>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = {1:1, 2:"2", 3:3}
>>> print(DeepDiff(t1, t2))
{'type_changes': ["root[2]: 2=<type 'int'> ===> 2=<type 'str'>"]}

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = {1:1, 2:4, 3:3}
>>> print(DeepDiff(t1, t2))
{'values_changed': ['root[2]: 2 ===> 4']}

>>> t1 = {1:1, 2:2, 3:3, 4:4}
>>> t2 = {1:1, 2:4, 3:3, 5:5, 6:6}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff)
{'dic_item_added': ['root[5, 6]'],
 'dic_item_removed': ['root[4]'],
 'values_changed': ['root[2]: 2 ===> 4']}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world"}}
>>> t2 = {1:1, 2:4, 3:3, 4:{"a":"hello", "b":"world!"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'values_changed': [ 'root[2]: 2 ===> 4',
                      "root[4]['b']: 'world' ===> 'world!'"]}
>>>
>>> print (ddiff['values_changed'][1])
root[4]['b']: 'world' ===> 'world!'

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world!\nGoodbye!\n1\n2\nEnd"}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world\n1\n2\nEnd"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'values_changed': [ "root[4]['b']:\n"
                      '--- \n'
                      '+++ \n'
                      '@@ -1,5 +1,4 @@\n'
                      '-world!\n'
                      '-Goodbye!\n'
                      '+world\n'
                      ' 1\n'
                      ' 2\n'
                      ' End']}
>>>
>>> print (ddiff['values_changed'][0])
root[4]['b']:
--- 
+++ 
@@ -1,5 +1,4 @@
-world!
-Goodbye!
+world
 1
 2
 End

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world\n\n\nEnd"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'type_changes': [ "root[4]['b']: [1, 2, 3]=<type 'list'> ===> world\n"
                    '\n'
                    '\n'
                    "End=<type 'str'>"]}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3, 4]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{'iterable_item_removed': ["root[4]['b']: [3, 4]"]}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 3, 2, 3]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'iterable_item_added': ["root[4]['b']: [3]"],
  'values_changed': ["root[4]['b'][1]: 2 ===> 3", "root[4]['b'][2]: 3 ===> 2"]}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, {1:1, 2:2}]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, {1:3}]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'dic_item_removed': ["root[4]['b'][2][2]"],
  'values_changed': ["root[4]['b'][2][1]: 1 ===> 3"]}

>>> t1 = {1, 2, 8}
>>> t2 = {1, 2, 3, 5}
>>> ddiff = DeepDiff(t1, t2)
>>> print (DeepDiff(t1, t2))
{'set_item_added': ['root: [3, 5]'], 'set_item_removed': ['root: [8]']}

>>> from collections import namedtuple
>>> Point = namedtuple('Point', ['x', 'y'])
>>> t1 = Point(x=11, y=22)
>>> t2 = Point(x=11, y=23)
>>> print (DeepDiff(t1, t2))
{'values_changed': ['root.y: 22 ===> 23']}

>>> class ClassA(object):
...     a = 1
...     def __init__(self, b):
...         self.b = b
...
>>> t1 = ClassA(1)
>>> t2 = ClassA(2)
>>>
>>> print(DeepDiff(t1, t2))
{'values_changed': ['root.b: 1 ===> 2']}

>>> t2.c = "new attribute"
>>> print(DeepDiff(t1, t2))
{'attribute_added': ['root.c'], 'values_changed': ['root.b: 1 ===> 2']}

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = {1:1, 2:"2", 3:3}
>>> pprint(DeepDiff(t1, t2), indent=2)
{ 'type_changes': { 'root[2]': { 'newtype': <class 'str'>,
                                 'newvalue': '2',
                                 'oldtype': <class 'int'>,
                                 'oldvalue': 2}}}

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = {1:1, 2:4, 3:3}
>>> pprint(DeepDiff(t1, t2), indent=2)
{'values_changed': {'root[2]': {'newvalue': 4, 'oldvalue': 2}}}

>>> t1 = {1:1, 2:2, 3:3, 4:4}
>>> t2 = {1:1, 2:4, 3:3, 5:5, 6:6}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff)
{'dic_item_added': ['root[5]', 'root[6]'],
 'dic_item_removed': ['root[4]'],
 'values_changed': {'root[2]': {'newvalue': 4, 'oldvalue': 2}}}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world"}}
>>> t2 = {1:1, 2:4, 3:3, 4:{"a":"hello", "b":"world!"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'values_changed': { 'root[2]': {'newvalue': 4, 'oldvalue': 2},
                      "root[4]['b']": { 'newvalue': 'world!',
                                        'oldvalue': 'world'}}}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world!\nGoodbye!\n1\n2\nEnd"}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world\n1\n2\nEnd"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'values_changed': { "root[4]['b']": { 'diff': '--- \n'
                                                '+++ \n'
                                                '@@ -1,5 +1,4 @@\n'
                                                '-world!\n'
                                                '-Goodbye!\n'
                                                '+world\n'
                                                ' 1\n'
                                                ' 2\n'
                                                ' End',
                                        'newvalue': 'world\n1\n2\nEnd',
                                        'oldvalue': 'world!\n'
                                                    'Goodbye!\n'
                                                    '1\n'
                                                    '2\n'
                                                    'End'}}} 

