(Q48567301)

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A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.

scientific article published in June 2002

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10 November 2019

A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration (English)

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10 November 2019

neurodegeneration

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12

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10 November 2019

14

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10 November 2019

J. David Sweatt

11

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10 November 2019

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Kei Watase

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10 November 2019

Edwin J Weeber

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10 November 2019

Bisong Xu

3

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10 November 2019

Barbara Antalffy

4

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10 November 2019

Lisa Yuva-Paylor

5

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10 November 2019

Kouichi Hashimoto

6

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10 November 2019

Masanobu Kano

7

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10 November 2019

Richard Atkinson

8

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10 November 2019

Yaling Sun

9

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10 November 2019

Dawna L Armstrong

10

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10 November 2019

Richard Paylor

13

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10 November 2019

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1 June 2002

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10 November 2019

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10 November 2019

34

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10 November 2019

6

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10 November 2019

905-919

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10 November 2019

Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice

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Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

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Clinical, neuropathologic, and genetic studies of a large spinocerebellar ataxia type 1 (SCA1) kindred

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

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Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.

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Repeat instability and motor incoordination in mice with a targeted expanded CAG repeat in the Sca1 locus

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Identifiers

10.1016/S0896-6273(02)00733-X

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PubMed publication ID

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10 November 2019

PubMed publication ID

1 reference

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PubMed publication ID

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10 November 2019

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