Tirozin 3-monooksigenaza
(преусмерено са Inhibitor tirozinske hidroksilaze)
| Tirozin 3-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.16.2 | ||||||||
| CAS broj | 9036-22-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Tirozin 3-monooksigenaza (EC 1.14.16.2, L-tirozinska hidroksilaza, tirozinska 3-hidroksilaza, tirozinska hidroksilaza) je enzim sa sistematskim imenom L-tirozin,tetrahidrobiopterin:kiseonik oksidoreduktaza (3-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-tirozin + tetrahidrobiopterin + O2 L-dopa + 4a-hidroksitetrahidrobiopterin
Aktivni centar sadrži mononuklearno gvožđe(II). Ovaj enzim se aktivira fosforilacijom.
Reference
[уреди | уреди извор]- ^ El Mestikawy, S., Glowinski, J. and Hamon, M. (1983). „Tyrosine hydroxylase activation in depolarized dopaminergic terminals -involvement of Ca2+-dependent phosphorylation”. Nature (Lond.). 302: 830—832. PMID 6133218.
- ^ Ikeda, M., Levitt, M. and Udenfriend, S. (1967). „Phenylalanine as substrate and inhibitor of tyrosine hydroxylase”. Arch. Biochem. Biophys. 120: 420—427. PMID 6033458.
- ^ Nagatsu, T., Levitt, M. and Udenfriend, S. (1964). „Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis”. J. Biol. Chem. 239: 2910—2917. PMID 14216443.
- ^ Pigeon, D., Drissi-Daoudi, R., Gros, F. and Thibault, J. (1986). „Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase”. C. R. Acad. Sci. III. 302: 435—438. PMID 2872947.
- ^ Goodwill, K.E., Sabatier, C., Marks, C., Raag, R., Fitzpatrick, P.F. and Stevens, R.C. (1997). „Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases”. Nat. Struct. Biol. 4: 578—585. PMID 9228951.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Tyrosine+3-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
