Papers by Naznin Sultana, PhD, CEng, Csci
Colloids and Surfaces A: Physicochemical and Engineering Aspects
Malaysian Journal of Fundamental and Applied Sciences
In recent decades, tissue engineering has emerged as an alternative solution to improve the quali... more In recent decades, tissue engineering has emerged as an alternative solution to improve the quality of life for patients who suffer from diseases involving loss of tissues. The development of a biocompatible tissue engineering scaffold using nanofibrous membrane has garnered increasing interest in biomedical applications due to its similarity of structural property to the extracellular matrix, which is essential for cell growth. Thus, this study was conducted to fabricate a nanofibrous membrane with small diameter structure using a polymer blend of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(lactic-co-glycolic acid) (PLGA) and through the electrospinning technique, and to evaluate its biocompatibility with fibroblast cells. The nanofibrous structure was optimized using three different ratios (25:75; 50:50; 75:25) of PHBV/PLGA polymer. Characterization of the nanofibrous membrane was done using a scanning electron microscope (SEM), attenuated total reflection - Fouri...
Journal of Applied Membrane Science & Technology
Using biodegradable polymer polycaprolactone (PCL) and zeolite, the present experiment was conduc... more Using biodegradable polymer polycaprolactone (PCL) and zeolite, the present experiment was conducted with the aim of using biodegradable PCL and zeolite based composite membrane to remove silver in drinking water. After optimizing the electrospinning parameters, a double-layered PCL and PCL/zeolite electrospun composite membranes were manufactured. The membranes were then characterized using a scanning electron microscope (SEM) and an energy dispersive X-ray (EDX) and the filtration phenomenon was conducted by dispersing silver nanoparticles in water. After comparing the filtration results using an inductively coupled plasma optical emission spectrometry (ICP-OES), it was observed that the bi-layered membrane filtered 90% of silver present in the water. The present work shows that the new PCL/zeolite based double-layered membrane can be promising to remove contaminants in drinking water.
Asian Journal of Advances in Agricultural Research
This experiment was conducted to evaluate the effect of chitosan coating on physiological respons... more This experiment was conducted to evaluate the effect of chitosan coating on physiological responses and nutritional qualities of tomato fruits at postharvest storage. There were four treatments of chitosan viz. T0 (control), T1 (0.10%), T2 (0.20%) and T3 (0.30%), and two storage conditions viz. in refrigerator (4°C) and room temperature (≈23-25°C). The matured light yellow tomato fruit samples were collected at 10, 20, 30 and 50 days after postharvest storage to assess physiological parameters viz. shelf life and weight loss as well as to determine lycopene and mineral constituents viz. Ca, Mg, P, S, Na and K. The mean weight loss of tomato fruits were 0.64, 1.28, 1.59 and 2.28% at 4°C, while it was 0.88, 1.84, 2.60 and 4.80% at room temperature at 10, 20, 30 and 50 days after postharvest storage, respectively. The shelf life of tomato fruits ranged between 58.3-100.0, 50.0-100.0, 33.3-75.0 and 16.7-66.8% at 4°C, while the ranges were 66.8-100.0, 50.0-100.0, 33.3-75.0 and 0.0-41.8% ...
Journal of Applied Membrane Science & Technology
Recently, in the field of tissue engineering, fabrication of three-dimensional (3D) electrospun s... more Recently, in the field of tissue engineering, fabrication of three-dimensional (3D) electrospun scaffold or membrane is much emphasized. In this study, layered composite scaffolds or membranes were fabricated using two biodegradable polymers, polycaprolactone (PCL) and Chitosan layer-by-layer with multilayer electrospinning method. Characterizations of membranes were done using several techniques. Electrospun composite membrane’s surface morphology was examined using a Scanning Electron Microscopy (SEM) and the wettability of the material’s surface was determined using water contact angle measuring measurement (WCA). Water uptake properties of electrospun membrane were also determined. Using optimized solution concentration and electrospinning processing parameters, the composite PCL/Chitosan and PCL layer-by-layer were successfully fabricated. It was observed from SEM that the composite electrospun membranes produced consisted microfibers and nanofibers within single scaffold. The ...
Cytotechnology, Jan 30, 2017
Growing three dimensional (3D) cells is an emerging research in tissue engineering. Biophysical p... more Growing three dimensional (3D) cells is an emerging research in tissue engineering. Biophysical properties of the 3D cells regulate the cells growth, drug diffusion dynamics and gene expressions. Scaffold based or scaffoldless techniques for 3D cell cultures are rarely being compared in terms of the physical features of the microtissues produced. The biophysical properties of the microtissues cultured using scaffold based microencapsulation by flicking and scaffoldless liquid crystal (LC) based techniques were characterized. Flicking technique produced high yield and highly reproducible microtissues of keratinocyte cell lines in alginate microcapsules at approximately 350 ± 12 pieces per culture. However, microtissues grown on the LC substrates yielded at lower quantity of 58 ± 21 pieces per culture. The sizes of the microtissues produced using alginate microcapsules and LC substrates were 250 ± 25 μm and 141 ± 70 μm, respectively. In both techniques, cells remodeled into microtissu...
