(Q64926815)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31216345%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

title

Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms (English)

1 reference

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2 May 2020

1

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2 May 2020

author name string

Lene Wierød

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31216345%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Soheil Naderi

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31216345%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

publication date

19 June 2019

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2 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31216345%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31216345%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

issue

6

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2 May 2020

page(s)

e0218537

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Creative Commons Attribution 4.0 International

2 May 2020

copyright license

start time

19 June 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element

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12 December 2020

Activation of LDL receptor gene expression in HepG2 cells by hepatocyte growth factor.

1 reference

12 December 2020

Stabilization and cytoskeletal-association of LDL receptor mRNA are mediated by distinct domains in its 3' untranslated region.

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12 December 2020

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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12 December 2020

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

12 December 2020

Specificity of short interfering RNA determined through gene expression signatures

1 reference

12 December 2020

A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities

1 reference

12 December 2020

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

1 reference

12 December 2020

Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1

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12 December 2020

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

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12 December 2020

Inhibition of low density lipoprotein receptor expression by long-term exposure to phorbol ester via p38 mitogen-activated protein kinase pathway

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12 December 2020

Protein sensors for membrane sterols

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12 December 2020

Opposing Roles for Akt1 and Akt2 in Rac/Pak Signaling and Cell Migration

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12 December 2020

SREBP in signal transduction: cholesterol metabolism and beyond

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12 December 2020

Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2

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12 December 2020

AKT/PKB signaling: navigating downstream

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12 December 2020

Genetic heterogeneity of autosomal dominant hypercholesterolemia.

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12 December 2020

A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9.

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The Akt-SREBP nexus: cell signaling meets lipid metabolism.

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12 December 2020

AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth

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12 December 2020

Systematic review on evidence of the effectiveness of cholesterol-lowering drugs

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12 December 2020

Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930

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12 December 2020

Next-generation Akt inhibitors provide greater specificity: effects on glucose metabolism in adipocytes.

1 reference

12 December 2020

Chenodeoxycholic acid stabilization of LDL receptor mRNA depends on 3′-untranslated region and AU-rich element-binding protein

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12 December 2020

Perifosine , an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity

1 reference

12 December 2020

Perifosine as a potential novel anti-cancer agent inhibits EGFR/MET-AKT axis in malignant pleural mesothelioma

1 reference

12 December 2020

Identification and quantification of AKT isoforms and phosphoforms in breast cancer using a novel nanofluidic immunoassay

1 reference

12 December 2020

A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors

1 reference

12 December 2020

Differential transcriptional effects of EGFR inhibitors

1 reference

12 December 2020

Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers

1 reference

12 December 2020

A kinase-independent function of AKT promotes cancer cell survival

1 reference

12 December 2020

Phase 2 study of MK-2206, an allosteric inhibitor of AKT, as second-line therapy for advanced gastric and gastroesophageal junction cancer: A SWOG cooperative group trial (S1005).

1 reference

12 December 2020

IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma

1 reference

12 December 2020

Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092

1 reference

12 December 2020

A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors

1 reference

12 December 2020

AT7867 Inhibits Human Colorectal Cancer Cells via AKT-Dependent and AKT-Independent Mechanisms

1 reference

12 December 2020

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

1 reference

12 December 2020

MK-2206, an allosteric inhibitor of AKT, stimulates LDLR expression and LDL uptake: A potential hypocholesterolemic agent

1 reference

12 December 2020

Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0218537

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31216345%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31216345%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

PubMed publication ID

31216345

1 reference