(Q46368609)

21 December 2017

title

Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes (English)

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21 December 2017

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Hideaki Kaneto

1

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21 December 2017

Taka-Aki Matsuoka

2

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21 December 2017

Yoshihisa Nakatani

3

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21 December 2017

Dan Kawamori

4

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21 December 2017

Takeshi Miyatsuka

5

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21 December 2017

Munehide Matsuhisa

6

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21 December 2017

Yoshimitsu Yamasaki

7

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21 December 2017

publication date

10 March 2005

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21 December 2017

Journal of Molecular Medicine

published in

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21 December 2017

volume

83

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21 December 2017

issue

6

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21 December 2017

page(s)

429-439

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21 December 2017

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

cites work

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12 December 2020

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

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12 December 2020

Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

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12 December 2020

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

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12 December 2020

Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development. A potential role of PDX-1 in transcriptional activation.

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12 December 2020

Experimental control of pancreatic development and maintenance

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12 December 2020

Modulation of the JNK pathway in liver affects insulin resistance status

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12 December 2020

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

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12 December 2020

Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

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12 December 2020

In vitro cultivation of human islets from expanded ductal tissue

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12 December 2020

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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12 December 2020

Cytokines suppress human islet function irrespective of their effects on nitric oxide generation

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12 December 2020

Beta-cell adaptation and decompensation during the progression of diabetes.

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12 December 2020

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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12 December 2020

Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells

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12 December 2020

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide

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12 December 2020

Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes

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12 December 2020

Translational control in the endoplasmic reticulum stress response

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12 December 2020

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

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12 December 2020

Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin

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12 December 2020

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

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12 December 2020

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12 December 2020

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection

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12 December 2020

Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress

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12 December 2020

Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

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12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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12 December 2020

beta-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas.

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12 December 2020

beta-cell apoptosis: stimuli and signaling

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12 December 2020

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

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12 December 2020

Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells

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12 December 2020

Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction

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12 December 2020

A central role for JNK in obesity and insulin resistance

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12 December 2020

IB1 reduces cytokine-induced apoptosis of insulin-secreting cells

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12 December 2020

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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12 December 2020

A new cell-permeable peptide allows successful allogeneic islet transplantation in mice

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12 December 2020

Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells

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12 December 2020

PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells.

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12 December 2020

The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells

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12 December 2020

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

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12 December 2020

Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis.

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12 December 2020

PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells

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12 December 2020

Biochemistry and molecular cell biology of diabetic complications

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12 December 2020

The beta cell transcription factors and development of the pancreas

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12 December 2020

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.

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12 December 2020

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

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12 December 2020

Mammalian MAP kinase signalling cascades

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12 December 2020

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

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12 December 2020

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

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12 December 2020

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

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12 December 2020

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

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12 December 2020

In vivo protein transduction: delivery of a biologically active protein into the mouse

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12 December 2020

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

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12 December 2020

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

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12 December 2020

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

1 reference

12 December 2020

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

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12 December 2020

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

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12 December 2020

IPF1, a homeodomain-containing transactivator of the insulin gene

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12 December 2020

Regulatory factor linked to late-onset diabetes?

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12 December 2020

Insulin signalling and the regulation of glucose and lipid metabolism

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12 December 2020

Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain

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12 December 2020

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells

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12 December 2020

Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells

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12 December 2020

Intercellular trafficking and protein delivery by a herpesvirus structural protein

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12 December 2020

Integration of endoplasmic reticulum signaling in health and disease

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12 December 2020

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

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12 December 2020

In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow

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12 December 2020

Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells

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12 December 2020

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

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12 December 2020

Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.

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12 December 2020

ORP150 protects against hypoxia/ischemia-induced neuronal death

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12 December 2020

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

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12 December 2020

Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction

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12 December 2020

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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12 December 2020

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

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12 December 2020

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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12 December 2020

Signal transduction by the JNK group of MAP kinases

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12 December 2020

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression

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12 December 2020

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

1 reference

12 December 2020

Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes

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12 December 2020

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

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12 December 2020

Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter.

1 reference

12 December 2020

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

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12 December 2020

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

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12 December 2020

When translation meets metabolism: multiple links to diabetes

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12 December 2020

Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.

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12 December 2020

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

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12 December 2020

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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12 December 2020

Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15

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12 December 2020

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

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12 December 2020

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene

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12 December 2020

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

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12 December 2020

Cellular uptake of the tat protein from human immunodeficiency virus

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12 December 2020

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression

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12 December 2020

Endoplasmic reticulum stress and the development of diabetes: a review

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12 December 2020

Oxidative damage to DNA in diabetes mellitus

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12 December 2020

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

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12 December 2020

Insulin-promoter-factor 1 is required for pancreas development in mice

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12 December 2020

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

1 reference

12 December 2020

Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

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12 December 2020

Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes.

1 reference

12 December 2020

Functional, persistent, and extended liver to pancreas transdifferentiation.

1 reference

12 December 2020

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

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12 December 2020

Cellular mechanisms of insulin resistance

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12 December 2020

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

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12 December 2020

10.1007/S00109-005-0640-X

Identifiers

DOI

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21 December 2017

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21 December 2017