Journal of Blood Disorders & Transfusion, 2014
People living with HIV/AIDS in 2010 are around 34 million, already; more than 30 million people a... more People living with HIV/AIDS in 2010 are around 34 million, already; more than 30 million people around the world have died of AIDS-related diseases. In 2010, 2.7 million people were newly infected with HIV, and 1.8 million men, women and children died of AIDSrelated causes [9].
Sexually transmitted infections (STIs) are group of diseases that are transmitted by vaginal, ana... more Sexually transmitted infections (STIs) are group of diseases that are transmitted by vaginal, anal or oral intercourse. They can be viral, bacterial, parasitic or protozoal infection. Every day more than one million STIs acquired (Ott & Santelli, 2019). Viral warts are benign growths that are caused by human papillomavirus (HPV) infection that infect skin and mucosa. HPV has more than 120 subtypes, and it is a double-stranded DNA virus. Genital warts commonly occur in perigenital areas and perianal areas, and they are usually asymptomatic. The occurring inflammation due to warts causes some sort of imbalance of oxidant versus antioxidant systems in tissues (Cokluk et al., 2015). Reactive oxygen species (ROS) as molecular oxygen (O 2), hydroxyl radicals (OH −), superoxide anion (O − 2) and hydrogen peroxide (H 2 O 2) in low levels participate in multiple cellular processes, such as cell differentiation cell proliferation, immune responses and apoptosis (Trouba, Hamadeh, Amin, & Germolec, 2002).
Introduction and aim: Genital wart infection is a distressing sexually transmitted infection that... more Introduction and aim: Genital wart infection is a distressing sexually transmitted infection that causes marked fear and stress to both males and females. Tuberculin Purified protein derivative (PPD) injection is an upcoming safe and effective modality for the treatment of genital warts. Interleukin 17 (IL-17) was found to be lower in wart patients than controls. This study aimed at measurement of serum level of IL-17 in genital warts patients before and after PPD injection. Patients and methods: The study was carried out as case-control interventional study on 63 patients (37 males and 26 females) with genital warts attending Dermatology and Andrology Clinics, faculty of medicine, Suez Canal University hospitals. 50 controls were enrolled in the study. All patients have injected 10 tuberculin units of PPD intradermally in the mother or largest warts every 2 weeks till 6 sessions. Serum level of IL-17 was measured by Sandwich ELISA technique to all patients before and after PPD injection and to all control subjects. Results: The mean age of patients was 30.8 years, the mean duration of warts was 4.73 months, the mean number of warts was 9.76 warts and 14.3% of patients experienced side effects to PPD. (58.7%) of patients were completely recovered from warts. Mean serum IL-17 was 81.1 ± 64.2 pg/mL versus 118.9 ± 93.8 pg/mL in genital wart patients versus controls respectively (P < 0.05) and 81.1 ± 64.2 pg/mL versus 107.1 ± 66.8 pg/mL before and after PPD injection respectively (P < 0.05). Conclusion: IL-17 serum level was significantly lower in genital wart patients than normal controls. IL-17 serum level had been increased significantly after PPD intralesional injection than pretreatment levels and significantly related to clinical response to PPD. IL-17 suggested having a role in the clinical efficacy of PPD in the treatment of genital warts.