>>> 
>>> print (ddiff['values_changed']["root[4]['b']"]["diff"])
--- 
+++ 
@@ -1,5 +1,4 @@
-world!
-Goodbye!
+world
 1
 2
 End

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world\n\n\nEnd"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'type_changes': { "root[4]['b']": { 'newtype': <class 'str'>, 
                                      'newvalue': 'world\n\n\nEnd',
                                      'oldtype': <class 'list'>,
                                      'oldvalue': [1, 2, 3]}}}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3, 4]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{'iterable_item_removed': {"root[4]['b'][2]": 3, "root[4]['b'][3]": 4}}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 3, 2, 3]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'iterable_item_added': {"root[4]['b'][3]": 3},
  'values_changed': { "root[4]['b'][1]": {'newvalue': 3, 'oldvalue': 2}, 
                      "root[4]['b'][2]": {'newvalue': 2, 'oldvalue': 3}}}

List difference ignoring order or duplicates: (with the same dictionaries as above)

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 3, 2, 3]}}
>>> ddiff = DeepDiff(t1, t2, ignore_order=True)
>>> print (ddiff)
{}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, {1:1, 2:2}]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, {1:3}]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'dic_item_removed': ["root[4]['b'][2][2]"],
  'values_changed': {"root[4]['b'][2][1]": {'newvalue': 3, 'oldvalue': 1}}}

>>> t1 = {1, 2, 8}
>>> t2 = {1, 2, 3, 5}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (DeepDiff(t1, t2))
{'set_item_added': ['root[3]', 'root[5]'], 'set_item_removed': ['root[8]']}

>>> from collections import namedtuple
>>> Point = namedtuple('Point', ['x', 'y'])
>>> t1 = Point(x=11, y=22)
>>> t2 = Point(x=11, y=23)
>>> pprint (DeepDiff(t1, t2))
{'values_changed': {'root.y': {'newvalue': 23, 'oldvalue': 22}}}

>>> class ClassA(object):
...     a = 1
...     def __init__(self, b):
...         self.b = b
... 
>>> t1 = ClassA(1)
>>> t2 = ClassA(2)
>>> 
>>> pprint(DeepDiff(t1, t2))
{'values_changed': {'root.b': {'newvalue': 2, 'oldvalue': 1}}}

>>> t2.c = "new attribute"
>>> pprint(DeepDiff(t1, t2))
{'attribute_added': ['root.c'], 
 'values_changed': {'root.b': {'newvalue': 2, 'oldvalue': 1}}}

In case you want the difference recursively in your lists, I have written a package for python 2. I will update it for python 3 later: https://github.com/erasmose/deepdiff

>>> from deepdiff import DeepDiff
>>> from pprint import pprint
>>> from __future__ import print_function

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = t1
>>> ddiff = DeepDiff(t1, t2)
>>> print (ddiff.changes)
    {}

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = {1:1, 2:"2", 3:3}
>>> ddiff = DeepDiff(t1, t2)
>>> print (ddiff.changes)
    {'type_changes': ["root[2]: 2=<type 'int'> vs. 2=<type 'str'>"]}

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = {1:1, 2:4, 3:3}
>>> ddiff = DeepDiff(t1, t2)
>>> print (ddiff.changes)
    {'values_changed': ['root[2]: 2 ====>> 4']}

>>> t1 = {1:1, 2:2, 3:3, 4:4}
>>> t2 = {1:1, 2:4, 3:3, 5:5, 6:6}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff.changes)
    {'dic_item_added': ['root[5, 6]'],
     'dic_item_removed': ['root[4]'],
     'values_changed': ['root[2]: 2 ====>> 4']}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world"}}
>>> t2 = {1:1, 2:4, 3:3, 4:{"a":"hello", "b":"world!"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff.changes, indent = 2)
    { 'values_changed': [ 'root[2]: 2 ====>> 4',
                          "root[4]['b']:\n--- \n+++ \n@@ -1 +1 @@\n-world\n+world!"]}
>>>
>>> print (ddiff.changes['values_changed'][1])
    root[4]['b']:
    --- 
    +++ 
    @@ -1 +1 @@
    -world
    +world!

