Background: Gilles de la Tourette Syndrome (GTS) is a childhood-onset neuropsychiatric disorder c... more Background: Gilles de la Tourette Syndrome (GTS) is a childhood-onset neuropsychiatric disorder characterised by motor and vocal tics. While Comprehensive Behavioural Intervention for Tics (CBIT) is an effective, non-pharmacological treatment for patients with GTS, the underlying neurophysiological basis of this intervention has not been investigated. Methods: To investigate the clinical effectiveness of CBIT in reducing tic severity in young people with GTS and explore neurophysiological mechanisms associated with clinical change. Results: There was a significant overall improvement in tic severity of large effect size. The Cortical Silent Period (CSP) to motor evoked potential (MEP) ratio (CSP/MEP ratio) increased after the intervention with a small effect size. Other neurophysiological measures of inhibition were not significantly related to the change in tic severity. Conclusions: Alongside significant clinical improvements, these results suggest a role for motor cortical Gamma-aminobutyric acid (GABA)-ergic inhibitory circuitry in the neurophysiological changes underlying CBIT treatment. These findings need to be replicated in larger studies using control samples.
This project investigates whether word production is affected by semantic variables. Specifically... more This project investigates whether word production is affected by semantic variables. Specifically, we will simultaneously examine six feature-based semantic variables (number of near semantic neighbours, semantic similarity, number of semantic features, typicality, intercorrelational density, distinctiveness). This work will inform word production theory by (1) clarifying and dissociating effects of these semantic variables on word production; and (2) studying their temporal dynamics using EEG.
In cognitive neuroscience research, computational models of event-related potentials (ERP) can pr... more In cognitive neuroscience research, computational models of event-related potentials (ERP) can provide a means of developing explanatory hypotheses for the observed waveforms. However, researchers trained in cognitive neurosciences may face technical challenges in implementing these models. This paper provides a tutorial on developing recurrent neural network (RNN) models of ERP waveforms in order to facilitate broader use of computational models in ERP research. To exemplify the RNN model usage, the P3 component evoked by target and non-target visual events, measured at channel Pz, is examined. Input representations of experimental events and corresponding ERP labels are used to optimize the RNN in a supervised learning paradigm. Linking one input representation with multiple ERP waveform labels, then optimizing the RNN to minimize mean-squared-error loss, causes the RNN output to approximate the grand-average ERP waveform. Behavior of the RNN can then be evaluated as a model of th...
Oddballs, rare or novel stimuli, appear to last longer than non-oddballs. This illusion is often ... more Oddballs, rare or novel stimuli, appear to last longer than non-oddballs. This illusion is often attributed to the perceived time that an oddball occupies being longer than that of a non-oddball. However, it is also possible that oddball stimuli are perceived to onset earlier than non-oddballs; they are "gated" earlier in time and thus the perceived duration of those stimuli are longer. In the current article, we directly investigate this proposal by asking participants to react to, produce durations initiated with, and tap along to either oddball or standard stimuli. Tapping provided some support for earlier perceived onset of an oddball in the visual modality. However, both reaction time and duration production experiments provided evidence against an oddball being gated earlier than a standard stimulus. Contrarily, these experiments showed an oddball resulted in longer reaction times and productions, respectively. Taken together, these three experiments indicate it is unlikely that the expansion of time attributed to oddball presentation is purely due to the earlier gating of oddball stimuli. In fact, the first two experiments provide some evidence that the effect of an oddball must compensate for the later gating of these stimuli.
We examine participants' ability to accurately produce durations online, and their subjective rat... more We examine participants' ability to accurately produce durations online, and their subjective ratings of performance. Given the push tso move students online, it is necessary to transition to online experiments. However, this comes comes certain challenges. Therefore, we performed a duration production task in which participants produced, then rated the accuracy of these productions. Generally, results support the capacity for duration production to be moved online. Further, participants are at least partially aware of the accuracy of their productions, though their estimates varied. However, a caveat to this is that duration productions were slightly longer than the target duration.
