(Q48182042)

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The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

Sidney Strickland

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

author name string

Jerry P Melchor

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Robert Pawlak

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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publication date

1 October 2003

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Europe PubMed Central

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19 December 2019

Journal of Neuroscience

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

23

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

26

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

8867-8871

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The plasmin system is induced by and degrades amyloid-beta aggregates

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue plasminogen activator requires plasminogen to modulate amyloid-beta neurotoxicity and deposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearing the brain's amyloid cobwebs

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ham-Wasserman lecture: role of the plasminogen system in fibrin-homeostasis and tissue remodeling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue plasminogen activator and seizures: a clot-buster's secret life

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of Type 1 Plasminogen Activator Inhibitor and Vitronectin at Sites of Cellular Necrosis and Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet protease nexin-2/amyloid beta-protein precursor. Possible pathologic and physiologic functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amiloride selectively inhibits the urokinase-type plasminogen activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid β-peptide analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasminogen activator inhibitor-1 in the cerebrospinal fluid as an index of neurological disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular proteolysis in the adult murine brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal cell death and tPA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid β-Protein (Aβ) 1–40 But Not Aβ1–42 Contributes to the Experimental Formation of Alzheimer Disease Amyloid Fibrils in Rat Brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.23-26-08867.2003

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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