(Q47589437)

4 February 2018

http://europepmc.org/abstract/MED/26888927

title

Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives (English)

1 reference

4 February 2018

http://europepmc.org/abstract/MED/26888927

author

Vojtech Vyklicky

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Martin Horak

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Lenka Kletečková

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Jiri Cerny

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Michaela Nekardová

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

author name string

Tereza Smejkalova

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Barbora Krausova

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Ales Balik

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Miloslav Korinek

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Jirina Borovska

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Karel Vales

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Hana Chodounska

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Eva Kudova

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Marketa Chvojkova

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

Ladislav Vyklicky

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

language of work or name

English

0 references

publication date

1 February 2016

1 reference

4 February 2018

http://europepmc.org/abstract/MED/26888927

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

volume

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

page(s)

2161-2175

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines

15 May 2020

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Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating

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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

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Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors.

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The time course of glutamate in the synaptic cleft

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Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats

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Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

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The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease

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The neuroactive steroid 3-alpha-ol-5-beta-pregnan-20-one hemisuccinate, a selective NMDA receptor antagonist improves behavioral performance following spinal cord ischemia

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Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors.

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20-oxo-5beta-pregnan-3alpha-yl sulfate is a use-dependent NMDA receptor inhibitor.

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12 December 2020

3alpha-OL-5-beta-pregnan-20-one hemisuccinate, a steroidal low-affinity NMDA receptor antagonist improves clinical rating scores in a rabbit multiple infarct ischemia model: synergism with tissue plasminogen activator

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12 December 2020

Thermodynamic penalty arising from burial of a ligand polar group within a hydrophobic pocket of a protein receptor.

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12 December 2020

Density functional theory augmented with an empirical dispersion term. Interaction energies and geometries of 80 noncovalent complexes compared with ab initio quantum mechanics calculations

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12 December 2020

Extracellular glutamate concentration in hippocampal slice

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12 December 2020

A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats

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12 December 2020

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

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12 December 2020

The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism

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12 December 2020

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

1 reference

12 December 2020

Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons.

1 reference

12 December 2020

Pregnanolone sulfate promotes desensitization of activated NMDA receptors.

1 reference

12 December 2020

The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death

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12 December 2020

Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury

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12 December 2020

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

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12 December 2020

A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu

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12 December 2020

The effect of an N-methyl-D-aspartate lesion in the hippocampus on glial and neuronal marker proteins

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12 December 2020

A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonists

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12 December 2020

Glutamate receptor ion channels: structure, regulation, and function

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12 December 2020

Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses

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12 December 2020

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

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12 December 2020

Pregnenolone sulfate increases glutamate release at neonatal climbing fiber-to-Purkinje cell synapses

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12 December 2020

Animal Models of Schizophrenia

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12 December 2020

Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate.

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Excitatory amino acid antagonists and memory: effect of drugs acting at N-methyl-D-aspartate receptors in learning and memory tasks

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Access of inhibitory neurosteroids to the NMDA receptor

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12 December 2020

Systemic administration of MK-801 protects against N-methyl-D-aspartate- and quisqualate-mediated neurotoxicity in perinatal rats

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12 December 2020

Synaptic NMDA receptors mediate hypoxic excitotoxic death

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12 December 2020

Distribution of extrasynaptic NMDA receptors on neurons

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12 December 2020

Analysis of neurotransmitter release mechanisms by photolysis of caged Ca²⁺ in an autaptic neuron culture system

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12 December 2020

Leading compounds for the validation of animal models of psychopathology

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12 December 2020

Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine

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12 December 2020

AMPARs and synaptic plasticity: the last 25 years

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12 December 2020

Structure, function, and pharmacology of NMDA receptor channels

1 reference

12 December 2020

Consequences of early postnatal benzodiazepines exposure in rats. I. Cognitive-like behavior.

1 reference

12 December 2020

Extrasynaptic NMDA receptor involvement in central nervous system disorders

1 reference

12 December 2020

Crystal structure of a heterotetrameric NMDA receptor ion channel

1 reference

12 December 2020

NMDA receptor structures reveal subunit arrangement and pore architecture

1 reference

12 December 2020

Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons.

1 reference

12 December 2020

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule

1 reference

12 December 2020

A New Class of Potent N-Methyl-D-Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D-Ring Modifications.

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12 December 2020

Ionic dependence of glutamate neurotoxicity

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12 December 2020

Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

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12 December 2020

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

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12 December 2020

Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide

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12 December 2020

Extracellular glutamate during focal cerebral ischaemia in rats: time course and calcium dependency

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12 December 2020

Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

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12 December 2020

Comparative protein modelling by satisfaction of spatial restraints

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12 December 2020

Trapping channel block of NMDA-activated responses by amantadine and memantine

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12 December 2020

Neuroprotective activity of a new class of steroidal inhibitors of the N -methyl- d -aspartate receptor

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12 December 2020

10.1523/JNEUROSCI.3181-15.2016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

release_7dognytrlbhxzo5kxr2m2cgg3y

15 May 2020

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Fatcat

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24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6602038&resulttype=core&format=json

15 May 2020

1 reference