Background Investigators have proposed that various physical head and neck characteristics, such ... more Background Investigators have proposed that various physical head and neck characteristics, such as neck strength and head and neck size, are associated with protection from mild traumatic brain injury (mTBI/concussion). Objectives To systematically review the literature and investigate potential relationships between physical head and neck characteristics and mTBI risk in athletic and military populations. Methods A comprehensive search of seven databases was conducted: MEDLINE, EMBASE, CINAHL, Scopus, SPORTDiscus, Cochrane Library, and Web of Science. Potential studies were systematically screened and reviewed. Studies on military and athletic cohorts were included if they assessed the relationship between physical head-neck characteristics and mTBI risk or proxy risk measures such as head impact kinematics. Results The systematic search yielded a total of 11,723 original records. From these, 22 studies met our inclusion criteria (10 longitudinal, 12 cross-sectional). Relevant to ...
Accurate diagnosis of sports related concussion ensures that athletes are removed from play if co... more Accurate diagnosis of sports related concussion ensures that athletes are removed from play if concussed and prevents incorrect removal when a concussion has not occurred. Although various screening tools are currently in use, there is no gold standard measure with which to diagnose sports related concussion. Objective: The current study aimed to investigate the diagnostic accuracy of the Abbreviated Westmead Post Traumatic Amnesia Scale (A-WPTAS) picture task, a neurocognitive measure used to assess mild traumatic brain injury. The incidence of false positive classifications and the potential confounding effect of exercise on scores on the A-WPTAS picture items were examined. Methods: The study included an athlete group comprising 33 players and a control group comprising 37 subjects. The A-WPTAS picture task was completed on three testing occasions, separated by three week intervals. Results: Results revealed that the A-WPTAS picture task was highly accurate (>95%) in correctly...
A neural biomarker that can be applied to studies of oral communication disorders would provide a... more A neural biomarker that can be applied to studies of oral communication disorders would provide a boon to researchers. While there has been much research conducted on manual response inhibition, very few studies have examined vocal response inhibition. To date, no study has examined the temporal aspects of vocal inhibition. Therefore, the present study attempted to identify the neural correlates of vocal response inhibition by recording electroencephalographic activity during a modified version of the stop signal task. We included an ignore signal condition matched for frequency and visual stimulation to the stop signal which importantly, was included in the same block of trials as the typical go and stop trials. Behavioural results showed that participants were able to inhibit a vocal response within approximately 324 ms. Statistical analysis of ERPs revealed that a positive component around 324 ms was significantly larger in amplitude during successfully stopped trials compared to...
The neural causes of stuttering remain unknown. One explanation comes from neuroimaging studies t... more The neural causes of stuttering remain unknown. One explanation comes from neuroimaging studies that have reported abnormal lateralization of activation in the brains of people who stutter. However, these findings are generally based on data from adults with a long history of stuttering, raising the possibility that the observed lateralization anomalies are compensatory rather than causal. The current study investigated lateralization of brain activity in language-related regions of interest in young children soon after the onset of stuttering. We tested 24 preschool-aged children, half of whom had a positive diagnosis of stuttering. All children participated in a picture-naming experiment whilst their brain activity was recorded by magnetoencephalography. Source analysis performed during an epoch prior to speech onset was used to assess lateralized activation in three regions of interest. Activation was significantly lateralized to the left hemisphere in both groups and not different between groups.This study shows for the first time that significant speech preparatory brain activation can be identified in young children during picture-naming and supports the contention that, in stutterers, aberrant lateralization of brain function may be the result of neuroplastic adaptation that occurs as the condition becomes chronic.
During bimanual load lifting, the brain must anticipate the effects of unloading upon the load-be... more During bimanual load lifting, the brain must anticipate the effects of unloading upon the load-bearing arm. Little is currently known about the neural networks that coordinate these anticipatory postural adjustments. We measured neuromagnetic brain activity with whole-head magnetoencephalography while participants performed a bimanual load-lifting task. Anticipatory adjustments were associated with reduction in biceps brachii muscle activity of the loadbearing arm and pre-movement desynchronization of the cortical beta rhythm. Beamforming analyses localized anticipatory brain activity to the precentral gyrus, basal ganglia, supplementary motor area, and thalamus, contralateral to the load-bearing arm. To our knowledge this is the first human neuroimaging study to directly investigate anticipatory postural adjustments and to explicitly partition the anticipatory and volitional aspects of brain activity in bimanual load lifting. These data contribute to our understanding of the neural systems supporting anticipatory postural adjustments in healthy adults.