Background: Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering ... more Background: Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering and heterogeneity in the onset and progression indicate that susceptibility to CSU is a complex trait. In this study, we performed haplotype analysis for one of the key player gene, IL17RA, for CSU to test the association with disease susceptibility and severity. Methods The study included 70 CSU patients and 30 healthy controls. The severity of the disease was evaluated by autologous serum skin test (ASST) and urticaria activity score (UAS). ASST test was done and quality of life was assessed using a questionnaire. Allelic discrimination analysis for rs4819554 and rs879577 was performed using Real-Time Polymerase Chain Reaction technology. Results: Carriers of rs4819554*G were more prone to develop CSU than its counterpart (p = 0.039), while rs4819554*A allele displayed more severe phenotype in the form of more prolonged disease duration (p = 0.040), concurrent angioedema (p < 0.001), higher level of treatment (p < 0.001), and higher score of quality of life (p < 0.001). Additionally, homozygote patients with rs879577*CC were associated with angioedema (p < 0.001). Haplotype analysis revealed that cohorts with both rs4819554*A and rs879577*T conferred protection against developing CSU (OR = 0.07, 95%CI = 0.01-0.32, p = 0.001). Conclusions: Our results showed that IL17RA gene polymorphisms might contribute to the increased susceptibility to CSU. Biochemical analysis Liver function tests, complete blood count (CBC), erythrocyte sedimentation rate, a parasite stool test, and complete urine analysis were performed in the clinical pathology department laboratories. Allelic discrimination analysis by real-time PCR DNA extraction from blood leukocytes was done using QIAamp DNA Blood Mini kits (Qiagen, Clinilab Co., Egypt, Catalog no. 51104), according to the manufacturer's instructions. Genotyping of the promoter variant (rs4819554, c.-947G > A) and the missense mutation (rs879577, c.1100C > T; p.A367E or p. 367V) was performed using real-time polymerase chain reaction (RT-PCR) using TaqMan® genotyping assay (Applied Biosystem, assay ID C__337392_30 and C__2666446_20) as previously described [17]. Statistical analysis Statistical analysis was carried out using SPSS software, version 26.0. The test for normality was performed using the Shapiro-Wilk test. Descriptive statistics were represented as mean ± standard deviation (SD) for quantitative variables and percentages for qualitative variables. For qualitative variables, the Chi-square and Fisher's Exact tests were used. For quantitative variables, the student's t and Kruskal-Wallis tests were used for non-parametric variables. A p-value < 0.05 was considered statistically signi cant, and all statistical tests were two-sided.
Introduction: Sexual relationships are an integral part of females psychological and physiologica... more Introduction: Sexual relationships are an integral part of females psychological and physiological wellbeing. Objectives: The study aimed to identify prevalence and impact of Female Sexual Dysfunction (FSD) in women affected with psoriasis. Methods: This cross-sectional study was carried out on 150 married females who were interviewed to answer Female Sexual Function Index (FSFI) questionnaire and were divided into two groups: the first group included 100 female patients complaining of psoriasis (50 suffering from moderate psoriasis and 50 with severe psoriasis). The disease severity was graded according to the Psoriasis Area and Severity Index (PASI) while the second group included 50 age matched women who served as controls. Results: Female sexual dysfunction (FSD) in psoriasis female groups was higher than that in the control group (47%, 24%, P < 0.05). The mean total scores of FSFI ranged from 12.30 to 34.20 and were significantly lower in the severe PASI affected group (22.3...
Background: Anogenital warts are growths caused by human papilloma virus infection, which causes ... more Background: Anogenital warts are growths caused by human papilloma virus infection, which causes significant psychosocial morbidity. Intralesional immunotherapy is a promising treatment that is able to stimulate a delayed-type hypersensitivity reaction to different antigens as well as wart tissue. This treatment is suggested to increase CD4 T helper 1 lymphocyte activity to destroy human papilloma virus. Objective: To measure the level of serum soluble CD4 (sCD4) in patients with anogenital after intralesional tuberculin purified protein derivative (PPD) injection. Patients and Methods: This study was carried out as a pre-post interventional study on 49 patients with anogenital warts presented to the dermatology clinic and the andrology clinic, Suez Canal University Hospital. Each patient was injected 10U (0.2ml) of PPD intralesionally in the largest or mother wart with 2-week interval till complete cure or six injections, whichever was closer. Serum sCD4 was measured before and after injection using sandwich ELISA technique. Results: Complete clinical wart recovery was obtained in 26 (53%) patients and mostly was after the sixth session (60.4%) of injection. Mean level of serum sCD4 was significantly higher after than before PPD injection (18.47±10.4 vs. 44.48±20.67ng/ml, respectively). Serum sCD4 levels were significantly correlated to clinical response rates, as the higher the level of serum sCD4, the more the wart recovery. Conclusion: Intralesional PPD injection is a promising effective modality in the treatment of anogenital warts. CD4 cells may have a role in anogenital wart eradication by PPD injection and significantly related to clinical response rates.
ABSTRACTBackgroundEfficacy and safety of ablative fractional laser used for treatment of acne sca... more ABSTRACTBackgroundEfficacy and safety of ablative fractional laser used for treatment of acne scars have been described in several studies. Recently, microneedling radiofrequency treatment has been showing promising results with low risk of side effects and rapid healing time.ObjectiveTo study efficacy and safety of ablative fractional Er:YAG laser 2940 nm and microneedling radiofrequency for facial atrophic acne scar.Methods21 patients with atrophic postacne scars were randomized to MRF for one half of the face and laser for the other half. Four sessions were performed monthly. For evaluation, the validated scale “Quantitative Global Grading System for Postacne Scarring” and patient's satisfaction were used before and 3 months after treatment. Optical coherence tomography imaging of the skin was used as an objective tool for assessment.ResultsBoth sides showed significant improvement on clinical evaluation with no significant difference. Optical coherence tomography assessment ...
