(Q79987571)

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The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro

scientific article published on 19 March 2007

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17372590%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro (English)

1 reference

Europe PubMed Central

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27 December 2019

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Yajun Zhou

1

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27 December 2019

Shizhong Zheng

2

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27 December 2019

Jianguo Lin

3

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27 December 2019

Qian-Jin Zhang

4

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27 December 2019

Anping Chen

5

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27 December 2019

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19 March 2007

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27 December 2019

Laboratory Investigation

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27 December 2019

87

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27 December 2019

5

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27 December 2019

488-498

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27 December 2019

Hepatic stellate cells and the reversal of fibrosis

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Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation

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Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth

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Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro

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