While stuttering is known to be characterized by anomalous brain activations during speech, very ... more While stuttering is known to be characterized by anomalous brain activations during speech, very little data is available describing brain activations during stuttering. To our knowledge there are no reports describing brain activations that precede blocking. In this case report we present magnetoencephalographic data from a person who stutters who had significant instances of blocking whilst performing a vowel production task. This unique data set has allowed us to compare the brain activations leading up to a block with those leading up to successful production. Surprisingly, the results are very consistent with data comparing fluent production in stutterers to controls. We show here that preceding a block there is significantly less activation of the left orbitofrontal and inferiorfrontal cortices. Furthermore, there is significant extra activation in the right orbitofrontal and inferiorfrontal cortices, and the sensorimotor and auditory areas bilaterally. This data adds weight to the argument forwarded by Kell et al. (2009) that the best functional sign of optimal repair in stutterering is activation of the left BA 47/12 in the orbitofrontal cortex. At the end of this activity the reader will be able to (a) identify brain regions associated with blocked vocalization, (b) discuss the functions of the orbitofrontal and inferior frontal cortices in regard to speech production and (c) describe the usefulness and limitations of magnetoencephalography (MEG) in stuttering research.
Description Overactivation of the right inferior frontal gyrus, an area of the brain that underpi... more Description Overactivation of the right inferior frontal gyrus, an area of the brain that underpins voluntary arrest of action, has been associated with stuttering. While there has been much research conducted on manual response inhibition, very few studies have examined vocal response inhibition and to date, no study has examined the temporal neurodynamics of vocal inhibition. Therefore, the first part of the present study identified, in a group of control participants, the temporal neural correlates of vocal response inhibition by ...
The fluent production of speech requires accurately timed movements. In this article, we propose ... more The fluent production of speech requires accurately timed movements. In this article, we propose that a deficit in brain timing networks is one of the core neurophysiological deficits in stuttering. We first discuss the experimental evidence supporting the involvement of the basal ganglia and supplementary motor area (SMA) in stuttering and the involvement of the cerebellum as a possible mechanism for compensating for the neural deficits that underlie stuttering. Next, we outline the involvement of the right inferior frontal gyrus (IFG) as another putative compensatory locus in stuttering and suggest a role for this structure in an expanded core timing-network. Subsequently, we review behavioral studies of timing in people who stutter and examine their behavioral performance as compared to people who do not stutter. Finally, we highlight challenges to existing research and provide avenues for future research with specific hypotheses.
Background: Gilles de la Tourette Syndrome (GTS) is a childhood-onset neuropsychiatric disorder c... more Background: Gilles de la Tourette Syndrome (GTS) is a childhood-onset neuropsychiatric disorder characterised by motor and vocal tics. While Comprehensive Behavioural Intervention for Tics (CBIT) is an effective, non-pharmacological treatment for patients with GTS, the underlying neurophysiological basis of this intervention has not been investigated. Methods: To investigate the clinical effectiveness of CBIT in reducing tic severity in young people with GTS and explore neurophysiological mechanisms associated with clinical change. Results: There was a significant overall improvement in tic severity of large effect size. The Cortical Silent Period (CSP) to motor evoked potential (MEP) ratio (CSP/MEP ratio) increased after the intervention with a small effect size. Other neurophysiological measures of inhibition were not significantly related to the change in tic severity. Conclusions: Alongside significant clinical improvements, these results suggest a role for motor cortical Gamma-aminobutyric acid (GABA)-ergic inhibitory circuitry in the neurophysiological changes underlying CBIT treatment. These findings need to be replicated in larger studies using control samples.
This project investigates whether word production is affected by semantic variables. Specifically... more This project investigates whether word production is affected by semantic variables. Specifically, we will simultaneously examine six feature-based semantic variables (number of near semantic neighbours, semantic similarity, number of semantic features, typicality, intercorrelational density, distinctiveness). This work will inform word production theory by (1) clarifying and dissociating effects of these semantic variables on word production; and (2) studying their temporal dynamics using EEG.
In cognitive neuroscience research, computational models of event-related potentials (ERP) can pr... more In cognitive neuroscience research, computational models of event-related potentials (ERP) can provide a means of developing explanatory hypotheses for the observed waveforms. However, researchers trained in cognitive neurosciences may face technical challenges in implementing these models. This paper provides a tutorial on developing recurrent neural network (RNN) models of ERP waveforms in order to facilitate broader use of computational models in ERP research. To exemplify the RNN model usage, the P3 component evoked by target and non-target visual events, measured at channel Pz, is examined. Input representations of experimental events and corresponding ERP labels are used to optimize the RNN in a supervised learning paradigm. Linking one input representation with multiple ERP waveform labels, then optimizing the RNN to minimize mean-squared-error loss, causes the RNN output to approximate the grand-average ERP waveform. Behavior of the RNN can then be evaluated as a model of th...