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world!\nGoodbye!\n1\n2\nEnd"}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world\n1\n2\nEnd"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff.changes, indent = 2)
    { 'values_changed': [ "root[4]['b']:\n--- \n+++ \n@@ -1,5 +1,4 @@\n-world!\n-Goodbye!\n+world\n 1\n 2\n End"]}
>>>
>>> print (ddiff.changes['values_changed'][0])
    root[4]['b']:
    --- 
    +++ 
    @@ -1,5 +1,4 @@
    -world!
    -Goodbye!
    +world
     1
     2
     End

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world\n\n\nEnd"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff.changes, indent = 2)
    { 'type_changes': [ "root[4]['b']: [1, 2, 3]=<type 'list'> vs. world\n\n\nEnd=<type 'str'>"]}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff.changes, indent = 2)
    { 'list_removed': ["root[4]['b']: [3]"]}

List difference 2: Note that it DOES NOT take order into account

>>> # Note that it DOES NOT take order into account
... t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 3, 2]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff.changes, indent = 2)
    { }

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, {1:1, 2:2}]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, {1:3}]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff.changes, indent = 2)
    { 'dic_item_removed': ["root[4]['b'][2][2]"],
      'values_changed': ["root[4]['b'][2][1]: 1 ====>> 3"]}

In case you want the difference recursively, I have written a package for python: https://github.com/seperman/deepdiff

Importing

>>> from deepdiff import DeepDiff
>>> from pprint import pprint
>>> from __future__ import print_function # In case running on Python 2

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = t1
>>> print(DeepDiff(t1, t2))
{}

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = {1:1, 2:"2", 3:3}
>>> print(DeepDiff(t1, t2))
{'type_changes': ["root[2]: 2=<type 'int'> ===> 2=<type 'str'>"]}

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = {1:1, 2:4, 3:3}
>>> print(DeepDiff(t1, t2))
{'values_changed': ['root[2]: 2 ===> 4']}

>>> t1 = {1:1, 2:2, 3:3, 4:4}
>>> t2 = {1:1, 2:4, 3:3, 5:5, 6:6}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff)
{'dic_item_added': ['root[5, 6]'],
 'dic_item_removed': ['root[4]'],
 'values_changed': ['root[2]: 2 ===> 4']}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world"}}
>>> t2 = {1:1, 2:4, 3:3, 4:{"a":"hello", "b":"world!"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'values_changed': [ 'root[2]: 2 ===> 4',
                      "root[4]['b']: 'world' ===> 'world!'"]}
>>>
>>> print (ddiff['values_changed'][1])
root[4]['b']: 'world' ===> 'world!'

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world!\nGoodbye!\n1\n2\nEnd"}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world\n1\n2\nEnd"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'values_changed': [ "root[4]['b']:\n"
                      '--- \n'
                      '+++ \n'
                      '@@ -1,5 +1,4 @@\n'
                      '-world!\n'
                      '-Goodbye!\n'
                      '+world\n'
                      ' 1\n'
                      ' 2\n'
                      ' End']}
>>>
>>> print (ddiff['values_changed'][0])
root[4]['b']:
--- 
+++ 
@@ -1,5 +1,4 @@
-world!
-Goodbye!
+world
 1
 2
 End

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world\n\n\nEnd"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'type_changes': [ "root[4]['b']: [1, 2, 3]=<type 'list'> ===> world\n"
                    '\n'
                    '\n'
                    "End=<type 'str'>"]}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3, 4]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{'iterable_item_removed': ["root[4]['b']: [3, 4]"]}

List difference 2:

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 3, 2, 3]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'iterable_item_added': ["root[4]['b']: [3]"],
  'values_changed': ["root[4]['b'][1]: 2 ===> 3", "root[4]['b'][2]: 3 ===> 2"]}

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, {1:1, 2:2}]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, {1:3}]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'dic_item_removed': ["root[4]['b'][2][2]"],
  'values_changed': ["root[4]['b'][2][1]: 1 ===> 3"]}

Sets:

>>> t1 = {1, 2, 8}
>>> t2 = {1, 2, 3, 5}
>>> ddiff = DeepDiff(t1, t2)
>>> print (DeepDiff(t1, t2))
{'set_item_added': ['root: [3, 5]'], 'set_item_removed': ['root: [8]']}

Named Tuples:

>>> from collections import namedtuple
>>> Point = namedtuple('Point', ['x', 'y'])
>>> t1 = Point(x=11, y=22)
>>> t2 = Point(x=11, y=23)
>>> print (DeepDiff(t1, t2))
{'values_changed': ['root.y: 22 ===> 23']}

Custom objects:

>>> class ClassA(object):
...     a = 1
...     def __init__(self, b):
...         self.b = b
...
>>> t1 = ClassA(1)
>>> t2 = ClassA(2)
>>>
>>> print(DeepDiff(t1, t2))
{'values_changed': ['root.b: 1 ===> 2']}

Object attribute added:

>>> t2.c = "new attribute"
>>> print(DeepDiff(t1, t2))
{'attribute_added': ['root.c'], 'values_changed': ['root.b: 1 ===> 2']}