Papers by Matthew Hoptman
Frontiers in psychiatry, Jun 26, 2024
Biological Psychiatry, May 1, 2022
Biological Psychiatry, May 1, 2021
Schizophrenia Bulletin, Apr 1, 2018
PLINK-v1.06 was used for the tabulation of possible individual haplotype phases and for the famil... more PLINK-v1.06 was used for the tabulation of possible individual haplotype phases and for the family-based association analyses (Transmission Disequilibrium Test). To explore the brain functional correlates of NRN1, the subjects belonging to case-control sample underwent a single MRI scanning session and performed a virtual reality spatial navigation task (Salgado-Pineda et al. 2016). The standard atlas provided in the FSL package was used to define three separate ROIs (left and right hippocampus and medial frontal region (mPFC)) and the mean value of activation per each subject was used to test the effect of each SNP/haplotypes by means of a linear regression. All the analyses were adjusted by age, sex and premorbid intelligence coefficient (IQ-TAP). Results: Two haplotypes including SNP4 and SNP5 (rs645649-rs582262) were associated with early onset SZ-SD: the haplotype CG was undertransmitted from parents to patients (p=0.011, OR (95%CI=0.08(0.01-0.71)protective haplotype), while the haplotype GG showed an overtransmission trend (p=0.055, OR (95%CI=3.83 (1.40-10.48)). No effect was observed in the adult onset subsample. No differences between patients and controls were observed in the activation of the three ROIs. Within patients, an effect of the haplotype CG (SNP4-5) was detected in the mPFC: carriers of no copies of the protective haplotype showed a higher mean activation (n=15, mean(SD)=-1.17(17.37)) than individuals with at least one copy of the haplotype (n=9, mean(SD)=-21.19(21.94)) (⎕=-0.507 p=0.035). Discussion: First, our family-based results are consistent with evidence of a genetic association between NRN1 gene and SZ-SD and extend the knowledge on that NRN1 has a selective impact on early age at onset (Fatjó-Vilas et al. 2016). Second, our data suggest that NRN1 is involved in the regulation of the de-activation of mPFC in patients with SZ during a spatial navigation task. This result is of special interest since mPFC is an area included in the Default Mode Network (DMN) and alterations in this network have been highly documented in SZ patients during performance of different tasks (
Schizophrenia Research, Jun 1, 2008
Biological Psychiatry, May 1, 1995
Biological Psychiatry, May 1, 2022
Brain Sciences, Mar 16, 2022
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Journal of Affective Disorders, Mar 1, 2021
BACKGROUND Depression affects many children and adolescents, leading to poor academic performance... more BACKGROUND Depression affects many children and adolescents, leading to poor academic performance, impaired psychosocial functioning, and an increased frequency of suicidal behavior. Depression has also been notably associated with trauma and distress tolerance. Our study sought to understand the relationships of these variables across age and sex categories in youth and adolescents. METHODS The current study examined data from a total of 324 participants between the ages of 7 and 17 years-old who were a part of a larger study. Data related to age, sex, depression, trauma, and distress tolerance were examined. RESULTS A multiple regression revealed a significant interaction between age and sex on depression severity. Further, trauma and age by sex categories significantly predicted depression score, as well as distress tolerance predicting depression score. Lastly, a regression analysis, including trauma, distress tolerance, and age by sex categories were significant predictors of depression. LIMITATIONS The results are limited by the cross-sectional design. CONCLUSION Clinicians should consider age by sex effects when treating childhood depression. Future research should further the understanding of depression across age and sex groups, as well as among children with extensive trauma experiences. Future research should also seek to further understand the implications of distress tolerance therapy on childhood depression.
Brain Injury, Apr 24, 2019
Background and Objective: Changes in cerebral white matter organization have been documented in a... more Background and Objective: Changes in cerebral white matter organization have been documented in acute phases of recovery from traumatic brain injury (TBI). However, little is known about reorganization processes in more chronic stages of recovery. The current study identified changes in white matter organization in chronic cases of TBI, and determined the relationship between structural changes and cognitive functioning. Methods: 15 adults with moderate to severe TBI and eight healthy controls completed neuropsychological testing and diffusion tensor imaging (DTI) scanning. Participants returned 3 years from the initial session to complete identical neuropsychological tests and scans. Results: Adults with TBI were found to have significantly reduced fractional anisotropy (FA), a metric of white matter organization, compared to healthy participants at baseline and also at 3-year follow-up. Within the sample of adults with TBI, increases in FA were observed over time. Importantly, increases in FA in the TBI sample were also correlated with improvements in cognitive performance. Conclusions: This study provides evidence of a dynamic process of white matter change occurring beyond the initial phases of recovery after moderate to severe TBI. The observed relationship between structural reorganization and changes in cognitive performance has implications for rehabilitation potential in more chronic phases of recovery.
Current Behavioral Neuroscience Reports, Jul 4, 2016
Impulsivity is elevated in schizophrenia and is a risk factor for aggression in the disorder, but... more Impulsivity is elevated in schizophrenia and is a risk factor for aggression in the disorder, but it is a multidimensional construct. Recently, the impulsivity subconstruct of urgency, which refers to rash action in the face of strong mood states, has been shown to be highly correlated with aggression in schizophrenia, especially impulsive aggression. This review discusses recent neuroimaging findings regarding urgency and its relation to impulsive aggression in schizophrenia. In addition, potential relationships between urgency and emotional regulation are discussed, along with potential treatments for impulsive aggression in schizophrenia that could be developed via a consideration of the urgency construct.