Oddballs, rare or novel stimuli, appear to last longer than non-oddballs. This illusion is often ... more Oddballs, rare or novel stimuli, appear to last longer than non-oddballs. This illusion is often attributed to the perceived time that an oddball occupies being longer than that of a non-oddball. However, it is also possible that oddball stimuli are perceived to onset earlier than non-oddballs; they are "gated" earlier in time and thus the perceived duration of those stimuli are longer. In the current article, we directly investigate this proposal by asking participants to react to, produce durations initiated with, and tap along to either oddball or standard stimuli. Tapping provided some support for earlier perceived onset of an oddball in the visual modality. However, both reaction time and duration production experiments provided evidence against an oddball being gated earlier than a standard stimulus. Contrarily, these experiments showed an oddball resulted in longer reaction times and productions, respectively. Taken together, these three experiments indicate it is unlikely that the expansion of time attributed to oddball presentation is purely due to the earlier gating of oddball stimuli. In fact, the first two experiments provide some evidence that the effect of an oddball must compensate for the later gating of these stimuli.
We examine participants' ability to accurately produce durations online, and their subjective rat... more We examine participants' ability to accurately produce durations online, and their subjective ratings of performance. Given the push tso move students online, it is necessary to transition to online experiments. However, this comes comes certain challenges. Therefore, we performed a duration production task in which participants produced, then rated the accuracy of these productions. Generally, results support the capacity for duration production to be moved online. Further, participants are at least partially aware of the accuracy of their productions, though their estimates varied. However, a caveat to this is that duration productions were slightly longer than the target duration.
Background Investigators have proposed that various physical head and neck characteristics, such ... more Background Investigators have proposed that various physical head and neck characteristics, such as neck strength and head and neck size, are associated with protection from mild traumatic brain injury (mTBI/concussion). Objectives To systematically review the literature and investigate potential relationships between physical head and neck characteristics and mTBI risk in athletic and military populations. Methods A comprehensive search of seven databases was conducted: MEDLINE, EMBASE, CINAHL, Scopus, SPORTDiscus, Cochrane Library, and Web of Science. Potential studies were systematically screened and reviewed. Studies on military and athletic cohorts were included if they assessed the relationship between physical head-neck characteristics and mTBI risk or proxy risk measures such as head impact kinematics. Results The systematic search yielded a total of 11,723 original records. From these, 22 studies met our inclusion criteria (10 longitudinal, 12 cross-sectional). Relevant to ...
Accurate diagnosis of sports related concussion ensures that athletes are removed from play if co... more Accurate diagnosis of sports related concussion ensures that athletes are removed from play if concussed and prevents incorrect removal when a concussion has not occurred. Although various screening tools are currently in use, there is no gold standard measure with which to diagnose sports related concussion. Objective: The current study aimed to investigate the diagnostic accuracy of the Abbreviated Westmead Post Traumatic Amnesia Scale (A-WPTAS) picture task, a neurocognitive measure used to assess mild traumatic brain injury. The incidence of false positive classifications and the potential confounding effect of exercise on scores on the A-WPTAS picture items were examined. Methods: The study included an athlete group comprising 33 players and a control group comprising 37 subjects. The A-WPTAS picture task was completed on three testing occasions, separated by three week intervals. Results: Results revealed that the A-WPTAS picture task was highly accurate (>95%) in correctly...
A neural biomarker that can be applied to studies of oral communication disorders would provide a... more A neural biomarker that can be applied to studies of oral communication disorders would provide a boon to researchers. While there has been much research conducted on manual response inhibition, very few studies have examined vocal response inhibition. To date, no study has examined the temporal aspects of vocal inhibition. Therefore, the present study attempted to identify the neural correlates of vocal response inhibition by recording electroencephalographic activity during a modified version of the stop signal task. We included an ignore signal condition matched for frequency and visual stimulation to the stop signal which importantly, was included in the same block of trials as the typical go and stop trials. Behavioural results showed that participants were able to inhibit a vocal response within approximately 324 ms. Statistical analysis of ERPs revealed that a positive component around 324 ms was significantly larger in amplitude during successfully stopped trials compared to...