BackgroundPsoriasis is a chronic inflammatory hyper proliferative skin disease. Angiogenesis play... more BackgroundPsoriasis is a chronic inflammatory hyper proliferative skin disease. Angiogenesis play an important role in Psoriasis pathogenesis, occurring even before plaque formation. Angiopoietins play an important role in angiogenesis and hence are described as angiogenic factors.AimsTo evaluate serum levels of angiopoeitin 2 (Ang‐2) following treatment with narrowband ultraviolet B (NBUVB) in patients with moderate‐severe plaque psoriasis and correlate it to psoriasis area and severity index (PASI).Patients/MethodsThis cross sectional study included 38 patients complaining of moderate to severe plaque psoriasis and 38 healthy controls. Psoriasis area and severity index (PASI) was determined and was correlated to serum levels of Ang‐2 before and after treatment with NBUVB.ResultsPASI scores and serum values of angiopoietin 2 demonstrated a significant difference between the baseline and at the end of the 12 weeks NBUVB treatment. A statistically significant positive correlation was...
Melasma is common skin condition presenting with hyperpigmentation. To evaluate the efficacy, tol... more Melasma is common skin condition presenting with hyperpigmentation. To evaluate the efficacy, tolerance, and complications of one session of combined chemical peels compared to traditional serial sessions of trichloroacetic acid (TCA) peeling in treating melasma. One session of combined chemical peels was carried out at the left side of the face, while six sessions of TCA 15% peel were carried out at the right side of the face every 10 days. The Modified Melasma Area and Severity Index (MASI) score was calculated at baseline (before starting peeling sessions), after one month (at the fourth TCA peeling session), and after three months (one month after the last TCA peeling session). Both sides of the face showed gradual reduction in modified MASI score throughout sessions. By the end of the study, the TCA-treated side showed slightly lower mean modified MASI score than the combined chemical peels-treated side of the face; however this difference was not statistically significant, (p=0.405). A single session of combined chemical peels is as effective as six sessions of TCA peel in treatment of melasma. Combined chemical peels can be used as a convenient, tolerable and time saving safe procedure for treating melasma.
Different skin presentations and patterns of cutaneous signs were reported in COVID19 patients. V... more Different skin presentations and patterns of cutaneous signs were reported in COVID19 patients. Varicella-zoster virus (VZV) infection is responsible for two very common skin conditions. Varicella (chickenpox) is the initial presentation for infection with VZV and is characterized by a diffuse vesicular rash. It is after this initial attack, that VZV remains latent in the dorsal root ganglia before reactivating to present as herpes zoster (HZ) in middle age groups. Cutaneous skin findings remain to be emerging every day as a marker or a complication of COVID 19. We report a case of HZ complication in a 44 years old COVID 19 positive male.
Striae distensae (SD) is a challenging skin condition. Striae alba (SA) represents the chronic la... more Striae distensae (SD) is a challenging skin condition. Striae alba (SA) represents the chronic late atrophic stage of SD. Fractional laser technology is among the modalities used for treating SD. Lately, fractional microneedling radiofrequency (FMR) is gaining increased popularity in treating SD. The aim of our study was to assess and compare the efficacy of FMR and fractional Er:YAG laser in the treatment of SA.
This document contains proprietary information, images and marks of Journal of Drugs in Dermatolo... more This document contains proprietary information, images and marks of Journal of Drugs in Dermatology (JDD). No reproduction or use of any portion of the contents of these materials may be made without the express written consent of JDD.
Acute phase reactants (APR) are proteins that had been associated with psoriasis severity. We aim... more Acute phase reactants (APR) are proteins that had been associated with psoriasis severity. We aimed to evaluate the association between psoriasis disease severity and some inflammatory markers as (CRP, ESR, and fibrinogen) before and after narrow band ultraviolet NB (NB‐UVB) therapy. The present study included 38 psoriatic patients and 38 controls of matching age and sex. The 38 included patients were divided according to their pretreatment PASI score into 2 subgroups: moderate 13 (34.2%) and severe 25 (65.8%). CRP, ESR, and fibrinogen levels were measured before and after NBUVB sessions for psoriatic patients and their levels were correlated to psoriasis area and severity index (PASI) improvements. PASI scores and laboratory values of APRs showed a significant difference before and after NBUVB sessions. PASI scores significantly correlated with CRP and FBG levels before and after treatment whereas no significant correlation was demonstrated between PASI and ESR levels before and after treatment. A combination of inflammatory markers and clinical assessment could be used in the formation of a new diagnostic tool to evaluate psoriasis severity and response to treatment.