3 Biotech
Considering the important factor of bioactive nanohydoxyapatite (nHA) to enhance osteoconductivit... more Considering the important factor of bioactive nanohydoxyapatite (nHA) to enhance osteoconductivity or bone-bonding capacity, nHA was incorporated into an electrospun polycaprolactone (PCL) membrane using electrospinning techniques. The viscosity of the PCL and nHA/PCL with different concentrations of nHA was measured and the morphology of the electrospun membranes was compared using a field emission scanning electron microscopy. The water contact angle of the nanofiber determined the wettability of the membranes of different concentrations. The surface roughness of the electrospun nanofibers fabricated from pure PCL and nHA/PCL was determined and compared using atomic force microscopy. Attenuated total reflectance Fourier transform infrared spectroscopy was used to study the chemical bonding of the composite electrospun nanofibers. Beadless nanofibers were achieved after the incorporation of nHA with a diameter of 200–700 nm. Results showed that the fiber diameter and the surface ro...
ASAIO Journal
Conductive materials are potential candidates for developing bone tissue engineering scaffolds as... more Conductive materials are potential candidates for developing bone tissue engineering scaffolds as they are nontoxic and can enhance bone tissue regeneration. Their bioactivity can be enhanced by depositing biomineralization in simulated body fluid (SBF). In the current study, a composite electrospun membrane made up of poly(lactic) acid, poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and hydroxyapatite was fabricated using an electrospinning method. The fabricated membranes were dip-coated with a conductive polymer solution, poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate), to induce conductivity. Characterization of the membranes based on characteristics such as morphology, chemical bonding, and wettability was conducted using scanning electron microscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, attenuated total reflectance Fourier transform infrared spectroscopy, and contact angle measurement. From the results, biomineralization of both coated and noncoated composite membranes was observed on the surface of nanofibers after 21 days in SBF. The membranes provide a superhydrophilic surface as shown by the contact angle. In conclusion, this biomimetic electrospun composite membrane could be used to further support cell growth for bone tissue engineering application.
2014 IEEE Conference on Biomedical Engineering and Sciences (IECBES), 2014
2014 IEEE Conference on Biomedical Engineering and Sciences (IECBES), 2014
Publikationsansicht. 56162737. Fabrication of PHBV and PHBV-based composite tissue engineering sc... more Publikationsansicht. 56162737. Fabrication of PHBV and PHBV-based composite tissue engineering scaffolds through the emulsion freezing/freeze-drying process and evaluation of the scaffolds (2009). Sultana, Naznin. Abstract. Thesis (Ph. D.)--University of Hong Kong, 2010.. ...
Journal of Nanomaterials, 2012
Advanced Materials Research, Nov 19, 2014
International Journal of Pharmacology, 2012
2015 10th Asian Control Conference (ASCC), 2015
Applied Mechanics and Materials, 2014
Scaffold provides a suitable medium for cell growing and drug delivery while enhancing the cell t... more Scaffold provides a suitable medium for cell growing and drug delivery while enhancing the cell transplantation efficiency. In this project, nanofibrous scaffolds were fabricated through electrospinning of Polycaprolactone (PCL) and Gelatin (GE). Processing parameters and solution parameters were optimized to achieve the desired properties of PCL/GE nanofibers. Scanning Electron Microscopy (SEM), water contact angle and Attenuated Total Reflectance–Fourier Transformed Infrared Spectroscopy (ATR-FTIR) were implemented to characterize the fabricated nanofibers. It was found that 14% w/v PCL/GE shows the best fibers’ diameter, pore size, contact angle and less bead formation. This sample is suitable to be further investigated for the application of tissue engineering (TE) and drug delivery system (DDS).
Applied Mechanics and Materials, 2014
Tissue engineering is the promising technique to replace organ transplant in order to solve many ... more Tissue engineering is the promising technique to replace organ transplant in order to solve many problems regarding the shortage of organ donor and other problems related to organ or tissue transplantation such as bleeding, diseases, accidents and others. Polycaprolactone (PCL) and chitosan (Cs) are biodegradable polymers that have the properties to develop into scaffold. Both of the polymers were used in this research in order to produce scaffold by using freeze drying technique. Four samples of scaffolds were fabricated with the variety of concentration chitosan, PCL 10% (1g of PCL in 10ml glacial acetic acid), PCL/Cs 11% (1g of PCL and 0.1g of chitosan in 10ml glacial acetic acid), PCL/Cs 12% (1g of PCL and 0.2g of chitosan in 10ml glacial acetic acid) and also PCL/Cs 13% (1g of PCL and 0.3g of chitosan in 10ml glacial acetic acid). The produced scaffolds had good properties from both polymers such as faster degradation rate, hydrophilic, porous and others.
Applied Mechanics and Materials, 2014
Tissue engineering (TE) provides an alternative option to solve limitation of organ and tissue tr... more Tissue engineering (TE) provides an alternative option to solve limitation of organ and tissue transplantation issues. Fabrication of scaffold is a major challenge because it needs to provide a suitable medium for cell growing and drug delivery which enhances cell transplantation efficiency. The porosity, biodegradability and biocompatibility are the important properties in fabricating a scaffold. Our previous work had found that electrospinning of Polycarprolactone (PCL)/ Gelatin (GE)-based nanofibers in 14% w/v polymer solution in 18kV showed the best results in morphology, average diameters, average pore size and hydrophilicity. Hence, in this project, we are interested to study the relationship between weight ratio of PCL and GE in the same concentration (14%) to the morphology, degradation rate and porosity of nanofibers. Experimental results showed that PCL with 1.2g and GE with 0.2g was able to produce better nanofibers. The sample was then further deployed in drug (tetracycl...
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Papers by Naznin Sultana, PhD, CEng, Csci