NAD(P)H oksidaza

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PubMed	članci
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NAD(P)H oksidaza
NAD(P)H oksidaza
Identifikatori
EC broj	1.6.3.1
CAS broj	77106-92-4
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

NAD(P)H oksidaza (EC 1.6.3.1, THOX2, ThOX, dualna oksidaza, p138tox, tiroid NADPH oksidaza, tiroidna oksidaza, tiroidna oksidaza 2, NADPH oksidaza) je enzim sa sistematskim imenom NAD(P)H:kiseonik oksidoreduktaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

NAD(P)H + H⁺ + O₂

\rightleftharpoons

NAD(P)⁺ +H₂O₂

Za rad ovog enzima je neophodan FAD, hem i kalcijum.

Reference

^ Moreno, J.C., Bikker, H., Kempers, M.J., van Trotsenburg, A.S., Baas, F., de Vijlder, J.J., Vulsma, T. and Ris-Stalpers, C. (2002). „Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism”. N. Engl. J. Med. 347: 95—102. PMID 12110737.
^ De Deken, X., Wang, D., Dumont, J.E. and Miot, F. (2002). „Characterization of ThOX proteins as components of the thyroid H₂O₂-generating system”. Exp. Cell. 273: 187—196. PMID 11822874.
^ De Deken, X., Wang, D., Many, M.C., Costagliola, S., Libert, F., Vassart, G., Dumont, J.E. and Miot, F. (2000). „Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family”. J. Biol. Chem. 275: 23227—23233. PMID 10806195.
^ Dupuy, C., Ohayon, R., Valent, A., Noel-Hudson, M.S., Deme, D. and Virion, A. (1999). „Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs”. J. Biol. Chem. 274: 37265—37269. PMID 10601291.
^ Leseney, A.M., Deme, D., Legue, O., Ohayon, R., Chanson, P., Sales, J.P., Pires de Carvalho, D., Dupuy, C. and Virion, A. (1999). „Biochemical characterization of a Ca²⁺/NAD(P)H-dependent H₂O₂ generator in human thyroid tissue”. Biochimie. 81: 373—380. PMID 10401672.
^ Dupuy, C., Virion, A., Ohayon, R., Kaniewski, J., Deme, D. and Pommier, J. (1991). „Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane”. J. Biol. Chem. 266: 3739—3743. PMID 1995628.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

NAD(P)H+oxidase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Moreno, J.C., Bikker, H., Kempers, M.J., van Trotsenburg, A.S., Baas, F., de Vijlder, J.J., Vulsma, T. and Ris-Stalpers, C. (2002). „Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism”. N. Engl. J. Med. 347: 95—102. PMID 12110737.

[2] De Deken, X., Wang, D., Dumont, J.E. and Miot, F. (2002). „Characterization of ThOX proteins as components of the thyroid H₂O₂-generating system”. Exp. Cell. 273: 187—196. PMID 11822874.

[3] De Deken, X., Wang, D., Many, M.C., Costagliola, S., Libert, F., Vassart, G., Dumont, J.E. and Miot, F. (2000). „Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family”. J. Biol. Chem. 275: 23227—23233. PMID 10806195.

[4] Dupuy, C., Ohayon, R., Valent, A., Noel-Hudson, M.S., Deme, D. and Virion, A. (1999). „Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs”. J. Biol. Chem. 274: 37265—37269. PMID 10601291.

[5] Leseney, A.M., Deme, D., Legue, O., Ohayon, R., Chanson, P., Sales, J.P., Pires de Carvalho, D., Dupuy, C. and Virion, A. (1999). „Biochemical characterization of a Ca²⁺/NAD(P)H-dependent H₂O₂ generator in human thyroid tissue”. Biochimie. 81: 373—380. PMID 10401672.

[6] Dupuy, C., Virion, A., Ohayon, R., Kaniewski, J., Deme, D. and Pommier, J. (1991). „Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane”. J. Biol. Chem. 266: 3739—3743. PMID 1995628.

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