Sphingolipids (SLs), are structural components of the skin that contribute to the regulation of t... more Sphingolipids (SLs), are structural components of the skin that contribute to the regulation of the proliferation and differentiation of keratinocytes as well as regulation of the skin epidermal barrier. A prospective cross sectional comparative controlled study was designed to evaluate the serum level of sphingosine 1 phosphate(S1P) and ceramide(CER) before and after narrow band ultraviolet B (NBUVB) in psoriatic patients. The study included 32 patients presented with psoriasis and 32 healthy age and sex matched control volunteers. (S1P and CER) levels were measured before and after NBUVB sessions for psoriatic patients and their levels were correlated to psoriasis area and severity index (PASI) improvements. PASI scores and serum values of the studied sphingolipids demonstrated a significant difference between the baseline and at the end of the 12 weeks NBUVB treatment. A statistically significant positive correlation was established between psoriasis severity and S1P serum levels before and after treatment while no correlation was observed between psoriasis severity and CER This article is protected by copyright. All rights reserved. serum levels. Decreased total CER and increased S1P serum levels reflect altered sphingolipid metabolism in psoriasis and can be predictors of disease severity.
The World Health Organization has recently defined the severe acute respiratory syndrome coronavi... more The World Health Organization has recently defined the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections as a pandemic. The infection, that may cause a potentially very severe respiratory disease, now called coronavirus disease 2019 (COVID-19), has airborne transmission via droplets while less attention focused on aerosol transmission. Surgical smoke and plumes in laser clinics represent a source for aerosol particles. The aim of this article is to provide the authors opinion for the correct use of "laser devices" in the COVID-19 emergency and to reduce potential risks of laser airborne contaminants.
Sexually transmitted infections (STIs) are group of diseases that are transmitted by vaginal, ana... more Sexually transmitted infections (STIs) are group of diseases that are transmitted by vaginal, anal or oral intercourse. They can be viral, bacterial, parasitic or protozoal infection. Every day more than one million STIs acquired (Ott & Santelli, 2019). Viral warts are benign growths that are caused by human papillomavirus (HPV) infection that infect skin and mucosa. HPV has more than 120 subtypes, and it is a double-stranded DNA virus. Genital warts commonly occur in perigenital areas and perianal areas, and they are usually asymptomatic. The occurring inflammation due to warts causes some sort of imbalance of oxidant versus antioxidant systems in tissues (Cokluk et al., 2015). Reactive oxygen species (ROS) as molecular oxygen (O 2), hydroxyl radicals (OH −), superoxide anion (O − 2) and hydrogen peroxide (H 2 O 2) in low levels participate in multiple cellular processes, such as cell differentiation cell proliferation, immune responses and apoptosis (Trouba, Hamadeh, Amin, & Germolec, 2002).
BackgroundApproaches to improve keloid scars include intralesional corticosteroid injections and ... more BackgroundApproaches to improve keloid scars include intralesional corticosteroid injections and fractional lasers exclusively. The combinative use of ablative fractional laser therapy and occluded topical corticosteroid as a drug delivery method enhances therapeutic outcome of two efficient scar therapy modules into one simple synergistic module.AimTo compare the therapeutic effect of combining two modalities of scar treatment, the first is fractional ablative laser treatment and the other is occluded topical corticosteroid to the standard use of intralesional steroid injection.MethodsKeloids from thirty suffering patients were split faced into two identical parts; one part received an intralesional corticosteroid injection while the other part was treated first with fractional ablative 2940 nm Er: YAG laser followed by occluded topical application of steroid cream. Four treatment sessions were performed with 4‐week interval between sessions. Every session was assessed photographic...
Various cutaneous manifestations have been observed in patients with COVID-19 infection. Herpes Z... more Various cutaneous manifestations have been observed in patients with COVID-19 infection. Herpes Zoster is a viral skin disease caused by varicella zoster that remains dormant in the dorsal root ganglia of cutaneous nerves following a primary chicken pox infection. In this report we describe two cases COVID infection who first presented with herpes zoster. We are here by suggesting that the clinical presentation of HZ at the time of the current pandemic even in patients giving mild or no suggestive history of upper respiratory symptoms should be considered as an alarming sign for a recent subclinical SARS CoV2 infection.
