(Q58846628)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

D M Freymann

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

M A Wenck

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

J C Engel

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

J Feng

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

P J Focia

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

A E Eakin

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

S P Craig

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

language of work or name

English

0 references

publication date

1 December 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

published in

Chemistry and Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

page(s)

957-968

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

A re-examination of purine and pyrimidine synthesis in the three main forms of Trypanosoma cruzi

3 November 2019

cites work

1 reference

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7 January 2021

Purine salvage in Schistosoma mansoni schistosomules

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7 January 2021

Purine salvage enzymes of parasites as targets for structure-based inhibitor design

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7 January 2021

The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP

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7 January 2021

Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus

1 reference

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7 January 2021

Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop

1 reference

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7 January 2021

Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry

1 reference

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7 January 2021

A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi

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7 January 2021

Approaching the transition state in the crystal structure of a phosphoribosyltransferase

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7 January 2021

Flexible ligand docking using conformational ensembles

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7 January 2021

Ligand solvation in molecular docking.

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7 January 2021

Structure-based strategies for drug design and discovery

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7 January 2021

Automated docking with grid-based energy evaluation

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7 January 2021

A geometric approach to macromolecule-ligand interactions

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7 January 2021

Structure-based discovery and in-parallel optimization of novelcompetitive inhibitors of thymidylate synthase

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7 January 2021

Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase

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7 January 2021

Steady-State Kinetics of the Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Tritrichomonas foetus: The Role of Threonine-47

1 reference

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7 January 2021

Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan

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7 January 2021

Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

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7 January 2021

Enzymes of purine salvage in Trypanosoma cruzi

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7 January 2021

Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis

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7 January 2021

Purine metabolism in Trypanosoma cruzi

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7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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7 January 2021

Solvent-accessible surfaces of proteins and nucleic acids

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7 January 2021

Using shape complementarity as an initial screen in designing ligands for a receptor binding site of known three-dimensional structure.

1 reference

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7 January 2021

Matching chemistry and shape in molecular docking

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900045-4

7 January 2021

Molecular docking using shape descriptors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900045-4

7 January 2021

Orientational sampling and rigid-body minimization in molecular docking

1 reference

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7 January 2021

Calculation of electrostatic potentials in an enzyme active site

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7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

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7 January 2021

Detection, delineation, measurement and display of cavities in macromolecular structures

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7 January 2021

End products and enzyme levels of aerobic glucose fermentation in trypanosomatids

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7 January 2021

Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi

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7 January 2021

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor

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7 January 2021

Purine phosphoribosyltransferases.

1 reference

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7 January 2021

10.1016/S1074-5521(00)00045-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11137818%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference