(Q46661944)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

title

Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

author name string

S Finkin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Y Aylon

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

S Anzi

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

E Shaulian

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

language of work or name

English

0 references

publication date

7 April 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

volume

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

issue

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

page(s)

4411-4421

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18391985%20AND%20SRC:MED&resulttype=core&format=json

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

5 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Cyclin E restores p53 activity in contact-inhibited cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Centrosome control of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Cyclin E dysregulation and chromosomal instability in endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Aurora-A - a guardian of poles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Mechanisms of tumor suppression by the SCF(Fbw7).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Ras activity regulates cyclin E degradation by the Fbw7 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

The Drosophila F box protein archipelago regulates dMyc protein levels in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Skp2-mediated degradation of p27 regulates progression into mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Inactivation of hCDC4 can cause chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Cyclin E-CDK2 is a regulator of p27Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Deregulated cyclin E induces chromosome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.77