Wikidata:Property proposal/phase

clinical trial phase

Originally proposed at Wikidata:Property proposal/Natural science

Done: clinical trial phase (P6099) (Talk and documentation)

Description	phase designation for a clinical trial
Represents	phase of clinical research (Q7180990)
Data type	Item
Template parameter	none
Domain	instance of or subclass of clinical trial (Q30612)
Allowed values	item
Allowed units	none
Example 1	PARAMOUNT trial (Q17148583) → phase III clinical trial (Q42824827)
Example 2	RV 144 (Q7278028) → phase III clinical trial (Q42824827)
Example 3	When to Start Anti-HIV Drugs in Patients With Opportunistic Infections (Q47681748) → phase IV clinical trial (Q42825046)
Example 4	Evaluation of the Single-Use Pre-Filled Autoinjector (Q57949859) → phase I clinical trial (Q42824069)
Planned use	import clinical trial (Q30612) datasets from ClinicalTrials.gov (Q5133746)
Expected completeness	always incomplete (Q21873886)

Motivation

With some collaborators I am seeking to import clinical trial records from the database ClinicalTrials.gov (Q5133746).

ClinicalTrials.gov uses "phase" as a defining property of "clinical trials", which is human subject medical research. Anyone considering a trial would want to know the phase. We should establish a property for phase because everyone in the field knows this term, and because I find no equivalent existing property in Wikidata, and because ClinicalTrials.gov is representative of how all clinical trials databases have data for indicating the phase.

The "phase" is a declared scope for the research. Phase 1 examines a light dose or treatment on a few people, phase 2 examines a higher dose on more, 3 is a therapeutic dose on a few test subjects, and phase 4 is examining as much data as possible on anyone using it. There are some other phases but they all get precise definitions.

Background on clinical trials

The ClinicalTrials.gov (Q5133746) database from the US Federal Government presents about 300,000 trials in 200 countries. The data of these trials interconnect with drug names; researchers, universities, hospitals, and research institutes; papers in WikiCite; and grants. Eventually Wikidata will have linked items among the clinical trials, papers from those trials, the people who conducted them, the sponsors, the organizations which took funding for research, and the locations where the research happened. Medicine is about 10% of global GDP and the infrastructure of clinical trials employs the majority of the world's professional scientists, so I expect others to look in on this.

Reusing this property

Besides medicine there are other fields which use the designation "phase". I am not sure which of them might match the sense of this use, but if other classes of items have "phases" then this property could work for those items. It seems that archaeology routinely names each archaeological excavation (Q959782) with an Archaeological phase (Q4785465) but in the 26 excavations in Wikidata I see no modeling of phase.

Update This property is only for clinical trials. In clinical trials "phase" is a technical term with a certain meaning which does not easily translate to other uses. Also, some we do not have examples or modeling or any good proposal of how to use this concept in any other way. I revise the proposal for potential other use to narrow this only to phase of a clinical trial. Blue Rasberry (talk) 19:42, 7 November 2018 (UTC)[reply]

Blue Rasberry (talk) 15:18, 29 October 2018 (UTC)[reply]

Discussion

Support David (talk) 07:06, 30 October 2018 (UTC)[reply]
Support--Ozzie10aaaa (talk) 15:33, 30 October 2018 (UTC)[reply]
Support Andrew Su (talk) 19:06, 30 October 2018 (UTC)[reply]
Support. Csisc (talk) 19:43, 30 October 2018 (UTC)[reply]
Wait While I think it would be good to have a property for this, I'm not happy with the current description and label. Either we have a more specialized name like "clinical trial phase" and a corresponding description or we have a more general name like "phase" and a more general description. A mix is bad. ChristianKl ❪✉❫ 10:43, 4 November 2018 (UTC)[reply]

@ChristianKl: How is this for a compromise - I imagined that there were other senses beyond clinical trials for which "phase" would apply. I have looked around and asked around and I have not found a close match. If anyone has ideas, then at this proposal phase, I would work to incorporate other senses. If by the end of the proposal no one has other ideas, then we go with "clinical trial phase" and narrow this property to mean only that.

I imagined that there might be some formal system in some other field for designating research or projects to go in phases, but I might be mistaken. Perhaps this concept of "phase" is only so formal and only so defined in clinical research, and not anywhere else. Blue Rasberry (talk) 18:59, 6 November 2018 (UTC)[reply]

@Bluerasberry: I agree that it should be specific to clinical trials. Can you narrow the domain a bit? Would it only be applicable to instances of (subclasses of) clinical trial (Q30612) or would this property also be applicable to scientific papers based on those trials, or other related items? ArthurPSmith (talk) 19:39, 7 November 2018 (UTC)[reply]

@ArthurPSmith: I made changes as you and Christian suggested to apply this property only to clinical trials. I narrowed the domain to expect this to be on items which are clinical trials, and I also provided an explanation that this property is specific to clinical trials and not to be applied to other senses of the term "phase".

One of the goals of this property is to make items for clinical trials and match those trials to research papers describing the outcomes. I do not think it appropriate to apply the concept of phase to a paper. I do not think it will even be useful to note the phase of the research in the paper. When papers and trials are linked, it should be possible to query, for example, "show me instances of scholarly article (Q13442814) which have as their main subject an item which is an instance of a clinical trial (Q30612) where research intervention (P4844) = pemetrexed (Q415220) and phase = phase III clinical trial (Q42824827)". In that kind of scheme the phase stays on the trial. Papers frequently mention studies of various phases - the concept does not apply to papers. Blue Rasberry (talk) 19:55, 7 November 2018 (UTC)[reply]

Thanks, it all makes sense, I marked as ready to create. ArthurPSmith (talk) 19:58, 7 November 2018 (UTC)[reply]

@Bluerasberry, ديفيد عادل وهبة خليل 2, ChristianKl, ArthurPSmith, Andrew Su, Csisc: @Ozzie10aaaa: Done: clinical trial phase (P6099). − Pintoch (talk) 23:14, 7 November 2018 (UTC)[reply]