(Q48417506)

English

Glucose, Lactate, β-Hydroxybutyrate, Acetate, GABA, and Succinate as Substrates for Synthesis of Glutamate and GABA in the Glutamine-Glutamate/GABA Cycle

scientific article published in January 2016

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27885625

Glucose, Lactate, β-Hydroxybutyrate, Acetate, GABA, and Succinate as Substrates for Synthesis of Glutamate and GABA in the Glutamine-Glutamate/GABA Cycle (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27885625

1

object named as

Leif Hertz

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

author name string

Douglas L Rothman

2

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27885625

publication date

1 January 2016

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27885625

Advances in neurobiology

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27885625

13

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27885625

9-42

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27885625

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Brain Lactate Metabolism: The Discoveries and the Controversies

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Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats

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Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons

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Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria

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Glutamine synthetase protects against neuronal degeneration in injured retinal tissue

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Contribution of astrocytic glutamate and GABA uptake to corticostriatal information processing.

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Brain Metabolism during Fasting*

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[2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain

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Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation.

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Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy

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Distribution of activities of aspartate aminotransferase isoenzymes and malate dehydrogenase in guinea pig retinal layers

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13C MRS studies of neuroenergetics and neurotransmitter cycling in humans

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Characterization of Glutamate Decarboxylase (GAD) from Lactobacillus sakei A156 Isolated from Jeot-gal.

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Intramitochondrial localization of the 4-aminobutyrate-2-oxoglutarate transaminase from ox brain

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Uptake and metabolism of GABA in astrocytes cultured from dissociated mouse brain hemispheres

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Structure, function, and plasticity of GABA transporters

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21 January 2018

15N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain

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21 January 2018

Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity

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21 January 2018

In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during

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Induction of brain D(--)-beta-hydroxybytrate dehydrogenase activity by fasting

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The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.

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21 January 2018

Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources

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21 January 2018

Glutamate synthesis has to be matched by its degradation - where do all the carbons go?

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21 January 2018

The effect of some inorganic ions on brain slices metabolizing glucose or pyruvate

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The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release

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21 January 2018

Blood lactate is an important energy source for the human brain.

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Developmental switch in brain nutrient transporter expression in the rat.

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A multicenter study of the efficacy of the ketogenic diet.

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21 January 2018

Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain

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Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases

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21 January 2018

Metabolic distinction between vesicular and cytosolic GABA in cultured GABAergic neurons using 13C magnetic resonance spectroscopy

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21 January 2018

Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons

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21 January 2018

Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of alpha-ketoglutarate dehydrogenase

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Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine

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Ammonia detoxification by accelerated oxidation of branched chain amino acids in brains of acute hepatic failure rats

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Immunochemical studies of brain glutamate decarboxylase and GABA-transaminase of six inbred strains of mice

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In vivo evidence for lactate as a neuronal energy source

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Pyruvate carboxylase activity in primary cultures of astrocytes and neurons

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Effect of glycerol on gluconeogenesis in isolated rabbit kidney cortex tubules.

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Differential expression of glutamate dehydrogenase in cultured neurons and astrocytes from mouse cerebellum and cerebral cortex

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21 January 2018

The effect of pH and ADP on ammonia affinity for human glutamate dehydrogenases.

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

21 January 2018

Metabolism of succinic acid methyl esters in neural cells.

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

21 January 2018

Ketosis proportionately spares glucose utilization in brain.

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

21 January 2018

Roles of changes in active glutamine transport in brain edema development during hepatic encephalopathy: an emerging concept

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

21 January 2018

Analysis of glutamine accumulation in rat brain mitochondria in the presence of a glutamine uptake inhibitor, histidine, reveals glutamine pools with a distinct access to deamidation

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

21 January 2018

Glutamine synthetase as an astrocytic marker: its cell type and vesicle localization

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Dynamic measurements of cerebral pentose phosphate pathway activity in vivo using [1,6-13C2,6,6-2H2]glucose and microdialysis.

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

GABA and Glutamate Uptake and Metabolism in Retinal Glial (Müller) Cells

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Quantitative analysis of neurotransmitter pathways under steady state conditions - a perspective

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Metabolism of glucose into glutamate via the hexose monophosphate shunt and its inhibition by 6-aminonicotinamide in rat brain in vivo

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

A mathematical model of compartmentalized neurotransmitter metabolism in the human brain

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

The Glutamate-Glutamine (GABA) Cycle: Importance of Late Postnatal Development and Potential Reciprocal Interactions between Biosynthesis and Degradation

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Role of Branched‐Chain Aminotransferase Isoenzymes and Gabapentin in Neurotransmitter Metabolism

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Function of leucine in excitatory neurotransmitter metabolism in the central nervous system

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Differences in uptake kinetics of cis-3-aminocyclohexane carboxylic acid into neurons and astrocytes in primary cultures

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Evidence that aspartate aminotransferase activity and ketodicarboxylate carrier function are essential for biosynthesis of transmitter glutamate

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for release of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Anion transport in rat brain mitochondria: Fumarate uptake via the dicarboxylate carrier

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Physiological roles of ketone bodies as substrates and signals in mammalian tissues

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

GABA release provoked by disturbed Na(+), K(+) and Ca(2+) homeostasis in cerebellar nerve endings: roles of Ca(2+) channels, Na(+)/Ca(2+) exchangers and GAT1 transporter reversal

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA.

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Transport of glutamate and other amino acids at the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

NMR spectroscopic studies of 13C acetate and 13C glucose metabolism in neocortical astrocytes: evidence for mitochondrial heterogeneity

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Astrocyte glucose metabolism under normal and pathological conditions in vitro

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Lactate-mediated glia-neuronal signalling in the mammalian brain

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Effect of Acetate on Hypoglycemic Seizures in Mice

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

The regeneration of reduced glutathione in rat forebrain mitochondria identifies metabolic pathways providing the NADPH required

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Preferential Utilization of Acetate by Astrocytes Is Attributable to Transport

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Evaluation of the importance of transamination versus deamination in astrocytic metabolism of [U-13C]glutamate

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Alterations in Uptake and Release Rates for GABA, Glutamate, and Glutamine During Biochemical Maturation of Highly Purified Cultures of Cerebral Cortical Neurons, a GABAergic Preparation

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Astrocyte leucine metabolism: significance of branched-chain amino acid transamination

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

GABA and Glutamate Transporters in Brain

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-45096-4_2

31 March 2020

Identifiers

10.1007/978-3-319-45096-4_2

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27885625

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