African provinces. Results: Three themes emerged which created a triple burden for participants. They endured socioeconomic hardship encompassing limited economic and emotional support. Participants battled the consequences of life-threatening MDR-TB including illness, hospitalisation, stigma, and other challenges. Finally, participants were left with life-changing hearing loss. Conclusion: The findings indicate the necessity of holistic management of adolescents with aminoglycoside-related acquired hearing loss and serves as motivation to improve ototoxic monitoring practices and patient uptake of monitoring services and calls for the cessation, or at least cautious use, of aminoglycosides.
South African Family Practice, Mar 1, 2015
This article aims to inform the reader about current knowledge of the effects of aminoglycosides ... more This article aims to inform the reader about current knowledge of the effects of aminoglycosides on hearing. The hearing loss caused by aminoglycosides is permanent and can negatively affect the individual’s quality of life. Although treatment with aminoglycosides cannot be avoided in some instances, timely intervention can minimise the impact of the hearing loss on the individual’s everyday life. The discussion includes the incidence of aminoglycoside-induced hearing loss and predisposing factors. In addition, monitoring and management of cochlear ototoxicity is described.
Includes bibliographical references (leaves 116-131)
International Journal of Diabetes in Developing Countries, Jun 20, 2018
South Africa has one of the highest diabetes prevalence numbers in Sub-Saharan Africa with more t... more South Africa has one of the highest diabetes prevalence numbers in Sub-Saharan Africa with more than 2 million diagnosed. There is an increase in evidence linking diabetes with hearing loss. This study aimed to determine prevalence and characterize the nature of hearing loss in patients with diabetes. An observational matched groups design was utilized with a total of 192 participants, 110 patients with diabetes (cohort) and 82 patients without diabetes (control). Pure tone audiometry findings showed a significantly higher prevalence of hearing loss in those with diabetes (55%) when compared to those without (20%) diabetes (p < .001). Further, in patients with diabetes (and diagnosed with hearing loss), the majority (74%) presented with sensorineural hearing loss. There was a higher number of participants with disabling hearing loss (pure tone average (PTA) 0.5, 1, 2 and 4 kHz > 41-dB hearing level (HL) in the better ear) in those with diabetes (n = 48) than those without (n = 10). Distortion product otoacoustic emission assessments showed significantly higher percentages of abnormalities (p < 0.01) in those with diabetes compared to those without diabetes. Findings of this study showed that participants who were diagnosed with diabetes had a higher proportion of disabling hearing loss when compared to those without diabetes. The findings of this study further strengthen the suggestion that hearing loss should be considered as a comorbidity associated with diabetes.
2023 IST-Africa Conference (IST-Africa)
<b>Purpose: </b>Specific classes of antibiotics, such as aminoglycosides, have well-e... more <b>Purpose: </b>Specific classes of antibiotics, such as aminoglycosides, have well-established adverse events producing permanent hearing loss, tinnitus, and balance and/or vestibular problems (i.e., ototoxicity). Although these antibiotics are frequently used to treat pseudomonas and other bacterial infections in patients with cystic fibrosis (CF), there are no formalized recommendations describing approaches to implementation of guideline adherent ototoxicity monitoring as part of CF clinical care.<b>Method: </b>This consensus statement was developed by the International Ototoxicity Management Working Group (IOMG) Ad Hoc Committee on Aminoglycoside Antibiotics to address the clinical need for ototoxicity management in CF patients treated with known ototoxic medications. These clinical protocol considerations were created using consensus opinion from a community of international experts and available evidence specific to patients with CF, as well as published national and international guidelines on ototoxicity monitoring.<b>Results: </b>The IOMG advocates four clinical recommendations for implementing routine and guideline adherent ototoxicity management in patients with CF. These are (a) including questions about hearing, tinnitus, and balance/vestibular problems as part of the routine CF case history for all patients; (b) utilizing timely point-of-care measures; (c) establishing a baseline and conducting posttreatment evaluations for each course of intravenous ototoxic drug treatment; and (d) repeating annual hearing and vestibular evaluations for all patients with a history of ototoxic antibiotic exposure.<b>Conclusion: </b>Increased efforts for implementation of an ototoxicity management program in the CF care team model will improve identification of ototoxicity signs and symptoms, allow for timely therapeutic follow-up, and provide the clinician and patient an opportunity to make an informed decision about potential treatment modifications to minimize adverse events.<br><b>Supplemental Material S1. </b>S [...]
