Conference Presentations by Mo'men A . Salem
Alzheimer's disease is a degenerative brain syndrome that affects more than 37 million people wor... more Alzheimer's disease is a degenerative brain syndrome that affects more than 37 million people worldwide, first described by Alois Alzheimer in 1906. Dementia of the Alzheimer type leads to a progressive decline in memory with concomitant hindering of thinking, social cognition, comprehension and learning capabilities. AD accounts for most cases of dementia that are diagnosed after the age of 60. AD affects approximately 20 million people all over the world and imposes an annual economic burden of about 100 US$ billion. The disease characterized pathologically by the presence of extracellular senile plaques and intracellular neurofibrillary tangles in the brain. The major constituent of the senile plaques is Aβ-peptide. This peptide is generated physiologically after proteolytic processing of a larger membrane bound precursor protein, known as the APP, cleavage of APP by beta-secretase releases the extracellular APPβ fragment. Products were designed and docked into the active site of the enzyme, crystal structure and diverse scaffold used accordingly. Solution phase chemistry applied for the synthesis of the designed compounds by reacting Indole-3-Acetic Acid Ethyl Ester with Hydrazine Hydrate forming Hydrazide, which was condensed with different aldehydes to afford Schiff’s bases then it was cyclized with thioglygolic acid. All of the prepared compounds were tested in-vitro for β-secretase inhibitory activity.
Papers by Mo'men A . Salem
ABSTRACT The resurgence of tuberculosis from a forgotten disease to a modern and resurgent pathol... more ABSTRACT The resurgence of tuberculosis from a forgotten disease to a modern and resurgent pathology is a matter of serious global concern. Development and transmission of Multi Drug-Resistant (MDR) and extensively drug-resistant (XDR) tuberculosis is an important public health problem worldwide. This review covers mainly the therapeutic limitations to treat these resistant disease forms, as well as, the current status of drug discovery and development for anti-tubercular therapy and treatment. develop new, better treatments for TB after decades of stagnation. However, the euphoric mood can turn to pessimism as the road to adequate treatment for people with TB is still a long one and full of many difficulties. Anti-mycobacterial therapy though available; drugs are often partially effective because of the impermeable nature of the mycobacterium cell wall and the propensity of Mtb to develop resistance to the existing drugs in TB therapy [7]. Additionally, Mtb has the capacity to remain viable within infected hosts for a prolonged time. Notably, MDR-TB and XDR-TB have become obstacles to the effective global TB control and have been recognized by the WHO as major challenges to be addressed in the fight against tuberculosis [8,9]. A key strategy to combat and destroy these drug resistant pathogens is the discovery of novel antitubercular agents bearing newer structural skeletons (scaffolds), acting through novel mechanisms of action and bearing no or minimal cross resistance.
International Journal of Organic Chemistry
In this work, some new oxadiazole derivatives have been prepared, by reacting phenyl hydrazine an... more In this work, some new oxadiazole derivatives have been prepared, by reacting phenyl hydrazine and acetic anhydride together, which furnished 2,4dimethyl-4-phenyloxadiazole. This product was reacted with a series of aromatic aldehydes, to obtain a series of oxadiazole derivatives. These derivatives were characterized by TLC, melting points, infrared red, proton nuclear magnetic resonance, carbon thirteen nuclear magnetic resonance and mass spectroscopy. Finally, these synthetized derivatives were tested for antiproliferative activity by two different cell lines. MCF-7 (Breast cancer cell line) and HepG2 (Liver cancer cell line) were used to assess the antiproliferative activity of the prepared compounds.
Ulcer Index, Analgesics and Anti inflammatory Screening of Some Arylidene Compounds Derived from Phenyl Hydrazine and Aromatic Aldehydes, 2022
Arylidene derivatives were synthesized from phenyl hydrazine and series of different aldehydes. A... more Arylidene derivatives were synthesized from phenyl hydrazine and series of different aldehydes. Arylidene compounds are important classes of N-containing fused heterocycles widely used as key building blocks for pharmaceutical agents due to a wide range of biological activities that include anti-inflammatory and antitumor properties [1]. Arylidene derivatives were furnished by the fusion of benzene ring with different aldehydes via hydrazine moiety in the presence of glacial acetic acid. These derivatives were characterized by TLC, melting points, Infrared Red, Nuclear Magnetic Resonance and Mass Spectroscopy. Finally, these synthetized derivatives were tested for analgesic activity using hot plate test method, anti-inflammatory activity using rat paw oedema and ulcer index test.
In this work, some new oxadiazole derivatives have been prepared, by reacting phenyl hydrazine an... more In this work, some new oxadiazole derivatives have been prepared, by reacting phenyl hydrazine and acetic anhydride together, which furnished 2,4dimethyl-4-phenyloxadiazole. This product was reacted with a series of aromatic aldehydes, to obtain a series of oxadiazole derivatives. These derivatives were characterized by TLC, melting points, infrared red, proton nuclear magnetic resonance, carbon thirteen nuclear magnetic resonance and mass spectroscopy. Finally, these synthetized derivatives were tested for antiproliferative activity by two different cell lines. MCF-7 (Breast cancer cell line) and HepG2 (Liver cancer cell line) were used to assess the antiproliferative activity of the prepared compounds.
International Journal of Organic Chemistry, 2022
In this work we synthesized new derivatives from Phenyl Hydrazine and series of different Aldehyd... more In this work we synthesized new derivatives from Phenyl Hydrazine and series of different Aldehydes (derivatives of benzylidenes). The synthesized compounds contain different aromatic Aldehydes which attached by Benzene ring via Hydrazine moiety in glacial acetic acid. These derivatives were characterized by TLC, melting points, Infrared Red, Proton Nuclear Magnetic Resonance, Carbon Thirteen Nuclear Magnetic Resonance and Mass Spectroscopy. Finally, these synthesized derivatives were tested for antiproliferative activity against multiple normal and cancerous cell lines, HepG2 (Liver cancer) and MCF-7 (Breast cancer) cell lines were used for cytotoxic assay.
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Conference Presentations by Mo'men A . Salem
Papers by Mo'men A . Salem