recurrent group (10.4 Ϯ 2.5%) was significantly higher than that in nonrecurrent group (4.3 Ϯ 1.2... more recurrent group (10.4 Ϯ 2.5%) was significantly higher than that in nonrecurrent group (4.3 Ϯ 1.2%, p Ͻ 0.05). Conclusions: Our results indicated that more extensive disease involving the ileum and ocular lesions may be the predictive factors of severity, progression to surgical crisis and recurrence. Furthermore, increased percentage of peripheral CD8ϩDRϩ lymphocytes may be a risk factor for disease recurrence. 458 The influence of strain specific Helicobacter pylori and serum gastrin levels on development of colon adenocarcinoma Noshirwaim KC MD, Hood RL MD, Smalley WE MD, Delvalle J MD, Perez-Perez G PhD, Peek RM MD. Vanderbilt University Hospital and the VAMC, Nashville, TN.
Cytoreductive chemotherapy and immunosuppression have been postulated as possible adjuncts to can... more Cytoreductive chemotherapy and immunosuppression have been postulated as possible adjuncts to cancer immunotherapy in studies using murine tumour-infiltrating lymphocytes (TIL). Treatment of animals with cyclophosphamide (Cv) therapy alone caused two distinct biological activities that altered the relationship between host and tumour. These two in who activities were distinguished by altering the timing and dose of Cy administration relative to tumour implantation. Cy administered 3 days following tumour injection caused a significant decline in the number of pulmonary micrometastases and greater survival compared to untreated controls in proportion to the dose of Cy administered. Further reduction in pulmonary disease was observed when Cytreated mice were given TIL therapy. The possible role(s) of Q-induced immunosuppression was studied by injecting Cy 24 h prior to tumour injection. This treatment failed to cause the cytoreductive effect observed when Cy was administered 3 days after tumour since Q-administration prior to tumour resulted in a significantly higher number of pulmonary metastases and diminished survival compared to untreated controls. Despite the increased number of pulmonary metastases and decreased survival in mice treated with Cy before administration of tumour, therapy with TIL significantly diminished pulmonary disease compared to animals treated with Cy alone. lmmunosuppression (without concomitant cytoreductive therapy) prior to TIL treatment significantly prolonged survival. Additional studies with TIL therapy indicate that the survival of animals immunosuppressed prior to tumour injection was significantly longer than controls which received immunotherapy alone. These results suggest that the combustion of immunosuppression plus cellular immunotherapy, which leads to significant survival advantage in these murine tumour models, may possibly augment the clinical response in human TIL trials. Surgica/ Onco/ogy 1992; 1: 27-35.
recurrent group (10.4 Ϯ 2.5%) was significantly higher than that in nonrecurrent group (4.3 Ϯ 1.2... more recurrent group (10.4 Ϯ 2.5%) was significantly higher than that in nonrecurrent group (4.3 Ϯ 1.2%, p Ͻ 0.05). Conclusions: Our results indicated that more extensive disease involving the ileum and ocular lesions may be the predictive factors of severity, progression to surgical crisis and recurrence. Furthermore, increased percentage of peripheral CD8ϩDRϩ lymphocytes may be a risk factor for disease recurrence. 458 The influence of strain specific Helicobacter pylori and serum gastrin levels on development of colon adenocarcinoma Noshirwaim KC MD, Hood RL MD, Smalley WE MD, Delvalle J MD, Perez-Perez G PhD, Peek RM MD. Vanderbilt University Hospital and the VAMC, Nashville, TN.
Cytoreductive chemotherapy and immunosuppression have been postulated as possible adjuncts to can... more Cytoreductive chemotherapy and immunosuppression have been postulated as possible adjuncts to cancer immunotherapy in studies using murine tumour-infiltrating lymphocytes (TIL). Treatment of animals with cyclophosphamide (Cv) therapy alone caused two distinct biological activities that altered the relationship between host and tumour. These two in who activities were distinguished by altering the timing and dose of Cy administration relative to tumour implantation. Cy administered 3 days following tumour injection caused a significant decline in the number of pulmonary micrometastases and greater survival compared to untreated controls in proportion to the dose of Cy administered. Further reduction in pulmonary disease was observed when Cytreated mice were given TIL therapy. The possible role(s) of Q-induced immunosuppression was studied by injecting Cy 24 h prior to tumour injection. This treatment failed to cause the cytoreductive effect observed when Cy was administered 3 days after tumour since Q-administration prior to tumour resulted in a significantly higher number of pulmonary metastases and diminished survival compared to untreated controls. Despite the increased number of pulmonary metastases and decreased survival in mice treated with Cy before administration of tumour, therapy with TIL significantly diminished pulmonary disease compared to animals treated with Cy alone. lmmunosuppression (without concomitant cytoreductive therapy) prior to TIL treatment significantly prolonged survival. Additional studies with TIL therapy indicate that the survival of animals immunosuppressed prior to tumour injection was significantly longer than controls which received immunotherapy alone. These results suggest that the combustion of immunosuppression plus cellular immunotherapy, which leads to significant survival advantage in these murine tumour models, may possibly augment the clinical response in human TIL trials. Surgica/ Onco/ogy 1992; 1: 27-35.
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