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May 20 • 7 tweets • 14 min read
Tracking #BA4 and #BA5 #Omicron #Sublineages over time

This tracker includes only sequences with signature mutations👇

Tracker: public.tableau.com/app/profile/ra…

Updated 5/20/2022
Tracking #BA4/#BA4 in #Asia and #Oceania

Hotspots: #Israel, #Hongkong, #NewSouthWales (#Australia), #Singapore
Emerging Hotspots: #India ImageImage
Tracking #BA4/#BA5 in #Europe

Hotspots: #UnitedKingdom, #Portugal, #Germany, #Denmark, #Belgium, #Italy, #Netherlands, #Austria, #Spain, #France ImageImageImage
Tracking the rise of #BA4/#BA5 in the #UnitedKingdom ImageImage
Tracking #BA4/#BA5 in the Americas

Hotspots
BA.4: #California #NewYork, #Virginia, #NewJersey, #Minnesota
BA.5: #Tennessee, #Illinois, #Texas, #NewYork, #NorthCarolina ImageImageImage
Tracking #BA4/#BA5 in #Africa ImageImage
#CoronaVirusUpdates #BA5

First confirmed case of BA.5 subvariant from #MexicoCity, #Mexico

Sample collection date: 05-07-2022

Global tracker: public.tableau.com/app/profile/ra… Image

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More from @RajlabN

Raj Rajnarayanan Profile picture
May 23
SARSCoV2 BA.2 #subvaraints carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity

Top #NSP5 (MPro) mutations: H164N, G15S, T135I

Should investigate if these NSP5 mutations are also associated with Paxlovid rebound.

1/n Image
Mpro mutations associated with reduced nirmatrelvir activity (≥3-fold higher Ki values): G15S (4.4-fold), T135I (3.5-fold), S144A (91.9-fold), H164N (6.4-fold),
H172Y (233-fold), Q189K (65.4-fold), and D248E (3.7-fold).

fda.gov/media/155050/d…

2/n
Omicron-MPro-Pax-Tracker: (by sublineage, by state/division, by county/location):

3/n
 public.tableau.com/app/profile/ra…
Read 4 tweets
Raj Rajnarayanan Profile picture
May 23
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

38.23% BA.2,
35.84% BA.2.12.1**,
8.82% BA.2.12,
5.85% BA.2.3,
4.03% BA.2.9,
1.55% BA.5/BA.4^^

** S:L452Q;
^^ S:L452R/F486V

Tracker (by location): tinyurl.com/mryj4uu7
#OmicronUpdates 05/22/22 Image
#OmicronVariantUpdates #UnitedStates 05/22/22

Top circulating lineages: BA.2*, BA.2.12.1, BA.2.12#, BA.2.3, BA.2.9, BA.5 and BA.4

Proportion of BA.5/BA.4 is increasing

* includes recently designated BA.2.x.y
# potential misassignments Image
BA.2.12 and BA.2.12.1 hotspots (#15DayTrends) ImageImage
Read 5 tweets
Raj Rajnarayanan Profile picture
May 22
Tracking #BA4 and #BA5 #Omicron #Sublineages over time

This tracker includes only sequences with signature mutations👇

Tracker: public.tableau.com/app/profile/ra…

Updated 5/22/2022
Tracking #BA4/#BA4 in #Asia and #Oceania

Hotspots: #Israel, #Hongkong, #NewSouthWales (#Australia), #Singapore
Emerging Hotspots: #India
#NewZealand (MIQ facility) ImageImage
Tracking #BA4/#BA5 in #Europe

Hotspots
BA.4: #UnitedKingdom, #Denmark, #Germany, #Belgium, #Italy, #Netherlands
BA.5: #Germany, #Portugal, #UnitedKingdom, #Austria, #Spain, #France ImageImageImage
Read 6 tweets
Raj Rajnarayanan Profile picture
May 21
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

38.18% BA.2,
35.67% BA.2.12.1**,
7.95% BA.2.12,
6.35% BA.2.3,
4.22% BA.2.9,
0.79% BA.5 and
0.68% BA.2.18

** S:L452Q

Tracker (by location): tinyurl.com/mryj4uu7
#OmicronUpdates 05/21/22 Image
#OmicronVariantUpdates #UnitedStates 05/21/22

Top 10 circulating lineages: BA.2*, BA.2.12.1, BA.2.12#, BA.2.3, BA.2.9, BA.5, BA.2.18, BA.2.10, BA.2.23, BA.2.7 and BA.4

* includes recently designated BA.2.x.y
# potential misassignments Image
BA.2.12 and BA.2.12.1 hotspots ImageImage
Read 5 tweets
Raj Rajnarayanan Profile picture
May 21
Tracking #BA4 and #BA5 #Omicron #Sublineages over time

This tracker includes only sequences with signature mutations👇

Tracker: public.tableau.com/app/profile/ra…

Updated 5/21/2022
Tracking #BA4/#BA4 in #Asia and #Oceania

Hotspots: #Israel, #Hongkong, #NewSouthWales (#Australia), #Singapore
Emerging Hotspots: #India
#NewZealand (MIQ facility) ImageImage
Tracking #BA4/#BA5 in #Europe

Hotspots: #UnitedKingdom, #Portugal, #Germany, #Denmark, #Belgium, #Italy, #Netherlands, #Austria, #Spain, #France ImageImageImage
Read 7 tweets
Raj Rajnarayanan Profile picture
May 20
#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

37.66% BA.2,
37.16% BA.2.12.1**,
6.76% BA.2.12,
6.41% BA.2.3,
4.96% BA.2.9,
0.85% BA.2.7 &
0.70% BA.5

** S:L452Q

Tracker (by location): tinyurl.com/mryj4uu7
#OmicronUpdates 05/20/22 Image
#OmicronVariantUpdates #UnitedStates 05/20/22

Top 10 circulating lineages: BA.2*, BA.2.12.1, BA.2.12#, BA.2.3, BA.2.9, BA.2.7, BA.5, BA.2.10, BA.2.18, BA.2.23 and BA.4

* includes recently designated BA.2.x.y
# potential misassignments Image
BA.2.12 and BA.2.12.1 hotspots ImageImage
Read 5 tweets

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