CCL27

Hemokin (C-C motiv) ligand 27
Hemokin (C-C motiv) ligand 27
Identifikatori
Simbol	CCL27
Alt. simboli	SCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
Entrez	10850
HUGO	10626
OMIM	604833
RefSeq	NM_006664
UniProt	Q9Y4X3
Ostali podaci
Lokus	Hromozom 9 q13

CCL27, hemokin (C-C motiv) ligand 27, je mali citokin iz CC hemokin familije koji je takođe poznat pod imenima IL-11 R-alfa-lokus hemokin (ILC), skinkin, ESkin i kožni T-ćelijski atraktivni hemokin (CTACK). On je asociran sa navođenjem memorijskih T limfocita ka koži, i on učestvuje u T ćelijama posredovanoj inflamaciji kože.^[1]^[2] CCL27 je izražen u brojnim tkivima, među kojima su gonade, timus, posteljica i koža. On ispoljava svoje hemotaksne efekte vezivanjem za hemokinski receptor CCR10.^[3] CCL27 gen je lociran na ljudskom hromozomu 9.^[4]^[5]

Reference

^ Morales; et al. (1999). „CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells”. Proc. Natl. Acad. Sci. U.S.A. 96: 14470—14475.
^ Homey; et al. (2002). „CCL27-CCR10 interactions regulate T cell-mediated skin inflammation”. Nature Med. 8: 157—165.
^ Homey; et al. (2000). „The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)”. J. Immunol. 164: 3465—3470.
^ Ishikawa-Mochizuki; et al. (1999). „Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus”. FEBS Lett. 460: 544—548.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

Literatura

Spoljašnje veze

CCL27 GeneCard

[1] Morales; et al. (1999). „CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells”. Proc. Natl. Acad. Sci. U.S.A. 96: 14470—14475.

[2] Homey; et al. (2002). „CCL27-CCR10 interactions regulate T cell-mediated skin inflammation”. Nature Med. 8: 157—165.

[3] Homey; et al. (2000). „The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)”. J. Immunol. 164: 3465—3470.

[4] Ishikawa-Mochizuki; et al. (1999). „Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus”. FEBS Lett. 460: 544—548.

[5] Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

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