The neural causes of stuttering remain unknown. One explanation comes from neuroimaging studies t... more The neural causes of stuttering remain unknown. One explanation comes from neuroimaging studies that have reported abnormal lateralization of activation in the brains of people who stutter. However, these findings are generally based on data from adults with a long history of stuttering, raising the possibility that the observed lateralization anomalies are compensatory rather than causal. The current study investigated lateralization of brain activity in language-related regions of interest in young children soon after the onset of stuttering. We tested 24 preschool-aged children, half of whom had a positive diagnosis of stuttering. All children participated in a picture-naming experiment whilst their brain activity was recorded by magnetoencephalography. Source analysis performed during an epoch prior to speech onset was used to assess lateralized activation in three regions of interest. Activation was significantly lateralized to the left hemisphere in both groups and not different between groups.This study shows for the first time that significant speech preparatory brain activation can be identified in young children during picture-naming and supports the contention that, in stutterers, aberrant lateralization of brain function may be the result of neuroplastic adaptation that occurs as the condition becomes chronic.
During bimanual load lifting, the brain must anticipate the effects of unloading upon the load-be... more During bimanual load lifting, the brain must anticipate the effects of unloading upon the load-bearing arm. Little is currently known about the neural networks that coordinate these anticipatory postural adjustments. We measured neuromagnetic brain activity with whole-head magnetoencephalography while participants performed a bimanual load-lifting task. Anticipatory adjustments were associated with reduction in biceps brachii muscle activity of the loadbearing arm and pre-movement desynchronization of the cortical beta rhythm. Beamforming analyses localized anticipatory brain activity to the precentral gyrus, basal ganglia, supplementary motor area, and thalamus, contralateral to the load-bearing arm. To our knowledge this is the first human neuroimaging study to directly investigate anticipatory postural adjustments and to explicitly partition the anticipatory and volitional aspects of brain activity in bimanual load lifting. These data contribute to our understanding of the neural systems supporting anticipatory postural adjustments in healthy adults.
While stuttering is known to be characterized by anomalous brain activations during speech, very ... more While stuttering is known to be characterized by anomalous brain activations during speech, very little data is available describing brain activations during stuttering. To our knowledge there are no reports describing brain activations that precede blocking. In this case report we present magnetoencephalographic data from a person who stutters who had significant instances of blocking whilst performing a vowel production task. This unique data set has allowed us to compare the brain activations leading up to a block with those leading up to successful production. Surprisingly, the results are very consistent with data comparing fluent production in stutterers to controls. We show here that preceding a block there is significantly less activation of the left orbitofrontal and inferiorfrontal cortices. Furthermore, there is significant extra activation in the right orbitofrontal and inferiorfrontal cortices, and the sensorimotor and auditory areas bilaterally. This data adds weight to the argument forwarded by Kell et al. (2009) that the best functional sign of optimal repair in stutterering is activation of the left BA 47/12 in the orbitofrontal cortex. At the end of this activity the reader will be able to (a) identify brain regions associated with blocked vocalization, (b) discuss the functions of the orbitofrontal and inferior frontal cortices in regard to speech production and (c) describe the usefulness and limitations of magnetoencephalography (MEG) in stuttering research.
Description Overactivation of the right inferior frontal gyrus, an area of the brain that underpi... more Description Overactivation of the right inferior frontal gyrus, an area of the brain that underpins voluntary arrest of action, has been associated with stuttering. While there has been much research conducted on manual response inhibition, very few studies have examined vocal response inhibition and to date, no study has examined the temporal neurodynamics of vocal inhibition. Therefore, the first part of the present study identified, in a group of control participants, the temporal neural correlates of vocal response inhibition by ...
The fluent production of speech requires accurately timed movements. In this article, we propose ... more The fluent production of speech requires accurately timed movements. In this article, we propose that a deficit in brain timing networks is one of the core neurophysiological deficits in stuttering. We first discuss the experimental evidence supporting the involvement of the basal ganglia and supplementary motor area (SMA) in stuttering and the involvement of the cerebellum as a possible mechanism for compensating for the neural deficits that underlie stuttering. Next, we outline the involvement of the right inferior frontal gyrus (IFG) as another putative compensatory locus in stuttering and suggest a role for this structure in an expanded core timing-network. Subsequently, we review behavioral studies of timing in people who stutter and examine their behavioral performance as compared to people who do not stutter. Finally, we highlight challenges to existing research and provide avenues for future research with specific hypotheses.
Uploads
Papers by Paul Sowman