Journal of Blood Disorders & Transfusion, 2014
People living with HIV/AIDS in 2010 are around 34 million, already; more than 30 million people a... more People living with HIV/AIDS in 2010 are around 34 million, already; more than 30 million people around the world have died of AIDS-related diseases. In 2010, 2.7 million people were newly infected with HIV, and 1.8 million men, women and children died of AIDSrelated causes [9].
Sexually transmitted infections (STIs) are group of diseases that are transmitted by vaginal, ana... more Sexually transmitted infections (STIs) are group of diseases that are transmitted by vaginal, anal or oral intercourse. They can be viral, bacterial, parasitic or protozoal infection. Every day more than one million STIs acquired (Ott & Santelli, 2019). Viral warts are benign growths that are caused by human papillomavirus (HPV) infection that infect skin and mucosa. HPV has more than 120 subtypes, and it is a double-stranded DNA virus. Genital warts commonly occur in perigenital areas and perianal areas, and they are usually asymptomatic. The occurring inflammation due to warts causes some sort of imbalance of oxidant versus antioxidant systems in tissues (Cokluk et al., 2015). Reactive oxygen species (ROS) as molecular oxygen (O 2), hydroxyl radicals (OH −), superoxide anion (O − 2) and hydrogen peroxide (H 2 O 2) in low levels participate in multiple cellular processes, such as cell differentiation cell proliferation, immune responses and apoptosis (Trouba, Hamadeh, Amin, & Germolec, 2002).
Introduction and aim: Genital wart infection is a distressing sexually transmitted infection that... more Introduction and aim: Genital wart infection is a distressing sexually transmitted infection that causes marked fear and stress to both males and females. Tuberculin Purified protein derivative (PPD) injection is an upcoming safe and effective modality for the treatment of genital warts. Interleukin 17 (IL-17) was found to be lower in wart patients than controls. This study aimed at measurement of serum level of IL-17 in genital warts patients before and after PPD injection. Patients and methods: The study was carried out as case-control interventional study on 63 patients (37 males and 26 females) with genital warts attending Dermatology and Andrology Clinics, faculty of medicine, Suez Canal University hospitals. 50 controls were enrolled in the study. All patients have injected 10 tuberculin units of PPD intradermally in the mother or largest warts every 2 weeks till 6 sessions. Serum level of IL-17 was measured by Sandwich ELISA technique to all patients before and after PPD injection and to all control subjects. Results: The mean age of patients was 30.8 years, the mean duration of warts was 4.73 months, the mean number of warts was 9.76 warts and 14.3% of patients experienced side effects to PPD. (58.7%) of patients were completely recovered from warts. Mean serum IL-17 was 81.1 ± 64.2 pg/mL versus 118.9 ± 93.8 pg/mL in genital wart patients versus controls respectively (P &amp;amp;lt; 0.05) and 81.1 ± 64.2 pg/mL versus 107.1 ± 66.8 pg/mL before and after PPD injection respectively (P &amp;amp;lt; 0.05). Conclusion: IL-17 serum level was significantly lower in genital wart patients than normal controls. IL-17 serum level had been increased significantly after PPD intralesional injection than pretreatment levels and significantly related to clinical response to PPD. IL-17 suggested having a role in the clinical efficacy of PPD in the treatment of genital warts.
