Papers by Pınar Karabağlı
Journal of Pediatric Hematology Oncology, May 12, 2023
Ginekologia Polska, Jan 31, 2023
This article is available in open access under Creative Common Attribution-Non-Commercial-No Deri... more This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
Selçuk Tıp Dergisi, Dec 7, 2006
Gynecology Obstetrics and Reproductive Medicine, Dec 10, 2011
Türkiye Ekopatoloji Dergisi, 2013
... Pınar Karabağlı Berrin Güçlüer Gülhan Erdinçler Nazan Aksoy Aysun Barlas SSKB Göztepe Eğitim ... more ... Pınar Karabağlı Berrin Güçlüer Gülhan Erdinçler Nazan Aksoy Aysun Barlas SSKB Göztepe Eğitim Hastanesi Patoloji Laboratuarı, İstanbul ... Bunlardan yalnızca 3'ü Derece II'dir. Gezen ve ark.nın 76 olguluk dizisinde ise meningiom yineleme oranı %6,4`dür (29). Page 6. ...
Turkiye Klinikleri Journal of Dermatology, 2014
Urology, Aug 1, 2016
Objective: To evaluate the hemostatic efficacy and histopathological effects of Ankaferd Blood St... more Objective: To evaluate the hemostatic efficacy and histopathological effects of Ankaferd Blood Stopper ® (ABS) in an experimental rat model of cyclophosphamide-induced (CYP) hemorrhagic cystitis (HC). Methods: Forty male Sprague-Dawley rats were included in the study. Firstly, 10 rats were divided equally into 2 groups where the first group was administered only an intraperitoneal (i.p.) injection of normal saline to constitute the negative control group (CON). The remaining 5 rats were administered only a single i.p. injection of CYP (without any further treatment) for induction of HC to constitute the positive control group (HC). Subsequently, remaining 30 rats, which also received i.p. CYP for induction of HC, were divided into 3 groups to which intravesical saline (SAL group), epinephrine (EPN group), and ABS (ANK group) were administered for 3 consecutive days. Ten days after the third instillation, Page 2 of 25 3 cystectomy was performed for histopathological examination. Specimens were evaluated for presence of congestion, edema, necrosis, ulceration and regenerated epithelium, and scores were given for each parameter according to the severity. Results: No statistically significant difference was observed for congestion, edema, necrosis and ulceration between HC-SAL, and also between CON-ANK groups (all p values >0.05). There was a significant difference for total scores between EPN and ANK groups (p=0.009). There was statistically significant difference for regenerating epithelium between CON-EPN, CON-ANK, HC-ANK and SAL-ANK groups. Conclusions: Intravesical administration of ABS is at least as efficacious as EPN in terms of congestion, edema, necrosis and ulceration. Moreover, ABS can be considered as a better option in inducing regenerating epithelium than EPN.
PubMed, Oct 1, 2016
A 21-year-old woman (born of consanguineous parents) presented with asymptomatic, waxy, white, be... more A 21-year-old woman (born of consanguineous parents) presented with asymptomatic, waxy, white, beaded papules along the eyelid margins of 6 years’ duration. Physical examination revealed moniliform blepharosis over the eyelid margins, multiple linear and pocklike scars on the face and arm, pebbling on the lower lip and oropharynx, and hoarseness that was present since early infancy. Medical history was unremarkable for systemic disorders and routine laboratory tests were within reference range. Pathological examination of a papule on the lower lip mucosae revealed perivascular deposition of eosinophilic homogeneous material.
Electronic journal of general medicine, Jan 8, 2014
Spindle cell lipoma is a rare lipoma, originates from subcutaneous tissue and mostly seen at back... more Spindle cell lipoma is a rare lipoma, originates from subcutaneous tissue and mostly seen at back region. In this case report we represent a case with inguinal mass misdiagnosed as inguinal hernia and then diagnosed as spindle cell lipoma. There are two cases in literature with spindle cell lipoma originating from spermatic cord. This case is unique as having both pheochromacytoma and inguinal spindle cell lipoma mistaken as inguinal hernia.
