(Q91604246)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

title

Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

author name string

Syed Moiz Ahmed

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

publication date

31 August 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

page(s)

2062-2078

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

23 April 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6763970/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells

23 February 2021

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Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

23 February 2021

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Pharmacoinformatics analysis of merbarone binding site in human topoisomerase IIα

23 February 2021

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23 February 2021

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A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication

23 February 2021

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High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia

23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia

23 February 2021

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Oncofetal HMGA2 effectively curbs unconstrained (+) and (-) DNA supercoiling

23 February 2021

1 reference

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HMGA2 regulates lung cancer proliferation and metastasis

23 February 2021

1 reference

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Looping-out mechanism for resolution of replicative stress at telomeres

23 February 2021

1 reference

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Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci

23 February 2021

1 reference

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The Causes and Consequences of Topological Stress during DNA Replication

23 February 2021

1 reference

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Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?

23 February 2021

1 reference

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Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

23 February 2021

1 reference

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Cell-based high-throughput compound screening reveals functional interaction between oncofetal HMGA2 and topoisomerase I.

23 February 2021

1 reference

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The hematopoietic stem-cell niche in health and leukemia

23 February 2021

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Collision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' Adducts

23 February 2021

1 reference

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Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer.

23 February 2021

1 reference

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Increasing role of the cancer chemotherapeutic doxorubicin in cellular metabolism

23 February 2021

1 reference

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Replicating through telomeres: a means to an end.

23 February 2021

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High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX.

23 February 2021

1 reference

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Replication stress and cancer

23 February 2021

1 reference

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High mobility group a proteins as tumor markers

23 February 2021

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Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction

23 February 2021

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DNA break mapping reveals topoisomerase II activity genome-wide

23 February 2021

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TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres

23 February 2021

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Chaperoning HMGA2 protein protects stalled replication forks in stem and cancer cells.

23 February 2021

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Replication-dependent and transcription-dependent mechanisms of DNA double-strand break induction by the topoisomerase 2-targeting drug etoposide

23 February 2021

1 reference

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Mechanisms regulating resistance to inhibitors of topoisomerase II.

23 February 2021

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The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells

23 February 2021

1 reference

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HMGA2 is a driver of tumor metastasis.

23 February 2021

1 reference

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HMGA2 and high-grade serous ovarian carcinoma

23 February 2021

1 reference

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Anthracyclines as effective anticancer drugs

23 February 2021

1 reference

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HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells

23 February 2021

1 reference

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Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems.

23 February 2021

1 reference

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Drugging topoisomerases: lessons and challenges

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Concise review: bone marrow mononuclear cells for the treatment of ischemic syndromes: medicinal product or cell transplantation?

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

The DNA topoisomerase II catalytic inhibitor merbarone is genotoxic and induces endoreduplication

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Etoposide-mediated glioblastoma cell death: dependent or independent on the expression of its target, topoisomerase II alpha?

23 February 2021

1 reference

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HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers.

23 February 2021

1 reference

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Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases

23 February 2021

1 reference

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DNA topoisomerase II enzymes as molecular targets for cancer chemotherapy

23 February 2021

1 reference

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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

23 February 2021

1 reference

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Nuclear functions of the HMG proteins

23 February 2021

1 reference

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Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

23 February 2021

1 reference

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The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells?

23 February 2021

1 reference

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HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Targeting DNA topoisomerase II in cancer chemotherapy

23 February 2021

1 reference

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HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Topoisomerase levels determine chemotherapy responsein vitroandin vivo

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Do cells let-7 determine stemness?

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Roles of HMGA proteins in cancer

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

DNA topoisomerase II, genotoxicity, and cancer

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

HMGB1 interacts with human topoisomerase IIalpha and stimulates its catalytic activity.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Oncogenic HMGA2: short or small?

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Differential cell cycle-specificity for chromosomal damage induced by merbarone and etoposide in V79 cells

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Topoisomerase II and the etiology of chromosomal translocations

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Increased expression of high mobility group A proteins in lung cancer.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

DNA topoisomerase IIalpha expression and the response toprimary chemotherapy in breast cancer

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Catalytic topoisomerase II inhibitors in cancer therapy.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Catalytic inhibitors of topoisomerase II are DNA-damaging agents: induction of chromosomal damage by merbarone and ICRF-187.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Cellular roles of dna topoisomerases: a molecular perspective

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Human ARF protein interacts with topoisomerase I and stimulates its activity

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase IIalpha by enhancing the rate of ATP hydrolysis

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Etoposide: four decades of development of a topoisomerase II inhibitor

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Clinical applications of anticancer drugs targeted to topoisomerase II

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Intranuclear distribution of HMGI/Y proteins. An immunocytochemical study

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

DNA topoisomerase II mutations and resistance to anti-tumor drugs

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Modulation of DNA Topoisomerase I Activity byp53

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Protein tracking-induced supercoiling of DNA: a tool to regulate DNA transactions in vivo?

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Metaphase chromosome structure: bands arise from a differential folding path of the highly AT-rich scaffold

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Merbarone: an antitumor agent entering clinical trials

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Topoisomerase II: A specific marker for cell proliferation

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6763970

23 February 2021

Identifiers

DOI

10.1002/1878-0261.12541

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31271486%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

PubMed publication ID

31271486

1 reference