Papers by Ayorinde Folasire
Annals of Oncology, Sep 30, 2023
Ecancermedicalscience, Oct 1, 2023
Cancer Research, Mar 1, 2023
Journal of Clinical Oncology, Jun 1, 2022
Cancer Control
Introduction Prostate cancer is the most common cancer in men. It was initially a disease of olde... more Introduction Prostate cancer is the most common cancer in men. It was initially a disease of older men above the age of 55 years. Of recent, there has been reports of increase in the number of young men <55 years with prostate cancer (PCa). The disease in this age group has been reported to be more lethal because of aggressive characteristics and metastatic potential. Different populations have different proportions of young-onset PCa. The aim of this study was to determine the proportion of young men aged <55 years with PCa in Nigeria. Methods Data on the prevalence of young men <55 years with PCa was extracted from the 2022 report of the prevalence of cancer in Nigeria from 2009 to 2016 based on the records of 15 major Cancer Registries in Nigeria. This was a publication of the Nigerian Ministry of Health and represents the most up to date data. Results In 4864 men diagnosed with malignancies before age 55, PCa was the second common, following liver cancer. Out of a total...
African journal of medicine and medical sciences, 2014
BACKGROUND Treatment interruption is the failure to execute approved treatment plan of a patient.... more BACKGROUND Treatment interruption is the failure to execute approved treatment plan of a patient. This adversely affects treatment outcomeif not properly managed. This retrospective study causes and management of radiation treatment interruptions during High Dose Rate Brachytherapy(HDRB) for carcinoma of the cervix in a teaching hospital in Nigeria. METHODS Five hundred patients with cervical carcinoma, who received HDRB, post external beam radiotherapy, between August, 2008 and July, 2013 were assessed. They were grouped into (A): those who experienced treatment interruption and (B): those who did not. Each patient was scheduled to receive three fractions of HDRB over 3 weeks. Those in groups A were assessed for the exact treatment fraction missed, the cause and duration of treatment interruption and the actions taken to compensate for non-execution of treatment. RESULTS A total of 90 patients fall into group A and most (41) of them experienced interruptions in the third fraction o...
Cancer Research, Mar 1, 2023
African Journal of Biomedical Research, Aug 1, 2015
Prostate cancer is the second most common non cutaneous male malignancy worldwide. Gleason compos... more Prostate cancer is the second most common non cutaneous male malignancy worldwide. Gleason composite score is used for risk classification. The most common site of metastasis in prostate cancer is the bone among others. The site and number of metastasis affect overall survival. The ability to predict the metastatic site at diagnosis can assist in predicting the prognosis. To assess the pattern of bone and visceral organ metastases in prostate cancer and evaluate if the initial Gleason grade at diagnosis can predict metastatic sites in prostate cancer. Records of patients with metastatic prostate cancer seen in an institution in Nigeria were analysed. Imaging examination reports used were Technitium99m bone scan for skeletal metastasis, ultrasonography, chest x-ray and cranial CT scan for evidence of visceral metastasis. The association of the initial Gleason grade and site of metastasis was determined using Chi square test for significance. Eighty two patient's records were analysed. The proportion of patients with low risk Gleason grade (≤6) at diagnosis was 27(32%), Intermediate risk grade (Gleason=7) was 25 (30%) while high risk Gleason grade (8-10) was 30 (38%). Spinal metastasis was 77(94%), pelvis 55(67%) femur 36 (44%) and tibia 1 (1%) while 55(67%) patients had multiple bones affected. Twenty seven patients 33% had visceral metastasis with liver 15(18%) lungs 9 (11%) and brain 3 (4%). There was no significant association between the initial Gleason risk grade with the site of metastasis (x 2 3 =2.411, p=0.491). The spine was the most common site of metastases from prostate cancer in this series. The Gleason risk grade at diagnosis was not predictive of metastatic site.
Medical journal of Zambia, 2018
Annals of Ibadan Postgraduate Medicine, 2019
CASE PRESENTATION An 85-year-old woman presented to us with nodular masses of various sizes on bo... more CASE PRESENTATION An 85-year-old woman presented to us with nodular masses of various sizes on both palms and ulcerated bleeding nodule on her right thumb [Fig. 1]. Four months earlier she had been diagnosed with invasive squamous cell carcinoma of cervix. The histologic diagnosis of the cervical carcinoma was that of a poorly differentiated squamous cell carcinoma. A CT scan of the abdomen, showed multiple noncalcified BILATERAL, NON-BONY METASTASES TO THE HAND FROM CERVICAL CARCINOMA
African Journal of Biomedical Research, 2015
Prostate cancer is the second most common non cutaneous male malignancy worldwide. Gleason compos... more Prostate cancer is the second most common non cutaneous male malignancy worldwide. Gleason composite score is used for risk classification. The most common site of metastasis in prostate cancer is the bone among others. The site and number of metastasis affect overall survival. The ability to predict the metastatic site at diagnosis can assist in predicting the prognosis. To assess the pattern of bone and visceral organ metastases in prostate cancer and evaluate if the initial Gleason grade at diagnosis can predict metastatic sites in prostate cancer. Records of patients with metastatic prostate cancer seen in an institution in Nigeria were analysed. Imaging examination reports used were Technitium99m bone scan for skeletal metastasis, ultrasonography, chest x-ray and cranial CT scan for evidence of visceral metastasis. The association of the initial Gleason grade and site of metastasis was determined using Chi square test for significance. Eighty two patient’s records were analysed...