Includes bibliographical references (leaves 116-131)
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2007
Human rights are social or material entitlements which are recognised universally in national and... more Human rights are social or material entitlements which are recognised universally in national and international law and that address fundamental human needs. They inhere in all people by virtue of their humanity, and represent a standard to which governments can be held accountable.
American Journal of Audiology, 2021
Purpose Specific classes of antibiotics, such as aminoglycosides, have well-established adverse e... more Purpose Specific classes of antibiotics, such as aminoglycosides, have well-established adverse events producing permanent hearing loss, tinnitus, and balance and/or vestibular problems (i.e., ototoxicity). Although these antibiotics are frequently used to treat pseudomonas and other bacterial infections in patients with cystic fibrosis (CF), there are no formalized recommendations describing approaches to implementation of guideline adherent ototoxicity monitoring as part of CF clinical care. Method This consensus statement was developed by the International Ototoxicity Management Working Group (IOMG) Ad Hoc Committee on Aminoglycoside Antibiotics to address the clinical need for ototoxicity management in CF patients treated with known ototoxic medications. These clinical protocol considerations were created using consensus opinion from a community of international experts and available evidence specific to patients with CF, as well as published national and international guideline...
International Journal of Audiology, 2019
Objective: The toxicity associated with the use of kanamycin includes irreversible hearing loss. ... more Objective: The toxicity associated with the use of kanamycin includes irreversible hearing loss. There are limited data describing the relationship between hearing loss and kanamycin pharmacokinetics (PK). We explored the association of kanamycin PK with hearing loss in patients on MDR-TB treatment. Design: We prospectively recruited patients on kanamycin-based MDR-TB treatment in Cape Town. Hearing thresholds from 0.25 to 16 kHz were tested at baseline and at 4, 8 and 12 weeks. We determined kanamycin concentrations at steady-state in serial plasma samples over 10 h, and explored factors associated with hearing loss. Study sample: One hundred and two participants including 58 (56.9%) men had analysable audiometric data; median age was 34.9 years, 65 (63.7%) were HIV-positive, and 24 (23.5%) had been treated for MDR-TB previously. Results: Eighty-four participants (82.4%) developed hearing loss. We found a 3% (95% CI: 1-6%, p ¼ 0.028) increased risk of cochleotoxicity for each 10 mg h/L increase in 0-10 h AUC. Conclusion: We describe a high incidence of hearing loss in MDR-TB patients treated with kanamycin, with higher AUC 0-10 significantly associated with hearing loss.
International Journal of Diabetes in Developing Countries, 2018
South Africa has one of the highest diabetes prevalence numbers in Sub-Saharan Africa with more t... more South Africa has one of the highest diabetes prevalence numbers in Sub-Saharan Africa with more than 2 million diagnosed. There is an increase in evidence linking diabetes with hearing loss. This study aimed to determine prevalence and characterize the nature of hearing loss in patients with diabetes. An observational matched groups design was utilized with a total of 192 participants, 110 patients with diabetes (cohort) and 82 patients without diabetes (control). Pure tone audiometry findings showed a significantly higher prevalence of hearing loss in those with diabetes (55%) when compared to those without (20%) diabetes (p < .001). Further, in patients with diabetes (and diagnosed with hearing loss), the majority (74%) presented with sensorineural hearing loss. There was a higher number of participants with disabling hearing loss (pure tone average (PTA) 0.5, 1, 2 and 4 kHz > 41-dB hearing level (HL) in the better ear) in those with diabetes (n = 48) than those without (n = 10). Distortion product otoacoustic emission assessments showed significantly higher percentages of abnormalities (p < 0.01) in those with diabetes compared to those without diabetes. Findings of this study showed that participants who were diagnosed with diabetes had a higher proportion of disabling hearing loss when compared to those without diabetes. The findings of this study further strengthen the suggestion that hearing loss should be considered as a comorbidity associated with diabetes.