CNS spectrums, Apr 22, 2015
Elevations of impulsive behavior have been observed in a number of serious mental illnesses. Thes... more Elevations of impulsive behavior have been observed in a number of serious mental illnesses. These phenomena can lead to harmful behaviors, including violence, and thus represent a serious public health concern. Such violence is often a reason for psychiatric hospitalization, and it often leads to prolonged hospital stays, suffering by patients and their victims, and increased stigmatization. Despite the attention paid to violence, little is understood about its neural basis in schizophrenia. On a psychological level, aggression in schizophrenia has been primarily attributed to psychotic symptoms, desires for instrumental gain, or impulsive responses to perceived personal slights. Often multiple attributions can coexist during a single aggressive incident. In this review, I will discuss the neural circuitry associated with impulsivity and aggression in schizophrenia, with an emphasis on implications for treatment. Impulsivity appears to account for a great deal of aggression in schizophrenia, especially in inpatient settings. Urgency, defined as impulsivity in the context of strong emotion, is the primary focus of this article. It is elevated in several psychiatric disorders, and in schizophrenia, it has been related to aggression. Many studies have implicated dysfunctional frontotemporal circuitry in impulsivity and aggression in schizophrenia, and pharmacological treatments may act via that circuitry to reduce urgency and aggressive behaviors, but more mechanistic studies are critically needed. Recent studies point toward manipulable neurobehavioral targets and suggest that cognitive, pharmacological, neuromodulatory, and neurofeedback treatment approaches can be developed to ameliorate urgency and aggression in schizophrenia. It is hoped that these approaches will improve treatment efficacy.
The Journal of Sexual Medicine, May 1, 2023
Introduction Uncertainty remains about the psychological and sexual implications of gender role n... more Introduction Uncertainty remains about the psychological and sexual implications of gender role nonconformity (GRNC), generally defined as men endorsing or performing femininity, and women endorsing or performing masculinity. Previous studies have demonstrated that variance in gender presentation is associated with negative psychological consequences. Homophobic stigmatization and internalized homophobia partially mediate this association, suggesting it is not the practice of GRNC that causes distress, but internal or external reactions to it. Objective Here, we test the hypothesis that people reporting higher levels of GRNC will have more sexual dysfunction, and that social support will mediate this relationship. Methods We analyzed data from the Nathan Kline Institute Rockland Sample. The sample we selected includes 781 subjects (age= 48.99 ± 17.42, sex= 67% female). All subjects completed the Sex Role Identity Scale (SRIS) and the Trauma Symptom Checklist (TSC-40). GRNC was quantified by SRIS questions-subjective GRNC was assessed using the question “How feminine/masculine do you think you are?”, behavioral GRNC was assessed with “How feminine/masculine do you act or behave?”, and perceived GRNC with “How feminine/masculine do you think you appear and come across to others?” A composite variable was created to assess overall GRNC. Sexual dysfunction was measured with the relevant TSC-40 subscale. Because the distribution of GRNC scores were not normally distributed, we performed a quantile regression analysis using the quantreg and mediation packages in R to understand the mediation effect of social support on the relationship between GRNC and sexual dysfunction, while controlling for sex, age, sexual orientation, and socioeconomic status. Results In the quantile regression model, GRNC significantly predicted sexual dysfunction (β = 0.86, 95%CI [0.52, 1.20]) and social support significantly predicted sexual dysfunction (β = -3.63, 95%CI [-4.30, -2.42]). In the mediation analysis, there was a significant mediation effect of social support on the relationship between GRNC and sexual dysfunction (β = 0.17, 95%CI [0.04, 0.31], p<0.001), controlling for sex, age, sexual orientation, and socioeconomic status. The mediation effect accounted for 16.56% (95%CI [0.05-0.28], p<0.001) of the variance in sexual dysfunction. Conclusions GRNC significantly predicts sexual dysfunction, and social support significantly mediates this relationship, accounting for a substantial percentage of its variance. These results suggest that although GRNC can be associated with negative psychological and sexual consequences, the impacts are significantly mediated by the quality and strength of social relationships. This supports previous literature suggesting that negative reactions to nonconformity, both personal and systemic, may account for decreased well-being in people exhibiting GRNC. Although the findings are limited by the nature of secondary analyses, these results highlight the clinical significance of understanding GRNC to better treat patients with sexual dysfunction and promote healthy sexual functioning for all individuals. Disclosure No
Biological Psychiatry, May 1, 2023
Biological Psychiatry, May 1, 2023
Biological Psychiatry, May 1, 2023
Series in computer vision, Nov 14, 2013
Geriatric depression consists of complex and heterogeneous behaviors unlikely to be caused by a s... more Geriatric depression consists of complex and heterogeneous behaviors unlikely to be caused by a single brain lesion. However, there is evidence that abnormalities in specific brain structures and their interconnections confer vulnerability to the development of late-life depression. Structural magnetic resonance imaging methods can be used to identify and quantify brain abnormalities predisposing to geriatric depression and in prediction of treatment response. This article reviews several techniques, including morphometric approaches, study of white matter hyperintensities, diffusion tensor imaging, magnetization transfer imaging, t2 relaxography, and spectroscopy, that have been used to examine these brain abnormalities with a focus on the type of information obtained by each method as well as each method's limitations. The authors argue that the available methods provide complementary information and that, when combined judiciously, can increase the knowledge gained from neuroimaging findings and conceptually advance the field of geriatric depression.
Biological Psychiatry, May 1, 2018
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Papers by Matthew Hoptman