Ethanol inhibits the synaptosomal transport of some putative neurotransmitters in rat brain homog... more Ethanol inhibits the synaptosomal transport of some putative neurotransmitters in rat brain homogenates. The uptake of {3H)DL-norepinephrine, { 3H)5-hydroxytryptamine and {3H)GARA is inhibited only 30 to 40% at an ethanol concentration of 30 mg/ml. {3H)Glutamate transport, however, is decreased by about 80% at the same ethanol concentration. Aliphatic alcohols of increasing hydrophobic character cause a progressively greater decrease in transmitter transport, suggesting that the inhibitory effect is due to an interaction of the alcohol with the lipid portion of the synaptosomal membrane .
Hyperphenylalaninemia was induced in neonatal rats by p-chlorophenylalanine and phenylalanine tre... more Hyperphenylalaninemia was induced in neonatal rats by p-chlorophenylalanine and phenylalanine treatment up to 21 days of age. Brain and body weights of the hyperphenylalaninemic rats were significantly reduced when compared to controls. Amino acid compartmentation, demonstrated by the ratio of specific radioactivity of glatamine to glutamate after the administration of L-[U-14C]leucine, developed more slowly in the hyperphenylalaninemic group. This result is similar to that seen with thyroidectomized neonatal rats and suggests an inhibition to neuronal process growth. Though the brain levels of amino acids derived through the TCA cycle increased during development, glutamate and glutamine concentrations were significantly less in the hyperphenylalaninemic group than the controls. Body weight and amino acid compartmentation returned to normal 3 weeks after termination of drug treatment whereas brain weight and glutamate and glutamine concentrations did not return to normal.
Hyperphenylalaninemia was induced in neonatal rats by p-chlorophenylalanine and phenylalanine tre... more Hyperphenylalaninemia was induced in neonatal rats by p-chlorophenylalanine and phenylalanine treatment up to 21 days of age. Brain and body weights of the hyperphenylalaninemic rats were significantly reduced when compared to controls. Amino acid compartmentation, demonstrated by the ratio of specific radioactivity of glatamine to glutamate after the administration of L-[U-14C]leucine, developed more slowly in the hyperphenylalaninemic group. This result is similar to that seen with thyroidectomized neonatal rats and suggests an inhibition to neuronal process growth. Though the brain levels of amino acids derived through the TCA cycle increased during development, glutamate and glutamine concentrations were significantly less in the hyperphenylalaninemic group than the controls. Body weight and amino acid compartmentation returned to normal 3 weeks after termination of drug treatment whereas brain weight and glutamate and glutamine concentrations did not return to normal.
Ethanol inhibits the synaptosomal transport of some putative neurotransmitters in rat brain homog... more Ethanol inhibits the synaptosomal transport of some putative neurotransmitters in rat brain homogenates. The uptake of {3H)DL-norepinephrine, { 3H)5-hydroxytryptamine and {3H)GARA is inhibited only 30 to 40% at an ethanol concentration of 30 mg/ml. {3H)Glutamate transport, however, is decreased by about 80% at the same ethanol concentration. Aliphatic alcohols of increasing hydrophobic character cause a progressively greater decrease in transmitter transport, suggesting that the inhibitory effect is due to an interaction of the alcohol with the lipid portion of the synaptosomal membrane .
Hyperphenylalaninemia was induced in neonatal rats by p-chlorophenylalanine and phenylalanine tre... more Hyperphenylalaninemia was induced in neonatal rats by p-chlorophenylalanine and phenylalanine treatment up to 21 days of age. Brain and body weights of the hyperphenylalaninemic rats were significantly reduced when compared to controls. Amino acid compartmentation, demonstrated by the ratio of specific radioactivity of glatamine to glutamate after the administration of L-[U-14C]leucine, developed more slowly in the hyperphenylalaninemic group. This result is similar to that seen with thyroidectomized neonatal rats and suggests an inhibition to neuronal process growth. Though the brain levels of amino acids derived through the TCA cycle increased during development, glutamate and glutamine concentrations were significantly less in the hyperphenylalaninemic group than the controls. Body weight and amino acid compartmentation returned to normal 3 weeks after termination of drug treatment whereas brain weight and glutamate and glutamine concentrations did not return to normal.
Hyperphenylalaninemia was induced in neonatal rats by p-chlorophenylalanine and phenylalanine tre... more Hyperphenylalaninemia was induced in neonatal rats by p-chlorophenylalanine and phenylalanine treatment up to 21 days of age. Brain and body weights of the hyperphenylalaninemic rats were significantly reduced when compared to controls. Amino acid compartmentation, demonstrated by the ratio of specific radioactivity of glatamine to glutamate after the administration of L-[U-14C]leucine, developed more slowly in the hyperphenylalaninemic group. This result is similar to that seen with thyroidectomized neonatal rats and suggests an inhibition to neuronal process growth. Though the brain levels of amino acids derived through the TCA cycle increased during development, glutamate and glutamine concentrations were significantly less in the hyperphenylalaninemic group than the controls. Body weight and amino acid compartmentation returned to normal 3 weeks after termination of drug treatment whereas brain weight and glutamate and glutamine concentrations did not return to normal.
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