Con el objetivo de determinar el nivel de distribución e incidencia de la rhizoctoniasis de la pa... more Con el objetivo de determinar el nivel de distribución e incidencia de la rhizoctoniasis de la papa (Rhizoctonia solani) en el estado Mérida, y buscar alternativas de manejo, se realizó un diagnóstico de campo en cinco municipios paperos y un estudio en la semilla informal ubicado en los silos de Pico El Águila proveniente de siete municipios productores; posteriormente se evaluaron bajo condiciones de invernaderos y campo alternativas de control con opción a ser incorporadas dentro de un programa de manejo de la enfermedad. En invernadero se evaluó el efecto sobre la enfermedad de los fungicidas Carboxin + Thiram, Mancozeb y Pencycuron (dosis media comercial) y dos biopreparados a base de aislamientos nativos de Trichoderma harzianum (200 g del producto a concentración de 2 x 1011 UFC /200 L de agua) sobre semilla y suelo contaminado, bajo un diseño en bloques al azar de arreglo en factorial, con tres repeticiones. Mientras que en el campo experimental Mucuchíes (3100 msnm) se eval...
La marchitez bacteriana de la papa ocasionada por Ralstonia solanacearum, anteriormente conocida ... more La marchitez bacteriana de la papa ocasionada por Ralstonia solanacearum, anteriormente conocida como Burkholderia solanacearum o Pseudomonas solanacearum E. F Smith, es una de las principales limitantes en la producción de este cultivo en el país, ...
Background. Complement dysregulation occurs in thrombotic microangiopathies (TMAs) other than pri... more Background. Complement dysregulation occurs in thrombotic microangiopathies (TMAs) other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients have been reported previously to be successfully treated with eculizumab. Methods. We identified 29 patients with so-called secondary aHUS who had received eculizumab at 11 Spanish nephrology centres. Primary outcome was TMA resolution, defined by a normalization of platelet count (>150 Â 10 9 /L) and haemoglobin, disappearance of all the markers of microangiopathic haemolytic anaemia (MAHA), and improvement of renal function, with a !25% reduction of serum creatinine from the onset of eculizumab administration. Results. Twenty-nine patients with secondary aHUS (15 druginduced, 8 associated with systemic diseases, 2 with postpartum, 2 with cancer-related, 1 associated with acute humoral rejection and 1 with intestinal lymphangiectasia) were included in this study. The reason to initiate eculizumab treatment was worsening of renal function and persistence of TMA despite treatment of the TMA cause and plasmapheresis. All patients showed severe MAHA and renal function impairment (14 requiring dialysis) prior to eculizumab treatment and 11 presented severe extrarenal manifestations. A rapid resolution of the TMA was observed in 20 patients (68%), 15 of them showing a !50% serum creatinine reduction at the last follow-up. Comprehensive genetic and molecular studies in 22 patients identified complement pathogenic variants in only 2 patients. With these two
Con el objetivo de determinar el nivel de distribución e incidencia de la rhizoctoniasis de la pa... more Con el objetivo de determinar el nivel de distribución e incidencia de la rhizoctoniasis de la papa (Rhizoctonia solani) en el estado Mérida, y buscar alternativas de manejo, se realizó un diagnóstico de campo en cinco municipios paperos y un estudio en la semilla informal ubicado en los silos de Pico El Águila proveniente de siete municipios productores; posteriormente se evaluaron bajo condiciones de invernaderos y campo alternativas de control con opción a ser incorporadas dentro de un programa de manejo de la enfermedad. En invernadero se evaluó el efecto sobre la enfermedad de los fungicidas Carboxin + Thiram, Mancozeb y Pencycuron (dosis media comercial) y dos biopreparados a base de aislamientos nativos de Trichoderma harzianum (200 g del producto a concentración de 2 x 1011 UFC /200 L de agua) sobre semilla y suelo contaminado, bajo un diseño en bloques al azar de arreglo en factorial, con tres repeticiones. Mientras que en el campo experimental Mucuchíes (3100 msnm) se eval...
La marchitez bacteriana de la papa ocasionada por Ralstonia solanacearum, anteriormente conocida ... more La marchitez bacteriana de la papa ocasionada por Ralstonia solanacearum, anteriormente conocida como Burkholderia solanacearum o Pseudomonas solanacearum E. F Smith, es una de las principales limitantes en la producción de este cultivo en el país, ...
Background. Complement dysregulation occurs in thrombotic microangiopathies (TMAs) other than pri... more Background. Complement dysregulation occurs in thrombotic microangiopathies (TMAs) other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients have been reported previously to be successfully treated with eculizumab. Methods. We identified 29 patients with so-called secondary aHUS who had received eculizumab at 11 Spanish nephrology centres. Primary outcome was TMA resolution, defined by a normalization of platelet count (>150 Â 10 9 /L) and haemoglobin, disappearance of all the markers of microangiopathic haemolytic anaemia (MAHA), and improvement of renal function, with a !25% reduction of serum creatinine from the onset of eculizumab administration. Results. Twenty-nine patients with secondary aHUS (15 druginduced, 8 associated with systemic diseases, 2 with postpartum, 2 with cancer-related, 1 associated with acute humoral rejection and 1 with intestinal lymphangiectasia) were included in this study. The reason to initiate eculizumab treatment was worsening of renal function and persistence of TMA despite treatment of the TMA cause and plasmapheresis. All patients showed severe MAHA and renal function impairment (14 requiring dialysis) prior to eculizumab treatment and 11 presented severe extrarenal manifestations. A rapid resolution of the TMA was observed in 20 patients (68%), 15 of them showing a !50% serum creatinine reduction at the last follow-up. Comprehensive genetic and molecular studies in 22 patients identified complement pathogenic variants in only 2 patients. With these two
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