Papers by Tomer Noyhouzer
Environmental science, 2021
Schematic representation of a carbon-based portable electrochemical filtration device designed to... more Schematic representation of a carbon-based portable electrochemical filtration device designed to remove toxic amounts of lead and arsenic found in drinking water.
Meeting abstracts, 2015
Drug delivery systems are one of the biggest challenges and emerging fields in the world nowadays... more Drug delivery systems are one of the biggest challenges and emerging fields in the world nowadays. There is a wide interest in developing an efficient method that will be able to transport a biologically active material to a desired location, and then releasing it using a simple process. From the different approaches that tried to overcome the different developing challenges only four nanoparticle-based drug delivery platforms were approved by the Food and Drug Administration (FDA). We present here a novel design of a smart drug delivery liposomes based on the use of redox active phospholipids. The redox triggering is very sensitive to small and local changes; therefore it can be applied without affecting other species in the environment as opposed to pH, temperature, ultrasound and photochemistry changes. The system was characterized using advanced methods such as SECM, TEM, DLS and immunoarray fluorescent imaging. Furthermore, when loading the vesicles with anti-cancer medicine and exposing them to live cell we show that the redox induced payload mechanism is fully functional making it a promising candidate for a fully functional drug delivery system Figure 1
Analytical Chemistry, Aug 15, 2013
Journal of The Electrochemical Society, 2018
Langmuir, Apr 21, 2016
Controlled payload release is one of the key elements in the creation of a reliable drug delivery... more Controlled payload release is one of the key elements in the creation of a reliable drug delivery system. We report the discovery of a drug delivery vessel able to transport chemotherapeutic agents to target cancer cells and selectively trigger their release using the electrochemical activity of a ferrocene-modified phospholipid. Supported by in vitro assays, the competitive advantages of this discovery are (i) the simple one step scalability of the synthetic process, (ii) the stable encapsulation of toxic drugs (doxorubicin) during transport, and (iii) the selective redox triggering of the liposomes to harness their cytotoxic payload at the cancer site. Specifically, the redox-modified giant unilamellar vesicle and liposomes were characterized using advanced methods such as scanning electrochemical microscopy (SECM), transmission electron microscopy (TEM), dynamic light scattering (DLS), and fluorescent imaging.
Electrocatalysis, Feb 26, 2018
The relationship between the potential of the cell reaction (E cell), the entropy change (ΔS), an... more The relationship between the potential of the cell reaction (E cell), the entropy change (ΔS), and the enthalpy change (ΔH) is well established. Yet, there is surprisingly a very narrow range of experimental aqueous galvanic cells that follow thermodynamic predictions. The redox and equilibrium reactions used within Pourbaix diagrams are presented a priori to establish the limitations and application range of thermodynamic relationships within complex electrochemical systems, the Zn-Cu (Daniell cell) and Pb-Cu cells. These are then tested to validate the theoretical discussion. Specifically, the electromotive force of both cells is measured as a function of the temperature in order to calculate the thermodynamic properties of the reaction: concomitantly to the voltage measurements, the temperature, the pH, and the surface state of the electrodes.
Electroanalysis, Oct 16, 2012
Remote sensing is a fast developing field. The ability to detect various elements in secluded or ... more Remote sensing is a fast developing field. The ability to detect various elements in secluded or inaccessible areas holds great opportunities. Here we present a new electrochemical flow cell which was developed as part of an autonomous flow system for measuring heavy metals in aquatic environments. The system was designed for remote sensing. Our system can utilize different commercially available electrodes and apply a range of electrochemical methods. The system was studied through both electrochemical experiments and simulation. The potential of the platform was demonstrated by analyzing seawater spiked with cadmium. Good agreement was found between our results and those obtained by ICP-MS analysis.
Analytica Chimica Acta, 2011
The electrochemical determination of low levels of Cd using a self-assembled monolayer (SAM) modi... more The electrochemical determination of low levels of Cd using a self-assembled monolayer (SAM) modified Au electrode is reported. Determination was based on the stripping of Cd, which was deposited by under potential deposition (UPD). A series of short alkanethiol SAMs bearing different end groups, i.e., sulfonate, carboxylate and ammonium, were examined. Lowest level of detection (ca. 50 ng L −1) was achieved with a 3-mercaptopropionic acid (MPA) monolayer using subtractive anodic square wave voltammetry (SASV). Additional surface methods, namely, reductive desorption and X-ray photoelectron spectroscopy, were applied to determine the interfacial structure of the electrodeposited Cd on the modified electrodes. We conclude that the deposited Cd forms a monoatomic layer, which bridges between the gold surface and the alkanethiol monolayer associating with both the gold and the sulfur atoms.
Analytical Methods, 2009
ABSTRACT Milk is one of the most fundamental ingredients in our diet. It is a complex biological ... more ABSTRACT Milk is one of the most fundamental ingredients in our diet. It is a complex biological fluid, which contains numerous substances, ranging from metal ions to enzymes. There is a constant search for an improved way of monitoring its quality and freshness. These are highly affected by the redox state of milk, which is governed by different species. In this study, we investigated the redox state and capacity of milk. Specifically, milk was potentiometrically titrated using different redox mediators, which enabled facilitation of electron transfer between different oxidizable species and the electrode. We found that the iodine/iodideredox couple was superior for measuring the redox capacity of milk. These measurements revealed that milk is not a well-poised system due to the presence of at least two different oxidizable species, one of which is hydrophobic while the other is hydrophilic and therefore could be separated by phase separation of milk.
Nanostructure science and technology, 2014
Analytical Chemistry, 2013
Analytical Chemistry, Apr 28, 2017
Nanostructure Science and Technology, 2014
Voltammetry involves the application of a potential that varies with time and the measurement of ... more Voltammetry involves the application of a potential that varies with time and the measurement of a current that flows between a working and a reference electrode. Voltammetry can therefore be defined as the exploration of the three-dimensional space that relates to potential, current, and time.1 However, under suitable circumstances, simplified conditions can lead to a unique relation, not involving time, between current and potential; such situation provides the so-called steady-state voltammetry.2
Analytical chemistry, Jan 16, 2017
A new type of flow platform for electrochemical and spectroelectrochemical measurements is presen... more A new type of flow platform for electrochemical and spectroelectrochemical measurements is presented. Finite element method simulations confirm that the hydrodynamic profile within the device is not turbulent and provides an analytical platform for the investigation of homogeneous kinetics, radical lifetimes, and reaction mechanisms. The modular "plug and play" configuration of the platform allows one to carry out electrochemistry and spectroscopy individually or simultaneously. Specific demonstrations of electroanalytical measurements using the flow system platform includes voltammetric analysis of organometallic compounds and quantitative analysis of ascorbic acid in commercial orange juice samples. Combined spectroelectrochemical demonstrations include electrochemical luminescence of ruthenium compounds and ligand exchange reactions of iron complexes using UV-vis spectroscopy.
Analytical Chemistry, 2013
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Papers by Tomer Noyhouzer