Vidarabin je nukleozidni antibiotik izolovan iz Streptomyces antibioticus. On poseduje antineoplastična svojstva i ima širok spektrar dejstva protiv DNK virusa u ćelijskim kulturama. On ima znatnu antiviralnu aktivnost protiv infekcija uzrokovanim mnoštvom različitih virusa, kao što je herpes virus.[6][7]
Vidarabin
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| (IUPAC) ime
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| (2R,3S,4S,5R)-2-(6-amino-9H-purin-9-il)-5-(hidroksimetil)oksolan-3,4-diol
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| Klinički podaci
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| Robne marke
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Arasena-A, Spongoadenosine, Vidarabin, Vira-A
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| AHFS/Drugs.com
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Monografija
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| Identifikatori
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| CAS broj
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24356-66-9
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| ATC kod
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J05AB03 , S01AD06
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| PubChem[1][2]
|
32326
|
| DrugBank
|
DB00194
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| ChemSpider[3]
|
29966
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| KEGG[4]
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C07195  Y
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| ChEMBL[5]
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CHEMBL45327 Y
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| Hemijski podaci
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| Formula
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C10H13N5O4
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| Mol. masa
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267.2413
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1
Key: OIRDTQYFTABQOQ-UHTZMRCNSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
|
?
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| Pravni status
|
|
| Način primene
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Oftalmički
|
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.