Retiform hemangioendothelioma is recently defined, a distinctive variant of low-grade angiosarcom... more Retiform hemangioendothelioma is recently defined, a distinctive variant of low-grade angiosarcoma of the skin. It has a potential of high local recurrence but low distant metastasis. Because there have been no tumor-related deaths and only two case of regional lymph node metastasis; wide surgical excision is the most suggested treatment method. We document a case of retiform hemangioendothelioma that is originated from the capillary malformation of the left arm skin of an 8-year-old girl. Our case is discussed in the background of previously reported cases concerning retiform hemangioendothelioma in English-written literature. As far we know this is the first case of the retiform hemangioendothelioma originating from the capillary malformation and she is the youngest case.
PubMed, 2015
Via routinely used thyroid function tests, scintigraphy and ultrasonography (USG), important info... more Via routinely used thyroid function tests, scintigraphy and ultrasonography (USG), important information is obtained in the clinical and diagnostic practice for thyroid nodules. However, the distinction between benign and malignant lesions cannot precisely be performed with these tests. Thyroid fine needle aspiration biopsy (FNAB) is considered the most reliable diagnostic method in the differentiation between benign and malignant thyroid nodules. It has recently been likely to perform aspiration from deeper nodules via the implemention of FNAB along with USG. Today, in cytopathological examination of thyroid FNAB, standardized Bethesda System for Reporting Thyroid Cytopathology (BSRTC) system is used. Here, FNAB was performed in 1096 patients with thyroid nodules in the Medical School of Selcuk University between January 2009 and July 2014. Patients consisted of 919 women and 177 men between 12 and 87 years of age. Evaluated via BSRTC, the results were classified as unsatisfactory, benign, atypia (or follicular lesions) of undetermined significance (AUS), follicular neoplasm or lesions suspicious for follicular neoplasm (FN), suspected malignant and malignant. After FNAB, 183 patients were operated and evaluated histopathologically. Histological malignancy rates of the categories were as follows: 16% (5), 15% (6) 14% (1) 60% (9), 72% (18) and 97% (63), respectively. In our study, we aimed to compare FNAB results of thyroid nodules with histopathology results after thyroidectomy and to show the sensitivity and specificity of FNAB technique to be higher in the follow-up and diagnosis of thyroid lesions. Given the malignancy detection rate in the follow-up of patients whose cytology was reported as inadequate, we also consider follow-ups are important in these patients.
PubMed, Sep 2, 2017
Purpose: To evaluate the emotional, sexual and health-related quality of life (HRQoL) concerns of... more Purpose: To evaluate the emotional, sexual and health-related quality of life (HRQoL) concerns of the women with gynecologic malignancy treated with curative radiotherapy (RT). Patients and methods: A 100 women with diagnosis of gynecologic malignancy were prospectively enrolled. HRQoL at baseline, at the end of RT and during follow-up was assessed using European Organization for Research and Treatment of Cancer QoL Questionnaire-C30 (EORTC QLQ-C30), EORTC QLQ-cervical cancer module 24, and Hospital Anxiety and Depression Scale. Results: The appetite loss, diarrhea, fatigue, dyspnea, insomnia, nausea and vomiting, pain scores, and sexual activity and sexual enjoyment scores were deteriorated after RT (P = 0.02 for pain scores and P < 0.001 for all other). Body image scores were higher in patients with endometrial cancer (P < 0.01). The emotional function, nausea and vomiting, body image and symptom experience scores were higher in patients who underwent chemotherapy (P = 0.04 and P = 0.01). All the complaints of patients improved during follow-up period. The global health status scores and the level of depression deteriorated in patients with locoregional recurrent disease and distant metastasis. The anxiety (P = 0.001) and depression (P = 0.007) levels were higher in basal and after-RT visits but then decreased through the subsequent follow-up visits. Conclusion: Although pelvic RT deteriorated HRQoL in patients with gynecologic malignancy, HRQoL improved during the follow-up period. The progressive disease had a negative impact on HRQoL.