Background: Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering ... more Background: Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering and heterogeneity in the onset and progression indicate that susceptibility to CSU is a complex trait. In this study, we performed haplotype analysis for one of the key player gene, IL17RA, for CSU to test the association with disease susceptibility and severity. Methods The study included 70 CSU patients and 30 healthy controls. The severity of the disease was evaluated by autologous serum skin test (ASST) and urticaria activity score (UAS). ASST test was done and quality of life was assessed using a questionnaire. Allelic discrimination analysis for rs4819554 and rs879577 was performed using Real-Time Polymerase Chain Reaction technology. Results: Carriers of rs4819554*G were more prone to develop CSU than its counterpart (p = 0.039), while rs4819554*A allele displayed more severe phenotype in the form of more prolonged disease duration (p = 0.040), concurrent angioedema (p < 0.001), higher level of treatment (p < 0.001), and higher score of quality of life (p < 0.001). Additionally, homozygote patients with rs879577*CC were associated with angioedema (p < 0.001). Haplotype analysis revealed that cohorts with both rs4819554*A and rs879577*T conferred protection against developing CSU (OR = 0.07, 95%CI = 0.01-0.32, p = 0.001). Conclusions: Our results showed that IL17RA gene polymorphisms might contribute to the increased susceptibility to CSU. Biochemical analysis Liver function tests, complete blood count (CBC), erythrocyte sedimentation rate, a parasite stool test, and complete urine analysis were performed in the clinical pathology department laboratories. Allelic discrimination analysis by real-time PCR DNA extraction from blood leukocytes was done using QIAamp DNA Blood Mini kits (Qiagen, Clinilab Co., Egypt, Catalog no. 51104), according to the manufacturer's instructions. Genotyping of the promoter variant (rs4819554, c.-947G > A) and the missense mutation (rs879577, c.1100C > T; p.A367E or p. 367V) was performed using real-time polymerase chain reaction (RT-PCR) using TaqMan® genotyping assay (Applied Biosystem, assay ID C__337392_30 and C__2666446_20) as previously described [17]. Statistical analysis Statistical analysis was carried out using SPSS software, version 26.0. The test for normality was performed using the Shapiro-Wilk test. Descriptive statistics were represented as mean ± standard deviation (SD) for quantitative variables and percentages for qualitative variables. For qualitative variables, the Chi-square and Fisher's Exact tests were used. For quantitative variables, the student's t and Kruskal-Wallis tests were used for non-parametric variables. A p-value < 0.05 was considered statistically signi cant, and all statistical tests were two-sided.
Introduction: Sexual relationships are an integral part of females psychological and physiologica... more Introduction: Sexual relationships are an integral part of females psychological and physiological wellbeing. Objectives: The study aimed to identify prevalence and impact of Female Sexual Dysfunction (FSD) in women affected with psoriasis. Methods: This cross-sectional study was carried out on 150 married females who were interviewed to answer Female Sexual Function Index (FSFI) questionnaire and were divided into two groups: the first group included 100 female patients complaining of psoriasis (50 suffering from moderate psoriasis and 50 with severe psoriasis). The disease severity was graded according to the Psoriasis Area and Severity Index (PASI) while the second group included 50 age matched women who served as controls. Results: Female sexual dysfunction (FSD) in psoriasis female groups was higher than that in the control group (47%, 24%, P < 0.05). The mean total scores of FSFI ranged from 12.30 to 34.20 and were significantly lower in the severe PASI affected group (22.3...
Background: Anogenital warts are growths caused by human papilloma virus infection, which causes ... more Background: Anogenital warts are growths caused by human papilloma virus infection, which causes significant psychosocial morbidity. Intralesional immunotherapy is a promising treatment that is able to stimulate a delayed-type hypersensitivity reaction to different antigens as well as wart tissue. This treatment is suggested to increase CD4 T helper 1 lymphocyte activity to destroy human papilloma virus. Objective: To measure the level of serum soluble CD4 (sCD4) in patients with anogenital after intralesional tuberculin purified protein derivative (PPD) injection. Patients and Methods: This study was carried out as a pre-post interventional study on 49 patients with anogenital warts presented to the dermatology clinic and the andrology clinic, Suez Canal University Hospital. Each patient was injected 10U (0.2ml) of PPD intralesionally in the largest or mother wart with 2-week interval till complete cure or six injections, whichever was closer. Serum sCD4 was measured before and after injection using sandwich ELISA technique. Results: Complete clinical wart recovery was obtained in 26 (53%) patients and mostly was after the sixth session (60.4%) of injection. Mean level of serum sCD4 was significantly higher after than before PPD injection (18.47±10.4 vs. 44.48±20.67ng/ml, respectively). Serum sCD4 levels were significantly correlated to clinical response rates, as the higher the level of serum sCD4, the more the wart recovery. Conclusion: Intralesional PPD injection is a promising effective modality in the treatment of anogenital warts. CD4 cells may have a role in anogenital wart eradication by PPD injection and significantly related to clinical response rates.
ABSTRACTBackgroundEfficacy and safety of ablative fractional laser used for treatment of acne sca... more ABSTRACTBackgroundEfficacy and safety of ablative fractional laser used for treatment of acne scars have been described in several studies. Recently, microneedling radiofrequency treatment has been showing promising results with low risk of side effects and rapid healing time.ObjectiveTo study efficacy and safety of ablative fractional Er:YAG laser 2940 nm and microneedling radiofrequency for facial atrophic acne scar.Methods21 patients with atrophic postacne scars were randomized to MRF for one half of the face and laser for the other half. Four sessions were performed monthly. For evaluation, the validated scale “Quantitative Global Grading System for Postacne Scarring” and patient's satisfaction were used before and 3 months after treatment. Optical coherence tomography imaging of the skin was used as an objective tool for assessment.ResultsBoth sides showed significant improvement on clinical evaluation with no significant difference. Optical coherence tomography assessment ...