The Journal of Laryngology & Otology, 2018
ObjectivesThis article attempts to highlight the challenges and possibilities for hearing healthc... more ObjectivesThis article attempts to highlight the challenges and possibilities for hearing healthcare through technology and aural rehabilitation in a resource-constrained setting, using South Africa as an example.Results and conclusionThe authors argue that it is possible to enhance service delivery by using free resources and maximising the limited existing resources. In order to provide a sustainable hearing healthcare service in developing countries, it is pertinent to understand the context where the services are needed, and not just adopt an approach developed for a different context. Audiologists in such settings need to employ strategies to develop context-specific tools, and adapt existing tools to serve the needs of the local population. Some examples, although not exhaustive, are provided in the article.
South African Family Practice, 2015
This article aims to inform the reader about current knowledge of the effects of aminoglycosides ... more This article aims to inform the reader about current knowledge of the effects of aminoglycosides on hearing. The hearing loss caused by aminoglycosides is permanent and can negatively affect the individual's quality of life. Although treatment with aminoglycosides cannot be avoided in some instances, timely intervention can minimise the impact of the hearing loss on the individual's everyday life. The discussion includes the incidence of aminoglycoside-induced hearing loss and predisposing factors. In addition, monitoring and management of cochlear ototoxicity is described.
South African Medical Journal, 2015
International Journal of Pediatric Otorhinolaryngology, 2015
Prostaglandin F2a (PGF) treatment is routinely used in the reproductive management of mares to in... more Prostaglandin F2a (PGF) treatment is routinely used in the reproductive management of mares to induce luteolysis and allow a subsequent return to estrus. The objective of this retrospective study was to assess the effect of follicle size at the time of administration of cloprostenol on interval to subsequent ovulation. A secondary objective was to determine the incidence of hemorrhagic anovulatory follicle (HAF) formation after PGF administration. Reproductive records of 275 mares monitored over a total of 520 estrous cycles were evaluated. All mares received a single intramuscular dose of 250 mg of the synthetic PGF analog cloprostenol sodium between days 5 and 12 after ovulation. The average interval from PGF to ovulation was 8.4 AE 2.5 days. The interval from PGF administration to subsequent ovulation was inversely proportional to the diameter of the largest follicle at the time of treatment. Administration of cloprostenol to mares with a large (!35 mm in diameter) diestrous follicle resulted in one of three outcomesdovulation within 48 hours (13.4%) with variable uterine edema, ovulation after 48 hours usually accompanied by the presence of uterine edema (73.1%), or regression without ovulation followed by emergence and eventual ovulation of a new dominant follicle (13.4%). There was no effect of mare age or season on interval from PGF to ovulation. The overall incidence of HAF development after PGF administration in this study was low (2.5%).
Noise and Health, 2011
South African Premier Soccer League (PSL) matches are known worldwide as some of the noisiest rec... more South African Premier Soccer League (PSL) matches are known worldwide as some of the noisiest recreational events. Therefore, the objectives of this study were to i) measure noise levels during different PSL matches; ii) measure changes in auditory function after attending PSL matches; and iii) determine the factors that increase the risk of overexposure to noise during PSL matches. The study used a descriptive quantitative analytical pre- and post-exposure design. Participants (n = 19, and n = 10) attended two PSL matches. Each participant&amp;amp;amp;amp;#39;s auditory function was assessed using distortion product oto-acoustic emissions (DPOAEs) before and after attending a PSL match. Peak and equivalent continuous noise levels as well as noise dose were measured during each match. Noise levels recorded during the poorly attended Match 1 were lesser than those of the well-attended Match 2. Participants attending Match 2 had statistically significant reduction in their DPOAE amplitudes after the match (P = 0.003) than those attending Match 1. Vuvuzela blowers and participants seated within 1 m from them were most at risk of harm to their hearing with significant reduction in DPOAE amplitudes post the match (P = 0.002 and P = 0.008, respectively). It was therefore concluded that noise levels at well-attended South African PSL matches pose a significant risk to spectators&amp;amp;amp;amp;#39; auditory function as shown by reduced DPOAE amplitude post match attendance. Three risk factors for overexposure to noise during the match were identified: blowing the vuvuzela, close proximity to the individual blowing the vuvuzela as well as spectator turnout at the match.