Cukurova Medical Journal, Dec 28, 2022
Ahi evran medical journal, Mar 4, 2021
Bilgisayarlı histomorfometrik analiz, meme karsinomlarını da içeren pek çok tümörün ayırıcı tanıs... more Bilgisayarlı histomorfometrik analiz, meme karsinomlarını da içeren pek çok tümörün ayırıcı tanısında kullanılan bir araç olup, malign tümörlerin derecelendirmesinde, prognoz ve tedavi yanıtının değerlendirilmesinde de denenmiştir. Bu çalışmada meme karsinomlarında nükleer morfometrik değişkenler ile klinikopatolojik prognostik parametreler ve immünohistokimyasal ER, PR, Cerb-B2 ekspresyonları arasındaki ilişkiyi araştırmak amaçlanmıştır. Araçlar ve Yöntem: Çalışmada meme karsinomu tanısı alan 105 olguda, ortalama nükleus alanı (ONA), ortalama nükleus çevresi (ONÇ), ortalama nükleus uzun çapı (ONUÇ) ve ortalama nükleus kısa çapı (ONKÇ) dahil olmak üzere çeşitli nükleer morfometrik parametreler açısından değerlendirildi. Dijital görüntü analiz sistemi kullanılarak Hematoksilen-eosin ile boyanmış lamlar üzerinde, lezyon başına elli tümör hücre çekirdeğinde ölçümler yapıldı. Elde edilen veriler ile klinikopatolojik prognostik parametreler arasındaki ilişki istatistiksel yöntemler ile değerlendirildi. Bulgular: Histolojik gruplar arasında, invaziv duktal karsinomada (IDK), diğer tümör gruplarına göre ONUÇ (p=0.04) daha yüksek saptanmştır. Derece 3 IDK olgularında, derece 1 IDK olgularına göre ONKÇ (p=0.04); İnvaziv Lobler Karsinom olgularına göre de ONA (p<0.01), ONÇ (p=0.02), ONUÇ (p=0.01) ve ONKÇ (p=0.02) daha yüksek saptanmıştır. Tümör nekrozuna sahip olgularda, tümör nekrozu olmayan olgulara göre ONA (P=0.01), ONÇ (p<0.01), ONUÇ (P=0.01) ve ONKÇ (P<0.01) daha yüksek saptanmıştır. Immünohistokimyasal olarak, Cerb-B2 pozitif meme karsinomlu olgular, Cerb-B2 negatif olgulara göre ONA (P<0.01), ONÇ (p=0.01), ONUÇ (P<0.01) ve ONKÇ (P=0.01) daha yüksek saptanmıştır. Sonuç: Özellikle nükleus alanına dayalı nükleer morfometrik değerlendirme; tümör derecesi, histolojik subtip ve tümör nekrozu yanısıra Cerb-B2 ekspresyon profili ile ilişkili olduğundan prognostik değerlendirmede yol gösterici olabilir.
