A 17-year old male presented with a breast lump . Gross and Microscopic images from the excised lump ( shown in the images). Identify the true statement? (Options in the comments) #pathology #PathTwitter #PathTwitterFamily #pathtweetorial #tweetorial #MedTwitter #pathboards 
Options:
Diagnosis is juvenile papilomatosis.
Observe "swiss-cheese appearance" in gross and microscopy.
Other conditions with Swiss cheese appearance
Observe "swiss-cheese appearance" in gross and microscopy.
Other conditions with Swiss cheese appearance
Juvenile papillomatosis is associated with Noonan syndrome and neurofibromatosis type 1.
Which molecular pathway is common between these two conditions?
Which molecular pathway is common between these two conditions?
Both Noonan syndrome and Neurofibromatosis type 1 are RAS-opathies. Disorders affecting the RAS/MAPK pathway.
Some other RAS-opathies are in the image.
Some other RAS-opathies are in the image.
Juvenile papilomatosis can transform into breast carcinoma in about 10-20 % cases.
Which subtype of breast carcinoma do you think is common in Juvenile papilomatosis?
Which subtype of breast carcinoma do you think is common in Juvenile papilomatosis?
Secretory breast carcinoma are common to arise in individuals with juvenile papilomatosis.
Secretory breast carcinomas harbour ETV6-NTRK3 fusion- Pin about secretory caacinoma. pin.it/1H92KrA
Other conditions with ETV6-NTRK3 fusion 📌- pin.it/1nfNkQn
Secretory breast carcinomas harbour ETV6-NTRK3 fusion- Pin about secretory caacinoma. pin.it/1H92KrA
Other conditions with ETV6-NTRK3 fusion 📌- pin.it/1nfNkQn
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