BackgroundPsoriasis is a chronic inflammatory hyper proliferative skin disease. Angiogenesis play... more BackgroundPsoriasis is a chronic inflammatory hyper proliferative skin disease. Angiogenesis play an important role in Psoriasis pathogenesis, occurring even before plaque formation. Angiopoietins play an important role in angiogenesis and hence are described as angiogenic factors.AimsTo evaluate serum levels of angiopoeitin 2 (Ang‐2) following treatment with narrowband ultraviolet B (NBUVB) in patients with moderate‐severe plaque psoriasis and correlate it to psoriasis area and severity index (PASI).Patients/MethodsThis cross sectional study included 38 patients complaining of moderate to severe plaque psoriasis and 38 healthy controls. Psoriasis area and severity index (PASI) was determined and was correlated to serum levels of Ang‐2 before and after treatment with NBUVB.ResultsPASI scores and serum values of angiopoietin 2 demonstrated a significant difference between the baseline and at the end of the 12 weeks NBUVB treatment. A statistically significant positive correlation was...
Melasma is common skin condition presenting with hyperpigmentation. To evaluate the efficacy, tol... more Melasma is common skin condition presenting with hyperpigmentation. To evaluate the efficacy, tolerance, and complications of one session of combined chemical peels compared to traditional serial sessions of trichloroacetic acid (TCA) peeling in treating melasma. One session of combined chemical peels was carried out at the left side of the face, while six sessions of TCA 15% peel were carried out at the right side of the face every 10 days. The Modified Melasma Area and Severity Index (MASI) score was calculated at baseline (before starting peeling sessions), after one month (at the fourth TCA peeling session), and after three months (one month after the last TCA peeling session). Both sides of the face showed gradual reduction in modified MASI score throughout sessions. By the end of the study, the TCA-treated side showed slightly lower mean modified MASI score than the combined chemical peels-treated side of the face; however this difference was not statistically significant, (p=0.405). A single session of combined chemical peels is as effective as six sessions of TCA peel in treatment of melasma. Combined chemical peels can be used as a convenient, tolerable and time saving safe procedure for treating melasma.
Different skin presentations and patterns of cutaneous signs were reported in COVID19 patients. V... more Different skin presentations and patterns of cutaneous signs were reported in COVID19 patients. Varicella-zoster virus (VZV) infection is responsible for two very common skin conditions. Varicella (chickenpox) is the initial presentation for infection with VZV and is characterized by a diffuse vesicular rash. It is after this initial attack, that VZV remains latent in the dorsal root ganglia before reactivating to present as herpes zoster (HZ) in middle age groups. Cutaneous skin findings remain to be emerging every day as a marker or a complication of COVID 19. We report a case of HZ complication in a 44 years old COVID 19 positive male.
Striae distensae (SD) is a challenging skin condition. Striae alba (SA) represents the chronic la... more Striae distensae (SD) is a challenging skin condition. Striae alba (SA) represents the chronic late atrophic stage of SD. Fractional laser technology is among the modalities used for treating SD. Lately, fractional microneedling radiofrequency (FMR) is gaining increased popularity in treating SD. The aim of our study was to assess and compare the efficacy of FMR and fractional Er:YAG laser in the treatment of SA.
This document contains proprietary information, images and marks of Journal of Drugs in Dermatolo... more This document contains proprietary information, images and marks of Journal of Drugs in Dermatology (JDD). No reproduction or use of any portion of the contents of these materials may be made without the express written consent of JDD.
Acute phase reactants (APR) are proteins that had been associated with psoriasis severity. We aim... more Acute phase reactants (APR) are proteins that had been associated with psoriasis severity. We aimed to evaluate the association between psoriasis disease severity and some inflammatory markers as (CRP, ESR, and fibrinogen) before and after narrow band ultraviolet NB (NB‐UVB) therapy. The present study included 38 psoriatic patients and 38 controls of matching age and sex. The 38 included patients were divided according to their pretreatment PASI score into 2 subgroups: moderate 13 (34.2%) and severe 25 (65.8%). CRP, ESR, and fibrinogen levels were measured before and after NBUVB sessions for psoriatic patients and their levels were correlated to psoriasis area and severity index (PASI) improvements. PASI scores and laboratory values of APRs showed a significant difference before and after NBUVB sessions. PASI scores significantly correlated with CRP and FBG levels before and after treatment whereas no significant correlation was demonstrated between PASI and ESR levels before and after treatment. A combination of inflammatory markers and clinical assessment could be used in the formation of a new diagnostic tool to evaluate psoriasis severity and response to treatment.