International Journal of Dermatology, Nov 16, 2020
Unilateral idiopathic acquired dermal melanocytosis on a palm: An extremely rare entity in a youn... more Unilateral idiopathic acquired dermal melanocytosis on a palm: An extremely rare entity in a young woman Dear Editor, Dermal melanocytoses (DMs) are characterized by bluishgray hyperpigmented macules. DMs are generally observed at birth and rarely in adolescence or adulthood and are called acquired dermal melanocytosis (ADM). ADM is extremely rare in the acral regions. 1,2 Here, we present a 20-year-old Turkish woman diagnosed with ADM on the right palm. A 20-year-old female patient presented to the dermatology outpatient clinic with discoloration on the right palm for 2 years. She was a student and ambidextrous. There were no triggering factors like inflammation, severe sunlight exposure, trauma, inflammatory dermatosis, chemical substance, metal contact, or use of drugs. Her family history was unremarkable, and she did not benefit from hydroquinone treatment. The lesions were
Clinical Case Reports, Aug 4, 2019
Acute generalized exanthematous pustulosis (AGEP) is a pustular severe cutaneous adverse reaction... more Acute generalized exanthematous pustulosis (AGEP) is a pustular severe cutaneous adverse reaction usually based on the drugs. We report a 64-year-old woman who developed AGEP after a 20-day course of hydroxychloroquine and might be treated with cyclosporine because of unresponsiveness to the first-line treatments. Severe cutaneous adverse reactions to drugs are associated with morbidity, mortality, healthcare costs, and drug development challenges. They are a wide spectrum of entities consisting of Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms syndrome, and acute generalized exanthematous pustulosis (AGEP). 1 The term of AGEP is first used in 1980 by Beylot et al in the medical literature as a separate entity. 2 It is a rare adverse drug reaction represented by suddenly onset of widespread nonfollicular sterile pustules on erythematous and edematous plaques, high fever (>38°C), and neutrophilia (>5000/mL). The initial lesions start from the face and fold areas and rapidly dissipate. Targetoid lesions and purpura
İç Anadolu tıp dergisi, 2021
Öz Amaç: Kolorektal kanserler arasında her evrede sağkalımın en olumsuz olduğu tümörler rektum ka... more Öz Amaç: Kolorektal kanserler arasında her evrede sağkalımın en olumsuz olduğu tümörler rektum kanserleridir. Bununla birlikte cerrahi tekniğin optimizasyonu ve neo-adjuvan tedavi yaklaşımı, son yıllarda rektum kanserlerinde 5 yıllık sağ kalım sürelerinin kolon kanserinden daha iyi olmasına neden olmuştur. Erken evre rektum tümörlü hastaların tedavisinde küratif tedavinin köşe taşı cerrahidir. Ancak transmural invazyon ve/veya pozitif perirektal lenf nodu olan hastalarda, hastalığın lokal kontrolü ve kürü açısından olumlu sonuçlar elde edebilmek için cerrahi tedaviye radyoterapi ve kemoterapinin eklenmesi gerekir. Kanser kök hücre belirteci olan ALDH1 ekspresyonunun kemoterapiye rezistansta, tümör progresyonunda ve metastazında anlamlı olduğu yapılan çalışmalarda gösterilmiştir. Ayrıca metastatik ve ileri evre meme over, karaciğer, prostat ve kolon kanserlerinde normal dokudan farklı olarak anormal gamma synuclein ekspresyonu varlığı da gösterilmiştir. Gamma synuclein ekspresyonu meme kanser hücrelerinin proliferasyonu, invazyonu ve metastazıyla ilişkili bulunmuştur. Gereç ve Yöntem: Çalışmamızda rektum rezeksiyon materyallerinden rektal adenokarsinom tanısı alan 55 olguya ait tümöral ve normal mukoza örnekleri incelendi. Prognostik parametreler ile ALDH 1 ve Gamma synuclein antikorlarının ekspresyonları arasındaki ilişki araştırıldı. Bu şekilde çalışmamızda rektum kanserinde gamma-synuclein ve ALDH1 ekspresyonu ile tümör agresivitesi ve prognozu üzerine etkilerini belirlemeyi amaçladık. Bulgular: İmmunohistokimyasal olarak Gamma synucleinin rektum kanseri ve normal mukozasında boyanmadığı görüldü. ALDH 1 ile farklı boyanma paternleri saptanarak bulgular literatür eşliğinde yorumlandı. Sonuç: Çalışmamızda rektum kanseri ve normal mukozal dokuda derece, evre, lenf nodu metastazı, Lenfovasküler invazyon ve Perinöral invazyon ile ALDH1 ekspresyonu arasında istatiksel olarak anlamlı olmayan, boyanma kuvveti açısından ters orantılı bir ilişki saptandı. Gamma synucleinin ise rektum kanserlerinde eksprese olmadığı görülmüştür.
İç Anadolu tıp dergisi, Apr 25, 2016
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