Journal of Radiation Medicine in the Tropics
Journal of Nanomedicine & Biotherapeutic Discovery, 2020
Background: There is high mortality from prostate cancer in Nigeria. Lack of awareness and low sc... more Background: There is high mortality from prostate cancer in Nigeria. Lack of awareness and low screening uptake are associated with this poor outlook. There is need to develop strategies to improve uptake of screening to ensure early diagnosis for men with prostate cancer in our environment. Objectives: The objective of the study was to determine the proportion of men with initial PSA values ≥ 2.5-4 ng/mL who will be eligible for yearly follow up screening in high-risk prostate cancer population. Methods: This was a cross sectional study carried out among men from two worship centres in Ibadan Nigeria (A church and a mosque). Participants were educated on prostate cancer and the characteristics of PSA based screening before consent was obtained from individuals for participation. Self-administered questionnaires were completed before blood samples were obtained for PSA analysis. Digital rectal examinations were carried out among participants. Findings: All the 97 participants aged between 40 to 72 years who turned up for the exercise gave consent to participate. Complete data was available for 81 participants included in the final analysis. Five (6.25%) out of the 81 participants analyzed heard about prostate cancer and PSA testing but none has ever undergone PSA based screening. Total PSA values ranged from 0.064 ng/mL to 41.427 ng/mL with one outlier having a value of >100 ng/mL. Sixty-nine (86.25%) participants had PSA values < 2.5 ng/mL, 7 (8.75%) had values ≥ 2.5-4 ng/mL while 4(5%) had values greater than 4 ng/mL. Conclusion: Low number of participants (9%) had PSA values ≥ 2.5-4 mg/ml requiring yearly follow up screening. Sorting of men based on initial PSA results can reduce the number of those for yearly screening leading to the reduction in the burden associated with PSA based screening.
Journal of basic and clinical physiology and pharmacology, Jan 9, 2017
The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because of the m... more The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because of the myriad of toxic sequelae associated with it. The aim of this study was to assess the protective effects of gallic acid (GA) on DOX-induced cardiac toxicity in rats. Sixty male rats (Wistar strain) were used in this study. They were divided into six groups (A-F) each containing 10 animals. Group A was the control. Rats in Groups B, C, and D were treated with DOX at the dosage of 15 mg/kg body weight i.p. Prior to this treatment, rats in Groups C and D had been treated orally with GA for 7 days at the dosage of 60 and 120 mg/kg, respectively. Animals from Groups E and F received only 60 and 120 mg/kg GA, respectively, which were administered orally for 7 days. The exposure of rats to DOX led to a significant (p<0.05) decrease in the cardiac antioxidant defence system and elevation of creatine kinase myocardial band and lactate dehydrogenase. The electrocardiography results showed a signi...
South African Journal of Clinical Nutrition, 2016
This study assessed the nutrition-related cancer prevention knowledge and dietary pattern of unde... more This study assessed the nutrition-related cancer prevention knowledge and dietary pattern of undergraduate students. Design: A cross-sectional study design was employed.
Internal Medicine: Open Access, 2013
Journal of Clinical Oncology
TPS622 Background: Breast cancer rates are increasing in Nigeria and across sub-Sahara Africa wit... more TPS622 Background: Breast cancer rates are increasing in Nigeria and across sub-Sahara Africa without the necessary infrastructure to manage the disease. Adequate clinical trial resources are needed to address the growing need for high quality, patient centered cancer care on the Continent. The ARETTA clinical trial was initiated by the Nigerian Breast Cancer Study Team in partnership with the University of Chicago Comprehensive Cancer Center. To build local capacity for biomarker informed clinical trials and translational research. Clinical investigators receive extensive training and local facilities at four University-based Cancer Centers in Southwest Nigeria were upgraded. The study is a pragmatic single-arm, phase II clinical trial to determine the safety and efficacy of neoadjuvant taxotere and trastuzumab in women with HER2-positive breast cancer. The study sought to 1) determine the pathological complete response (pCR) rate of patients with early stage breast cancer to neoad...
Precision Radiation Oncology
Nasopharyngeal carcinoma occurs worldwide. The incidence varies according to geographical region,... more Nasopharyngeal carcinoma occurs worldwide. The incidence varies according to geographical region, with the highest incidence recorded in Asian countries. In Nigeria, the incidence of nasopharyngeal carcinoma is increasing. Thus, current treatment outcomes must be evaluated to identify areas of possible improvement in the management of this disease. The present study aimed to evaluate the treatment outcome after 2 years in patients with nasopharyngeal carcinoma.
ecancermedicalscience, 2021
Background of the study Breast cancer is the most common cancer among women in both developed and... more Background of the study Breast cancer is the most common cancer among women in both developed and developing nations. The survival of breast cancer is increasing in developed countries with improved treatment modalities, while still very poor in developing countries. In Nigeria, few breast cancer survival data are available. Research design This is a retrospective cross-sectional study. Objectives To determine the survival of breast cancer patients and possible factors influencing it. Methodology Socio-demographic and clinical variables from treatment records and case notes of breast cancer patients treated from 1 January 2004 to 31 December 2008 at the Department of Radiation Oncology, University College Hospital, Ibadan. The status of patients was determined at 2 and 5 years after diagnosis. The survival of patients with breast cancer was compared using Log Rank test according to socio-demographic and clinical variables. The median survival times were obtained from the Kaplan–Meie...
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Papers by Ayorinde Folasire