Sphingolipids (SLs), are structural components of the skin that contribute to the regulation of t... more Sphingolipids (SLs), are structural components of the skin that contribute to the regulation of the proliferation and differentiation of keratinocytes as well as regulation of the skin epidermal barrier. A prospective cross sectional comparative controlled study was designed to evaluate the serum level of sphingosine 1 phosphate(S1P) and ceramide(CER) before and after narrow band ultraviolet B (NBUVB) in psoriatic patients. The study included 32 patients presented with psoriasis and 32 healthy age and sex matched control volunteers. (S1P and CER) levels were measured before and after NBUVB sessions for psoriatic patients and their levels were correlated to psoriasis area and severity index (PASI) improvements. PASI scores and serum values of the studied sphingolipids demonstrated a significant difference between the baseline and at the end of the 12 weeks NBUVB treatment. A statistically significant positive correlation was established between psoriasis severity and S1P serum levels before and after treatment while no correlation was observed between psoriasis severity and CER This article is protected by copyright. All rights reserved. serum levels. Decreased total CER and increased S1P serum levels reflect altered sphingolipid metabolism in psoriasis and can be predictors of disease severity.
The World Health Organization has recently defined the severe acute respiratory syndrome coronavi... more The World Health Organization has recently defined the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections as a pandemic. The infection, that may cause a potentially very severe respiratory disease, now called coronavirus disease 2019 (COVID-19), has airborne transmission via droplets while less attention focused on aerosol transmission. Surgical smoke and plumes in laser clinics represent a source for aerosol particles. The aim of this article is to provide the authors opinion for the correct use of "laser devices" in the COVID-19 emergency and to reduce potential risks of laser airborne contaminants.
Sexually transmitted infections (STIs) are group of diseases that are transmitted by vaginal, ana... more Sexually transmitted infections (STIs) are group of diseases that are transmitted by vaginal, anal or oral intercourse. They can be viral, bacterial, parasitic or protozoal infection. Every day more than one million STIs acquired (Ott & Santelli, 2019). Viral warts are benign growths that are caused by human papillomavirus (HPV) infection that infect skin and mucosa. HPV has more than 120 subtypes, and it is a double-stranded DNA virus. Genital warts commonly occur in perigenital areas and perianal areas, and they are usually asymptomatic. The occurring inflammation due to warts causes some sort of imbalance of oxidant versus antioxidant systems in tissues (Cokluk et al., 2015). Reactive oxygen species (ROS) as molecular oxygen (O 2), hydroxyl radicals (OH −), superoxide anion (O − 2) and hydrogen peroxide (H 2 O 2) in low levels participate in multiple cellular processes, such as cell differentiation cell proliferation, immune responses and apoptosis (Trouba, Hamadeh, Amin, & Germolec, 2002).
BackgroundApproaches to improve keloid scars include intralesional corticosteroid injections and ... more BackgroundApproaches to improve keloid scars include intralesional corticosteroid injections and fractional lasers exclusively. The combinative use of ablative fractional laser therapy and occluded topical corticosteroid as a drug delivery method enhances therapeutic outcome of two efficient scar therapy modules into one simple synergistic module.AimTo compare the therapeutic effect of combining two modalities of scar treatment, the first is fractional ablative laser treatment and the other is occluded topical corticosteroid to the standard use of intralesional steroid injection.MethodsKeloids from thirty suffering patients were split faced into two identical parts; one part received an intralesional corticosteroid injection while the other part was treated first with fractional ablative 2940 nm Er: YAG laser followed by occluded topical application of steroid cream. Four treatment sessions were performed with 4‐week interval between sessions. Every session was assessed photographic...
Various cutaneous manifestations have been observed in patients with COVID-19 infection. Herpes Z... more Various cutaneous manifestations have been observed in patients with COVID-19 infection. Herpes Zoster is a viral skin disease caused by varicella zoster that remains dormant in the dorsal root ganglia of cutaneous nerves following a primary chicken pox infection. In this report we describe two cases COVID infection who first presented with herpes zoster. We are here by suggesting that the clinical presentation of HZ at the time of the current pandemic even in patients giving mild or no suggestive history of upper respiratory symptoms should be considered as an alarming sign for a recent subclinical SARS CoV2 infection.
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