Vanadium, an essential micronutrient, has been implicated in controlling diabetes and carcinogene... more Vanadium, an essential micronutrient, has been implicated in controlling diabetes and carcinogenesis and in impeding reactive oxygen species (ROS) generation. γ-ray irradiation triggers DNA damage by inducing ROS production and causes diminution in radiosensitive immunocytes. In this study, we elucidate the immune activation capacities of Jeju water containing vanadium on immunosuppression caused by γ-ray irradiation, and identify its mechanism using various low doses of NaVO(3). We examined the intracellular ROS generation, DNA damage, cell proliferation, population of splenocytes, and cytokine/antibody profiles in irradiated mice drinking Jeju water for 180 days and in non-irradiated and in irradiated splenocytes both of which were treated with NaVO(3). Both Jeju water and 0.245 μM NaVO(3) attenuated the intracellular ROS generation and DNA damage in splenocytes against γ-ray irradiation. Splenocytes were significantly proliferated by the long-term intake of Jeju water and by 0.245 μM NaVO(3) treatment, and the expansion of B cells accounted for the increased number of splenocytes. Also, 0.245 μM NaVO(3) treatment showed the potency to amplify the production of IFN-γ and total IgG in irradiated splenocytes, which correlated with the expansion of B cells. Collectively, Jeju water containing vanadium possesses the immune activation property against damages caused by γ-irradiation.
Antioxidant property and hematopoietic repair capacity are important characteristics of radioprot... more Antioxidant property and hematopoietic repair capacity are important characteristics of radioprotective agents. Some studies have demonstrated that 1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose (PGG), a molecule isolated from the waterlily, has antioxidant, hematopoietic ...
Purpose: To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklon... more Purpose: To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklonia cava. Materials and methods: Mice were lethally irradiated, treated with dieckol and surveyed for survival and the mechanism of radioprotection. Results: Dieckol treatment lengthened the survival of irradiated mice and significantly accelerated the hemopoietic recovery of bone marrow cells and peripheral immune cells compared with irradiated, but untreated controls. Dieckol also enhanced the proliferation and differentiation of immune cells, which had been suppressed by ionising radiation. It turned out that the increased expression of oxygen radical-scavenging enzyme manganese superoxide dismutase (MnSOD) and subsequent reduction in DNA damage and lipid peroxidation was crucial for dieckol's radioprotective effect. In addition, the dieckolinduced modulation of protein 53 (p53)-dependent pathways further strengthened the radioresistance of immune cells. Conclusion: Dieckol can be a promising agent for reducing the time needed for reconstitution of hemopoietic cells after exposure to irradiation.
Vanadium, an essential micronutrient, has been implicated in controlling diabetes and carcinogene... more Vanadium, an essential micronutrient, has been implicated in controlling diabetes and carcinogenesis and in impeding reactive oxygen species (ROS) generation. γ-ray irradiation triggers DNA damage by inducing ROS production and causes diminution in radiosensitive immunocytes. In this study, we elucidate the immune activation capacities of Jeju water containing vanadium on immunosuppression caused by γ-ray irradiation, and identify its mechanism using various low doses of NaVO(3). We examined the intracellular ROS generation, DNA damage, cell proliferation, population of splenocytes, and cytokine/antibody profiles in irradiated mice drinking Jeju water for 180 days and in non-irradiated and in irradiated splenocytes both of which were treated with NaVO(3). Both Jeju water and 0.245 μM NaVO(3) attenuated the intracellular ROS generation and DNA damage in splenocytes against γ-ray irradiation. Splenocytes were significantly proliferated by the long-term intake of Jeju water and by 0.245 μM NaVO(3) treatment, and the expansion of B cells accounted for the increased number of splenocytes. Also, 0.245 μM NaVO(3) treatment showed the potency to amplify the production of IFN-γ and total IgG in irradiated splenocytes, which correlated with the expansion of B cells. Collectively, Jeju water containing vanadium possesses the immune activation property against damages caused by γ-irradiation.
Antioxidant property and hematopoietic repair capacity are important characteristics of radioprot... more Antioxidant property and hematopoietic repair capacity are important characteristics of radioprotective agents. Some studies have demonstrated that 1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose (PGG), a molecule isolated from the waterlily, has antioxidant, hematopoietic ...
Purpose: To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklon... more Purpose: To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklonia cava. Materials and methods: Mice were lethally irradiated, treated with dieckol and surveyed for survival and the mechanism of radioprotection. Results: Dieckol treatment lengthened the survival of irradiated mice and significantly accelerated the hemopoietic recovery of bone marrow cells and peripheral immune cells compared with irradiated, but untreated controls. Dieckol also enhanced the proliferation and differentiation of immune cells, which had been suppressed by ionising radiation. It turned out that the increased expression of oxygen radical-scavenging enzyme manganese superoxide dismutase (MnSOD) and subsequent reduction in DNA damage and lipid peroxidation was crucial for dieckol's radioprotective effect. In addition, the dieckolinduced modulation of protein 53 (p53)-dependent pathways further strengthened the radioresistance of immune cells. Conclusion: Dieckol can be a promising agent for reducing the time needed for reconstitution of hemopoietic cells after exposure to irradiation.
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Papers by So Jin Bing