Surgical removal of the spleen, splenectomy, is a procedure that has significantly decreased in f... more Surgical removal of the spleen, splenectomy, is a procedure that has significantly decreased in frequency as our understanding of the infectious complications of the asplenic state increased. The full spectrum and details of splenic function, however, have yet to be fully outlined. As a result, our comprehension of the long-term consequences of splenectomy remains incomplete. We review the evidence relating to the effects of splenectomy on infection, malignancy, thrombosis, and transplantation. Perhaps the best-defined and most widely understood complication of splenectomy is the asplenic patient's susceptibility to infection. In response to this concern, novel techniques have emerged to attempt to preserve splenic function in those patients for whom surgical therapy of the spleen is necessary. The efficacy of these techniques in preserving splenic function and staving off the complications associated with splenectomy is also reviewed in this article.
Fetal antigens are allogeneic to the mother's immune system and should theoretically elicit an im... more Fetal antigens are allogeneic to the mother's immune system and should theoretically elicit an immune response. The fact that this does not occur and that the fetus thrives for so long in the mother without undergoing rejection by her immune system is a scientific mystery. There are five main theories that could explain the fetus's success in evading the mother's immune system. These are the mother's overall immune suppressed state, maternal tolerance to fetal antigens, down-regulation of fetal antigens, the presence of a barrier between maternal immunity and the fetus, and local immune suppression at the site of the placenta. None of these mechanisms can fully explain this phenomenon despite the varying degrees of evidence in support of each. The last mechanism (local immune suppression) seems to be the most plausible one according to current thinking. The actual explanation of this paradox may well lie in a combination of several different factors rather than a single account. K Ke ey y w wo or rd ds s: : immune system, fetus, pregnancy.
Surgical removal of the spleen, splenectomy, is a procedure that has significantly decreased in f... more Surgical removal of the spleen, splenectomy, is a procedure that has significantly decreased in frequency as our understanding of the infectious complications of the asplenic state increased. The full spectrum and details of splenic function, however, have yet to be fully outlined. As a result, our comprehension of the long-term consequences of splenectomy remains incomplete. We review the evidence relating to the effects of splenectomy on infection, malignancy, thrombosis, and transplantation. Perhaps the best-defined and most widely understood complication of splenectomy is the asplenic patient's susceptibility to infection. In response to this concern, novel techniques have emerged to attempt to preserve splenic function in those patients for whom surgical therapy of the spleen is necessary. The efficacy of these techniques in preserving splenic function and staving off the complications associated with splenectomy is also reviewed in this article.
Surgical removal of the spleen, splenectomy, is a procedure that has significantly decreased in f... more Surgical removal of the spleen, splenectomy, is a procedure that has significantly decreased in frequency as our understanding of the infectious complications of the asplenic state increased. The full spectrum and details of splenic function, however, have yet to be fully outlined. As a result, our comprehension of the long-term consequences of splenectomy remains incomplete. We review the evidence relating to the effects of splenectomy on infection, malignancy, thrombosis, and transplantation. Perhaps the best-defined and most widely understood complication of splenectomy is the asplenic patient's susceptibility to infection. In response to this concern, novel techniques have emerged to attempt to preserve splenic function in those patients for whom surgical therapy of the spleen is necessary. The efficacy of these techniques in preserving splenic function and staving off the complications associated with splenectomy is also reviewed in this article.
Fetal antigens are allogeneic to the mother's immune system and should theoretically elicit an im... more Fetal antigens are allogeneic to the mother's immune system and should theoretically elicit an immune response. The fact that this does not occur and that the fetus thrives for so long in the mother without undergoing rejection by her immune system is a scientific mystery. There are five main theories that could explain the fetus's success in evading the mother's immune system. These are the mother's overall immune suppressed state, maternal tolerance to fetal antigens, down-regulation of fetal antigens, the presence of a barrier between maternal immunity and the fetus, and local immune suppression at the site of the placenta. None of these mechanisms can fully explain this phenomenon despite the varying degrees of evidence in support of each. The last mechanism (local immune suppression) seems to be the most plausible one according to current thinking. The actual explanation of this paradox may well lie in a combination of several different factors rather than a single account. K Ke ey y w wo or rd ds s: : immune system, fetus, pregnancy.
Surgical removal of the spleen, splenectomy, is a procedure that has significantly decreased in f... more Surgical removal of the spleen, splenectomy, is a procedure that has significantly decreased in frequency as our understanding of the infectious complications of the asplenic state increased. The full spectrum and details of splenic function, however, have yet to be fully outlined. As a result, our comprehension of the long-term consequences of splenectomy remains incomplete. We review the evidence relating to the effects of splenectomy on infection, malignancy, thrombosis, and transplantation. Perhaps the best-defined and most widely understood complication of splenectomy is the asplenic patient's susceptibility to infection. In response to this concern, novel techniques have emerged to attempt to preserve splenic function in those patients for whom surgical therapy of the spleen is necessary. The efficacy of these techniques in preserving splenic function and staving off the complications associated with splenectomy is also reviewed in this article.
Uploads
Papers by Ali Cadili