The South African journal of communication disorders. Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings, Jul 16, 2018
Background: Although distortion product otoacoustic emissions (DPOAEs) are useful in evaluating c... more Background: Although distortion product otoacoustic emissions (DPOAEs) are useful in evaluating cochlear outer hair cell function, determining the optimal stimulus parameters could result in a more reliable, sensitive and specific diagnostic tool across the range of DPOAE applications. Objectives: To identify which stimulus parameters warrant further investigation for eliciting the largest and most reliable DPOAEs in adult humans. Method: A single group, repeated measures design involving a convenience sample of 20 normal-hearing participants between 19 and 24 years of age. Results: Descriptive statistics and mixed model analyses suggested L 1 /L 2 intensity levels of 65/65 dB sound pressure level (SPL) and 65/55 dB SPL, and f 2 /f 1 ratios of 1.18, 1.20 and 1.22 elicited larger and more reliable DPOAEs in both ears. Conclusion: Further investigation of the 65/65 dB SPL and 65/55 dB SPL intensity levels and the 1.18, 1.20 and 1.22 f 2 /f 1 ratios is warranted to determine the stimulus parameters for eliciting the largest and most reliable DPOAEs in adult humans across the range of DPOAE applications.
South African Journal of Communication Disorders
Background: Although distortion product otoacoustic emissions (DPOAEs) are useful in evaluating c... more Background: Although distortion product otoacoustic emissions (DPOAEs) are useful in evaluating cochlear outer hair cell function, determining the optimal stimulus parameters could result in a more reliable, sensitive and specific diagnostic tool across the range of DPOAE applications. Objectives: To identify which stimulus parameters warrant further investigation for eliciting the largest and most reliable DPOAEs in adult humans. Method: A single group, repeated measures design involving a convenience sample of 20 normal-hearing participants between 19 and 24 years of age. Results: Descriptive statistics and mixed model analyses suggested L1/L2 intensity levels of 65/65 dB sound pressure level (SPL) and 65/55 dB SPL, and f2/f1 ratios of 1.18, 1.20 and 1.22 elicited larger and more reliable DPOAEs in both ears. Conclusion: Further investigation of the 65/65 dB SPL and 65/55 dB SPL intensity levels and the 1.18, 1.20 and 1.22 f2/f1 ratios is warranted to determine the stimulus parame...
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2009
South Africa is currently experiencing a TB epidemic with an estimated incidence of 940 / 100 000... more South Africa is currently experiencing a TB epidemic with an estimated incidence of 940 / 100 000 population / year, and the country has been ranked 4th among the 22 high-burden TB countries worldwide by the World Health Organization (WHO). A potentially devastating threat to TB control is the emergence of multidrug-resistant TB (MDR-TB) and, more recently, extensively drug-resistant TB (XDR-TB), mainly as a result of poor drug adherence by TB patients and incorrect management or treatment regimens by health providers ; however, direct transmission of drug-resistant strains also plays an important role. The MDR / XDR-TB strains necessitate prolonged chemotherapy for up to 2 years or more, and the use of more toxic second-line drugs including the aminoglycoside (streptomycin, kanamycin and amikacin) and polypeptide (capreomycin) antibiotics. In South Africa, in accordance with WHO guidelines, streptomycin is used for retreatment of TB while kanamycin, amikacin and capreomycin are use...
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Books by Lucretia Petersen
Papers by Lucretia Petersen