Cell therapy has attracted considerable interest as a promising therapeutic alternative for patie... more Cell therapy has attracted considerable interest as a promising therapeutic alternative for patients with Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural tissue can achieve considerable biochemical and clinical improvements in PD. However, the source of fetal tissue grafts is limited and ethically controversial. Human parthenogenetic stem cells offer a good alternative because they are derived from unfertilized oocytes without destroying potentially viable human embryos and can be used to generate an unlimited supply of neural cells for transplantation. We have previously reported that human parthenogenetic stem cellderived neural stem cells (hpNSCs) successfully engraft, survive long term, and increase brain dopamine (DA) levels in rodent and nonhuman primate models of PD. Here we report the results of a 12-month transplantation study of hpNSCs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned African green monkeys with moderate to ...
Regarding the diversified needs of the customers and various products of competitors, the importa... more Regarding the diversified needs of the customers and various products of competitors, the importance of agility in supply chain management becomes more significant. Suppliers should provide materials and essential resources of manufacturers without any lead time. In this research, we used a two-stage method for supplier selection. In the first stage, we used a new Data Envelopment Analysis (DEA) method based on network framework to determine the efficiency of the suppliers. This model considered 4 layers for supply chain of each supplier. At the end of this stage, the better suppliers have been selected for the second stage. In the second stage, after determining the efficient suppliers, we identified several criteria for agility in sanitation supply chain. Due to the uncertainty on the supplier's data, we used a fuzzy Delphi method and ideas of experts about those criteria have been finalized in 8 criteria. Next step was devoted to prioritization of 5 selected suppliers in sanitation industry based on the final criteria with fuzzy VIKOR.
Purpose: To characterize the nature and time course of optic nerve and retinal pathology followin... more Purpose: To characterize the nature and time course of optic nerve and retinal pathology following induction of non-arteritic anterior ischemic optic neuropathy (NAION) by focal photothrombotic insult to the optic nerve head (ONH) in African green monkeys, and to evaluate the effect of candidate neuroprotective agents in reducing the elicited pathology. Methods: Fifteen adult monkeys received unilateral ONH laser treatment (wavelength 532mm; power 100mW; spot size 500mm; duration 9 seconds x 4), immediately following intravenous administration of rose bengal (0.1 ml/kg of 25 mg/kg) to induce oxidative endothelial injury of ONH microvasculature. Eyes were evaluated by slit lamp exam, color fundus photography, fluorescence angiography, optical coherence tomography (OCT) and electroretinography (ERG) at baseline and days 1, 7, 14, 28, 56 and 84 post-laser. Apoptosis and necrosis inhibitors or vehicle were administered intravitreally immediately following laser treatment. Results: Photo...
Cell therapy has attracted considerable interest as a promising therapeutic alternative for patie... more Cell therapy has attracted considerable interest as a promising therapeutic alternative for patients with Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural tissue can achieve considerable biochemical and clinical improvements in PD. However, the source of fetal tissue grafts is limited and ethically controversial. Human parthenogenetic stem cells offer a good alternative because they are derived from unfertilized oocytes without destroying potentially viable human embryos and can be used to generate an unlimited supply of neural cells for transplantation. We have previously reported that human parthenogenetic stem cellderived neural stem cells (hpNSCs) successfully engraft, survive long term, and increase brain dopamine (DA) levels in rodent and nonhuman primate models of PD. Here we report the results of a 12-month transplantation study of hpNSCs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned African green monkeys with moderate to ...
Regarding the diversified needs of the customers and various products of competitors, the importa... more Regarding the diversified needs of the customers and various products of competitors, the importance of agility in supply chain management becomes more significant. Suppliers should provide materials and essential resources of manufacturers without any lead time. In this research, we used a two-stage method for supplier selection. In the first stage, we used a new Data Envelopment Analysis (DEA) method based on network framework to determine the efficiency of the suppliers. This model considered 4 layers for supply chain of each supplier. At the end of this stage, the better suppliers have been selected for the second stage. In the second stage, after determining the efficient suppliers, we identified several criteria for agility in sanitation supply chain. Due to the uncertainty on the supplier's data, we used a fuzzy Delphi method and ideas of experts about those criteria have been finalized in 8 criteria. Next step was devoted to prioritization of 5 selected suppliers in sanitation industry based on the final criteria with fuzzy VIKOR.
Purpose: To characterize the nature and time course of optic nerve and retinal pathology followin... more Purpose: To characterize the nature and time course of optic nerve and retinal pathology following induction of non-arteritic anterior ischemic optic neuropathy (NAION) by focal photothrombotic insult to the optic nerve head (ONH) in African green monkeys, and to evaluate the effect of candidate neuroprotective agents in reducing the elicited pathology. Methods: Fifteen adult monkeys received unilateral ONH laser treatment (wavelength 532mm; power 100mW; spot size 500mm; duration 9 seconds x 4), immediately following intravenous administration of rose bengal (0.1 ml/kg of 25 mg/kg) to induce oxidative endothelial injury of ONH microvasculature. Eyes were evaluated by slit lamp exam, color fundus photography, fluorescence angiography, optical coherence tomography (OCT) and electroretinography (ERG) at baseline and days 1, 7, 14, 28, 56 and 84 post-laser. Apoptosis and necrosis inhibitors or vehicle were administered intravitreally immediately following laser treatment. Results: Photo...
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Papers by Jordan Attwood