Millions of people die each year from viral infections across the globe. There is an urgent need ... more Millions of people die each year from viral infections across the globe. There is an urgent need to overcome the existing gap and pitfalls of the current antiviral therapy which include increased dose and dosing frequency, bioavailability challenges, non-specificity, incidences of resistance and so on. These stumbling blocks could be effectively managed by the advent of nanomedicine. Current review emphasizes over an enhanced understanding of how different lipid, polymer and elemental based nanoformulations could be potentially and precisely used to bridle the said drawbacks in antiviral therapy. The dawn of nanotechnology meeting vaccine delivery, role of RNAi therapeutics in antiviral treatment regimen, various regulatory concerns towards clinical translation of nanomedicine along with current trends and implications including unexplored research avenues for advancing the current drug delivery have been discussed in detail.
The Amikacin loaded nanolipsomes were successfully formulated with characteristics similar to Ari... more The Amikacin loaded nanolipsomes were successfully formulated with characteristics similar to Arikayce ® with particle size range of less than 300nm. FUTURE WORK The future optimization of Ethanol injection method (formulation and process parameters), in vitro, and preclinical in vivo testing are needed to test the developed Amk-NLs.
World Journal of Pharmaceutical Research, Oct 1, 2017
Traditional medicines derived from medicinal plants are used by more than 60% of the world's popu... more Traditional medicines derived from medicinal plants are used by more than 60% of the world's population. Even though several differences exist between herbal and conventional pharmacological treatments, herbal medicines can be tested for efficacy using conventional trial of methodology. Shatavari churna is obtained from roots of Asparagus racemosus Will, family Liliaceae, is available in the market in various dosage forms like churna, kalpa, tablets, capsules and jams. Shatavari is consumed by pregnant and lactating women as it helps to maintain healthy levels of breast milk production, it is consumed by pediatrics as it helps boost immunity. [1] Microbial test is important aspect to maintain quality of herbal drugs. This includes analytical and microbiological testing as per pharmacopeia. To maintain potency of natural sources and excipients used in pharmaceutical preparation microbial limit test is performed. The microbial quality assessment of Shatavari churna is performed to check whether it's safety, efficacy and purity is maintained on long term storage. The present study focuses on microbiological evaluation of Shatavari churna.
Millions of people die each year from viral infections across the globe. There is an urgent need ... more Millions of people die each year from viral infections across the globe. There is an urgent need to overcome the existing gap and pitfalls of the current antiviral therapy which include increased dose and dosing frequency, bioavailability challenges, non-specificity, incidences of resistance and so on. These stumbling blocks could be effectively managed by the advent of nanomedicine. Current review emphasizes over an enhanced understanding of how different lipid, polymer and elemental based nanoformulations could be potentially and precisely used to bridle the said drawbacks in antiviral therapy. The dawn of nanotechnology meeting vaccine delivery, role of RNAi therapeutics in antiviral treatment regimen, various regulatory concerns towards clinical translation of nanomedicine along with current trends and implications including unexplored research avenues for advancing the current drug delivery have been discussed in detail.
The Amikacin loaded nanolipsomes were successfully formulated with characteristics similar to Ari... more The Amikacin loaded nanolipsomes were successfully formulated with characteristics similar to Arikayce ® with particle size range of less than 300nm. FUTURE WORK The future optimization of Ethanol injection method (formulation and process parameters), in vitro, and preclinical in vivo testing are needed to test the developed Amk-NLs.
World Journal of Pharmaceutical Research, Oct 1, 2017
Traditional medicines derived from medicinal plants are used by more than 60% of the world's popu... more Traditional medicines derived from medicinal plants are used by more than 60% of the world's population. Even though several differences exist between herbal and conventional pharmacological treatments, herbal medicines can be tested for efficacy using conventional trial of methodology. Shatavari churna is obtained from roots of Asparagus racemosus Will, family Liliaceae, is available in the market in various dosage forms like churna, kalpa, tablets, capsules and jams. Shatavari is consumed by pregnant and lactating women as it helps to maintain healthy levels of breast milk production, it is consumed by pediatrics as it helps boost immunity. [1] Microbial test is important aspect to maintain quality of herbal drugs. This includes analytical and microbiological testing as per pharmacopeia. To maintain potency of natural sources and excipients used in pharmaceutical preparation microbial limit test is performed. The microbial quality assessment of Shatavari churna is performed to check whether it's safety, efficacy and purity is maintained on long term storage. The present study focuses on microbiological evaluation of Shatavari churna.
Uploads
Papers by RAMA KASHIKAR