Enoksacin

Enoksacin
(IUPAC) ime
	1-etil-6-fluoro-4-okso-7-(piperazin-1-il)-1,4-dihidro-1,8-naftiridin-3-karboksilna kiselina
Klinički podaci
AHFS/Drugs.com	Monografija
MedlinePlus	a601013
Identifikatori
CAS broj	74011-58-8
ATC kod	J01MA04
PubChem	3229
DrugBank	DB00467
ChemSpider	3116
UNII	325OGW249P
KEGG	D00310
ChEBI	CHEBI:157175
ChEMBL	CHEMBL826
Hemijski podaci
Formula	C15H17FN4O3
Mol. masa	320,319 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23) ; Key: IDYZIJYBMGIQMJ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	Oralno

Enoksacin (Almitil, Bactidan, Bactidron, Comprecin, Enoksetin, Enoxen, Enroxil, Enoxin, Enoxor, Flumark, Penetrex, Gyramid, Vinone) je oralni fluorohinolonski antibakterijski agens širokog spektra koji se koristi u tretmanu infekcija urinarnog trakta i gonoreja. Insomnija je česta nuspojava pri upotrebi ovog leka.^[6]^[7]

Nedavno je pokazano da ova supstanca može da inhibira kancer.^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Rafalsky, V.; Andreeva, I.; Rjabkova, E.; Rafalsky, Vladimir V (2006). Rafalsky, Vladimir V. ur. „Quinolones for uncomplicated acute cystitis in women”. Cochrane Database Syst Rev 3: CD003597. DOI:10.1002/14651858.CD003597.pub2. PMID 16856014.
↑ Mogabgab, WJ. (Dec 1991). „Recent developments in the treatment of sexually transmitted diseases”. Am J Med 91 (6A): 140S–144S. DOI:10.1016/0002-9343(91)90327-T. PMID 1767802.
↑ Sonia Melo, Alberto Villanueva, Catia Moutinho, Veronica Davalos, Riccardo Spizzo, Cristina Ivan, Simona Rossi, Fernando Setien, Oriol Casanovas, Laia Simo-Riudalbas, Javier Carmona, Jordi Carrere, August Vidal, Alvaro Aytes, Sara Puertas, Santiago Ropero, Raghu Kalluri, Carlo M. Croce, George A. Calin, Manel Estellera (2011). „Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing”. PNAS. DOI:10.1073/pnas.1014720108. Arhivirano iz originala na datum 2014-08-26. Pristupljeno 2014-04-05.

Literatura

Patel SS, Spencer CM (January 1996). „Enoxacin: a reappraisal of its clinical efficacy in the treatment of genitourinary tract infections”. Drugs 51 (1): 137–60. PMID 8741236. .

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Medline entry

Šablon:Antibiotici inhibitori nukleinskih kiselina

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Rafalsky, V.; Andreeva, I.; Rjabkova, E.; Rafalsky, Vladimir V (2006). Rafalsky, Vladimir V. ur. „Quinolones for uncomplicated acute cystitis in women”. Cochrane Database Syst Rev 3: CD003597. DOI:10.1002/14651858.CD003597.pub2. PMID 16856014.

[7] Mogabgab, WJ. (Dec 1991). „Recent developments in the treatment of sexually transmitted diseases”. Am J Med 91 (6A): 140S–144S. DOI:10.1016/0002-9343(91)90327-T. PMID 1767802.

[8] Sonia Melo, Alberto Villanueva, Catia Moutinho, Veronica Davalos, Riccardo Spizzo, Cristina Ivan, Simona Rossi, Fernando Setien, Oriol Casanovas, Laia Simo-Riudalbas, Javier Carmona, Jordi Carrere, August Vidal, Alvaro Aytes, Sara Puertas, Santiago Ropero, Raghu Kalluri, Carlo M. Croce, George A. Calin, Manel Estellera (2011). „Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing”. PNAS. DOI:10.1073/pnas.1014720108. Arhivirano iz originala na datum 2014-08-26. Pristupljeno 2014-04-05.

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